{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:25:04Z","timestamp":1782217504995,"version":"3.54.5"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The treatment of postburn hypopigmentation was primarily surgical before the advent of new technologies. Medical devices and therapies are emerging to manage scar sequelae that can be disfiguring and associated with severe psychosocial impact. These innovations have been poorly investigated for hypopigmentation, but they represent a real hope. We reviewed all articles published on Pubmed up to June 2022. Included studies had to specifically focus on treating postburn hypopigmented scars. All articles evaluating transient solutions such as make-up, and articles describing inflammation-linked hypopigmentation with no etiological details or no burn injury history were excluded. Through this review, we have highlighted 6 different types of nonsurgical treatments reported in postburn leukoderma potentially allowing definitive results. Electrophoto-biomodulation or E light (combining intensive pulsed light, radiofrequency, and cooling), topical daylight psoralen UVA therapy, and lasers (fractional lasers using pulse energies or CO2FL devices, lasers-assisted drug delivery as local bimatoprost and tretinoin or pimecrolimus) have been explored with encouraging results in hypopigmented burns. Finally, other promising medical strategies include using FK506, a nonsteroidal anti-inflammatory drug, to induce melanogenesis or using melanocyte-stimulating hormones with fractional laser-assisted drug deliveries, which are expected to emerge soon.<\/jats:p>","DOI":"10.1093\/jbcr\/irae030","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T14:24:55Z","timestamp":1708698295000},"page":"601-607","source":"Crossref","is-referenced-by-count":7,"title":["Nonsurgical Treatment of Postburn Hypopigmentation: A Literature Review"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-0861","authenticated-orcid":false,"given":"Elise","family":"Lupon","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Institut Universitaire Locomoteur et du Sport, Pasteur 2 Hospital, University C\u00f4te d\u2019Azur , 06001 Nice , France"},{"name":"Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School , 02114 Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-5132","authenticated-orcid":false,"given":"Yanis","family":"Berkane","sequence":"additional","affiliation":[{"name":"Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School , 02114 Boston, MA , USA"},{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1 , 35000 Rennes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bertheuil","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1 , 35000 Rennes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis L","family":"Cetrulo","sequence":"additional","affiliation":[{"name":"Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School , 02114 Boston, MA , USA"},{"name":"Department of Plastic Surgery, Massachusetts General Hospital , 02114 Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Vaillant","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1 , 35000 Rennes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Chaput","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University Toulouse III Paul Sabatier , 31000 Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Camuzard","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Institut Universitaire Locomoteur et du Sport, Pasteur 2 Hospital, University C\u00f4te d\u2019Azur , 06001 Nice , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre G","family":"Lellouch","sequence":"additional","affiliation":[{"name":"Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School , 02114 Boston, MA , USA"},{"name":"Department of Plastic Surgery, Massachusetts General Hospital , 02114 Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"issue":"4","key":"2024050616493830700_CIT0001","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.burns.2019.10.003","article-title":"Hypopigmentation in burns is associated with alterations in the architecture of the skin and the dendricity of the 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