{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:21:25Z","timestamp":1791415285641,"version":"4.3.3"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Institute for Translational Sciences at the University of Texas Medical Branch"},{"name":"Clinical and Translational Science Award","award":["UL1 TR001439"],"award-info":[{"award-number":["UL1 TR001439"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Severely burned patients often develop cardiac dysfunction and heart failure. The purpose of this retrospective study is to evaluate the role of cardiac troponin I (cTI) and its association to patients with burns. Patients deidentified data were collected from a national database in May 2023. Adult patients with burns who had cTnI lab counted were enrolled in this study. Patients were grouped by the cTnI mean level within 72 h including patients with elevated cTnI levels at &amp;gt;0.3 ng\/mL (n = 2188 patients) and patients with nonelevated cTnI level (&amp;lt;0.04 ng\/mL) (n = 3200). The cohorts were further stratified by less than 20% TBSA mild burn population and &amp;gt;20% TBSA severe burn population to replicate the severity of burns. The 30-day incidences of acute myocardial infarction (MI), sepsis, and mortality were investigated after the cohorts were propensity-matching balanced. The odds ratios (ORs) with 95% CI for MI were (9.829\/7.081-13.645), sepsis (1.527\/1.269-1.959), and mortality (2.586\/2.110-3.170), respectively (P &amp;lt; .05). The groups that were further stratified into mild burn and severe burn had the following results: The mild burn ORs and 95% CI for MI was (6.237\/3.986-9.785), sepsis (1.603\/1.132-2.270), and mortality was (2.298\/1.629-3.242). The severe burn cohort had ORs and 95% CI for MI (3.145\/1.469-6.732), sepsis (0.993\/0.555-1.777), and mortality (2.934\/1.924-4.475). In conclusion, the patients with earlier elevated cTnI levels had worse outcomes of MI and mortality in both severe and mild burns.<\/jats:p>","DOI":"10.1093\/jbcr\/irae086","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T08:38:39Z","timestamp":1716453519000},"page":"1139-1147","source":"Crossref","is-referenced-by-count":5,"title":["Elevated Cardiac Troponin I Level Associated to Cardiac Dysfunction in Burned Patients"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7276-6819","authenticated-orcid":false,"given":"Carolina","family":"Segura","sequence":"first","affiliation":[{"name":"University of Texas Medical Branch Department of Surgery, , 301 University Boulevard , Galveston, TX 77555-0644, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-2767","authenticated-orcid":false,"given":"George","family":"Golovko","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch Department of Obstetrics and Gynecology, , 301 University Boulevard , Galveston, TX 77555-0644, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9442-2252","authenticated-orcid":false,"given":"Isabel","family":"Obias","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch Department of Surgery, , 301 University Boulevard , Galveston, TX 77555-0644, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9386-5395","authenticated-orcid":false,"given":"Suhaib","family":"Shah","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch Department of Surgery, , 301 University Boulevard , Galveston, TX 77555-0644, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-0633","authenticated-orcid":false,"given":"Amina","family":"El Ayadi","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch Department of Pharmacology, , 301 University Boulevard , Galveston, TX 77555-0644, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-3440","authenticated-orcid":false,"given":"Steven","family":"Wolf","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch Department of Pharmacology, , 301 University Boulevard , Galveston, TX 77555-0644, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-9078","authenticated-orcid":false,"given":"Juquan","family":"Song","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch Department of Pharmacology, , 301 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Burn Care Res."},{"issue":"5\u20136","key":"2024090619130717300_CIT0004","first-page":"269","article-title":"The cardiovascular response to burn injury","volume":"195","author":"Hayes","year":"2008","journal-title":"Curr Anaesth Crit Care"},{"issue":"12","key":"2024090619130717300_CIT0005","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.hlc.2021.06.444","article-title":"Burn-induced cardiac dysfunction: a brief review and long-term consequences for cardiologists in clinical practice","volume":"30","author":"Krbcova Moudra","year":"2021","journal-title":"Heart Lung Circul"},{"key":"2024090619130717300_CIT0006","doi-asserted-by":"crossref","first-page":"tkaa049","DOI":"10.1093\/burnst\/tkaa049","article-title":"A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns","volume":"9","author":"Carlton","year":"2021","journal-title":"Burns 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