{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:48:17Z","timestamp":1761677297230,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM092804"],"award-info":[{"award-number":["GM092804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shriners Hospitals for Children-Boston","award":["85110-BOS-22"],"award-info":[{"award-number":["85110-BOS-22"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The recovery of patients after severe burns is a long and complex process. Genomic analysis of white blood cells from burn and trauma patients revealed excessive and prolonged innate immune activation in patients with complicated outcomes. However, translating this knowledge into practical biomarkers has not been possible yet. Although several biomarkers for monitoring burn patients have been proposed, their ability to accurately distinguish between inflammation stemming from initial tissue destruction, infections, and organ failure complications is limited. Here, we focused on monocytes, critical innate immune cells in the response to burn injured tissues. We measured the monocyte anisocytosis (quantified as monocyte distribution width (MDW), a recently emerged marker of sepsis) throughout the recovery of patients from the time of burn injury until the end of the hospital stay. We observed that MDW increases in patients during the first week after major burns. Among the patients with major burns who survive, MDW starts decreasing in the second week and normalizes by the end of the hospital stay. The duration of hospital stay appears to be proportional to how fast MDW decreases during the second week after the injury. We also found that MDW decreases significantly in most patients after excision and debridement surgeries but not after allo- and auto-graft surgeries. Moreover, high MDW values correlated with a higher rate of positive microbiology blood culture samples and respiratory infections. These findings underscore the importance of monitoring MDW as a potential biomarker for the risk of complications during burn patient recovery.<\/jats:p>","DOI":"10.1093\/jbcr\/irae088","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T07:39:16Z","timestamp":1716536356000},"page":"138-144","source":"Crossref","is-referenced-by-count":2,"title":["Monocyte Anisocytosis Changes in Patients After Major Burn Injuries"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-7141","authenticated-orcid":false,"given":"Saeed","family":"Nazemidashtarjandi","sequence":"first","affiliation":[{"name":"Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital , Boston, MA 02129 ,","place":["USA"]},{"name":"Harvard Medical School , Boston, MA 02114,","place":["USA"]},{"name":"Shriners Children\u2019s Boston , Boston, MA 02114 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3258-9086","authenticated-orcid":false,"given":"Sinan","family":"Muldur","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital , Boston, MA 02129 ,","place":["USA"]},{"name":"Harvard Medical School , Boston, MA 02114,","place":["USA"]},{"name":"Shriners Children\u2019s Boston , Boston, MA 02114 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D","family":"Supple","sequence":"additional","affiliation":[{"name":"Sumner Redstone Burn Center, Massachusetts General Hospital Department of Surgery, , Boston, MA 02114,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-936X","authenticated-orcid":false,"given":"Colleen M","family":"Ryan","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA 02114,","place":["USA"]},{"name":"Shriners Children\u2019s Boston , Boston, MA 02114 ,","place":["USA"]},{"name":"Sumner Redstone Burn Center, Massachusetts General Hospital Department of Surgery, , Boston, MA 02114,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1711-8227","authenticated-orcid":false,"given":"Lael M","family":"Yonker","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA 02114,","place":["USA"]},{"name":"Mucosal Immunology and Biology Research Center, Massachusetts General Hospital Department of Pediatrics, , Boston, MA 02114,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-5593","authenticated-orcid":false,"given":"Murat N","family":"Karabacak","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital , Boston, MA 02129 ,","place":["USA"]},{"name":"Harvard Medical School , Boston, MA 02114,","place":["USA"]},{"name":"Shriners Children\u2019s Boston , Boston, MA 02114 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Goverman","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA 02114,","place":["USA"]},{"name":"Shriners Children\u2019s Boston , Boston, MA 02114 ,","place":["USA"]},{"name":"Sumner Redstone Burn Center, Massachusetts General Hospital Department of Surgery, , Boston, MA 02114,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin L","family":"Yarmush","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital , Boston, MA 02129 ,","place":["USA"]},{"name":"Harvard Medical School , Boston, MA 02114,","place":["USA"]},{"name":"Shriners Children\u2019s Boston , Boston, MA 02114 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-2082","authenticated-orcid":false,"given":"Daniel","family":"Irimia","sequence":"additional","affiliation":[{"name":"Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital , Boston, MA 02129 ,","place":["USA"]},{"name":"Harvard Medical School , Boston, MA 02114,","place":["USA"]},{"name":"Shriners Children\u2019s Boston , Boston, MA 02114 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"issue":"5","key":"2025012508570017500_CIT0001","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/jbcr\/irad105","article-title":"Invasive non-candida fungal infections in acute burns\u2014a 13-year review of a single institution and review of the literature","volume":"44","author":"Akhavan","year":"2023","journal-title":"J Burn Care Res"},{"issue":"3","key":"2025012508570017500_CIT0002","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.suc.2023.01.005","article-title":"Critical care of the burn patient","volume":"103","author":"Britton","year":"2023","journal-title":"Surg Clin North Am"},{"issue":"10","key":"2025012508570017500_CIT0003","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1097\/00003246-200910000-00021","article-title":"Critical care of the burn patient: the first 48 hours","volume":"37","author":"Latenser","year":"2009","journal-title":"Crit Care Med"},{"issue":"3","key":"2025012508570017500_CIT0004","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/2321-3868.123071","article-title":"Burn care: the challenges of research","volume":"1","author":"Wood","year":"2013","journal-title":"Burns 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