{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:52:08Z","timestamp":1792515128767,"version":"4.5.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K08GM124499"],"award-info":[{"award-number":["K08GM124499"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM151165"],"award-info":[{"award-number":["R35GM151165"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pediatric burn injuries are a leading cause of morbidity with infections being the most common acute complication. Thermal injuries elicit a heightened cytokine response while suppressing immune function; however, the mechanisms leading to this dysfunction are still unknown. Our aim was to identify extracellular proteins and circulating phosphoprotein expression in the plasma after burn injury to predict the development of nosocomial infection (NI). Plasma was collected within 72 hours after injury from 64 pediatric burn subjects; of these, 18 went on to develop an NI. Extracellular damage-associated molecular proteins, FAS(APO), and protein kinase b (AKT) signaling phosphoproteins were analyzed. Subjects who went on to develop an NI had elevated high-mobility group box 1, heat shock protein 90 (HSP90), and FAS expression than those who did not develop an NI after injury (NoNI). Concurrently, phosphorylated (p-)AKT and mammalian target of rapamycin (p-mTOR) were elevated in those subjects who went on to develop an NI. Quadratic discriminant analysis revealed distinct differential profiles between NI and NoNI burn subjects using HSP90, FAS, and p-mTOR. The area under the receiver-operator characteristic curves displayed significant ability to distinguish between these 2 burn subject cohorts. These findings provide insight into predicting the signaling proteins involved in the development of NI in pediatric burn patients. Further, these proteins show promise as a diagnostic tool for pediatric burn patients at risk of developing infection while additional investigation may lead to potential therapeutics to prevent NI.<\/jats:p>","DOI":"10.1093\/jbcr\/irae111","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T06:06:35Z","timestamp":1718172395000},"page":"1607-1616","source":"Crossref","is-referenced-by-count":3,"title":["FAS(APO), DAMP, and AKT Phosphoproteins Expression Predict the Development of Nosocomial Infection After Pediatric Burn Injury"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6759-9861","authenticated-orcid":false,"given":"Julia","family":"Penatzer","sequence":"first","affiliation":[{"name":"Center for Clinical and Translation Research, The Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH 43205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6584-6419","authenticated-orcid":false,"given":"Lisa","family":"Steele","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Nationwide Children\u2019s Hospital , Columbus, OH 43205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Breuer","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Nationwide Children\u2019s Hospital , Columbus, OH 43205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5399-5310","authenticated-orcid":false,"given":"Renata","family":"Fabia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Burn Center, Nationwide Children\u2019s Hospital , Columbus, OH 43205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hall","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translation Research, The Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH 43205 ,","place":["USA"]},{"name":"Division of Critical Care Medicine, Nationwide Children\u2019s Hospital , Columbus, OH 43205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2553-8574","authenticated-orcid":false,"given":"Rajan K","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translation Research, The Research Institute at Nationwide Children\u2019s Hospital , Columbus, OH 43205 ,","place":["USA"]},{"name":"Department of Pediatric Surgery, Burn Center, Nationwide Children\u2019s Hospital , Columbus, OH 43205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"2024111510195426800_CIT0001","author":"American Burn Association","year":"2017"},{"issue":"1","key":"2024111510195426800_CIT0002","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1053\/j.sempedsurg.2014.11.008","article-title":"Overview of current pediatric burn care","volume":"24","author":"Gonzalez","year":"2015","journal-title":"Semin Pediatr Surg"},{"key":"2024111510195426800_CIT0003","author":"World Health Organization","year":"2018"},{"issue":"3","key":"2024111510195426800_CIT0004","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/jbcr\/iraa193","article-title":"Measures of systemic innate immune function predict the risk of nosocomial infection in pediatric burn patients","volume":"42","author":"Thakkar","year":"2020","journal-title":"J Burn Care Res"},{"issue":"1","key":"2024111510195426800_CIT0005","first-page":"6","article-title":"The systemic immune response to pediatric thermal injury","volume":"8","author":"Devine","year":"2018","journal-title":"Int J Burns Trauma"},{"issue":"8","key":"2024111510195426800_CIT0006","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.3390\/jcm11082262","article-title":"The role of the immune system in pediatric burns: a systematic review","volume":"11","author":"Korzeniowski","year":"2022","journal-title":"J Clin Med"},{"issue":"2","key":"2024111510195426800_CIT0007","first-page":"89","article-title":"A study on biomarkers, cytokines, and growth factors in children with burn injuries","volume":"20","author":"Abdel-Hafez","year":"2007","journal-title":"Ann Burns Fire Disasters"},{"issue":"1","key":"2024111510195426800_CIT0008","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/01.shk.0000235138.20775.36","article-title":"Serum cytokine differences in severely burned children with and without sepsis","volume":"27","author":"Finnerty","year":"2007","journal-title":"Shock"},{"issue":"1","key":"2024111510195426800_CIT0009","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/01.shk.0000223120.26394.7d","article-title":"Cytokine expression profile over time in severely burned pediatric patients","volume":"26","author":"Finnerty","year":"2006","journal-title":"Shock"},{"issue":"19","key":"2024111510195426800_CIT0010","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.3390\/cells11193073","article-title":"The immune and regenerative response to burn injury","volume":"11","author":"Burgess","year":"2022","journal-title":"Cells"},{"issue":"9\u201310","key":"2024111510195426800_CIT0011","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2119\/2007-00132.Finnerty","article-title":"Temporal cytokine profiles in severely burned patients: a comparison of adults and children","volume":"14","author":"Finnerty","year":"2008","journal-title":"Mol Med"},{"issue":"6","key":"2024111510195426800_CIT0012","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1093\/jbcr\/irac050","article-title":"Measures of adaptive immune function predict the risk of nosocomial infection in pediatric burn patients","volume":"43","author":"Thakkar","year":"2022","journal-title":"J Burn Care Res"},{"issue":"940835","key":"2024111510195426800_CIT0013","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2022.940835","article-title":"Early detection of soluble CD27, BTLA, and TIM-3 predicts the development of nosocomial infection in pediatric burn patients","volume":"13","author":"Penatzer","year":"2022","journal-title":"Front Immunol"},{"issue":"2","key":"2024111510195426800_CIT0014","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/SHK.0000000000002253","article-title":"Altered profiles of extracellular mitochondrial DNA in immunoparalyzed pediatric patients after thermal injury","volume":"61","author":"Tetri","year":"2023","journal-title":"Shock"},{"issue":"4","key":"2024111510195426800_CIT0015","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"2024111510195426800_CIT0016","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jss.2021.01.012","article-title":"Circulating sFasL levels predict the severity and outcome of burn injury: a prospective observational study","volume":"265","author":"Lin","year":"2021","journal-title":"J Surg Res"},{"issue":"4","key":"2024111510195426800_CIT0017","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-associated molecular patterns in inflammatory diseases","volume":"18","author":"Roh","year":"2018","journal-title":"Immune Netw"},{"issue":"10","key":"2024111510195426800_CIT0018","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1089\/ars.2017.7069","article-title":"Lysophospholipids and their receptors serve as conditional DAMPs and DAMP receptors in tissue oxidative and inflammatory injury","volume":"28","author":"Shao","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"2024111510195426800_CIT0019","doi-asserted-by":"crossref","DOI":"10.1002\/9781119060208","volume-title":"Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation","author":"Boyd","year":"2019"},{"key":"2024111510195426800_CIT0020","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cyto.2015.12.006","article-title":"Spatiotemporal phosphoprotein distribution and associated cytokine response of a traumatic injury","volume":"79","author":"Han","year":"2016","journal-title":"Cytokine"},{"issue":"7","key":"2024111510195426800_CIT0021","doi-asserted-by":"publisher","first-page":"e07552","DOI":"10.1016\/j.heliyon.2021.e07552","article-title":"Differential phosphoprotein signaling in the cortex in mouse models of Gulf War illness using corticosterone and acetylcholinesterase inhibitors","volume":"7","author":"Penatzer","year":"2021","journal-title":"Heliyon"},{"issue":"2","key":"2024111510195426800_CIT0022","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3892\/ijmm.2017.3036","article-title":"The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy","volume":"40","author":"Ardito","year":"2017","journal-title":"Int J Mol Med"},{"issue":"32","key":"2024111510195426800_CIT0023","doi-asserted-by":"publisher","first-page":"11732","DOI":"10.1073\/pnas.1400520111","article-title":"Spatiotemporal control of epithelial remodeling by regulated myosin phosphorylation","volume":"111","author":"Kasza","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2024111510195426800_CIT0024","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s004410000197","article-title":"Tyrosine phosphorylation: a critical component in the formation of hemidesmosomes","volume":"300","author":"Payne","year":"2000","journal-title":"Cell Tissue Res"},{"issue":"1","key":"2024111510195426800_CIT0025","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tibs.2004.11.009","article-title":"Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation","volume":"30","author":"Viatour","year":"2005","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"2024111510195426800_CIT0026","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0092-8674(95)90405-0","article-title":"Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling","volume":"80","author":"Hunter","year":"1995","journal-title":"Cell"},{"issue":"19","key":"2024111510195426800_CIT0027","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.1046\/j.0014-2956.2001.02473.x","article-title":"The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture","volume":"268","author":"Cohen","year":"2001","journal-title":"Eur J Biochem"},{"issue":"8","key":"2024111510195426800_CIT0028","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.3390\/molecules22081287","article-title":"Recent advances in the inhibition of p38 MAPK as a potential strategy for the treatment of Alzheimer\u2019s disease","volume":"22","author":"Lee","year":"2017","journal-title":"Molecules"},{"issue":"5\u20136","key":"2024111510195426800_CIT0029","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3109\/08830189809054411","article-title":"Tyrosine phosphorylated proteins in synovial cells of rheumatoid arthritis","volume":"17","author":"Takeuchi","year":"1998","journal-title":"Int Rev Immunol"},{"issue":"5","key":"2024111510195426800_CIT0030","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","author":"Horan","year":"2008","journal-title":"Am J Infect Control"},{"issue":"2","key":"2024111510195426800_CIT0031","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.jss.2010.05.035","article-title":"Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline","volume":"171","author":"Schaeffer","year":"2011","journal-title":"J Surg Res"},{"issue":"3","key":"2024111510195426800_CIT0032","doi-asserted-by":"publisher","first-page":"128","DOI":"10.4103\/2229-5151.100889","article-title":"Pediatric burn injuries","volume":"2","author":"Krishnamoorthy","year":"2012","journal-title":"Int J Crit Illn Inj Sci"},{"issue":"2","key":"2024111510195426800_CIT0033","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/SHK.0000000000002037","article-title":"Demographics to define pediatric burn patients at risk of adverse outcomes","volume":"59","author":"Penatzer","year":"2023","journal-title":"Shock"},{"issue":"6","key":"2024111510195426800_CIT0034","doi-asserted-by":"publisher","first-page":"R183","DOI":"10.1186\/cc8170","article-title":"The leading causes of death after burn injury in a single pediatric burn center","volume":"13","author":"Williams","year":"2009","journal-title":"Crit Care"},{"issue":"9424","key":"2024111510195426800_CIT0035","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/S0140-6736(04)16360-5","article-title":"Support of the metabolic response to burn injury","volume":"363","author":"Herndon","year":"2004","journal-title":"Lancet"},{"issue":"4","key":"2024111510195426800_CIT0036","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41590-018-0064-8","article-title":"Innate immune responses to trauma","volume":"19","author":"Huber-Lang","year":"2018","journal-title":"Nat Immunol"},{"key":"2024111510195426800_CIT0037","doi-asserted-by":"publisher","first-page":"621222","DOI":"10.3389\/fimmu.2020.621222","article-title":"Persistent systemic inflammation in patients with severe burn injury is accompanied by influx of immature neutrophils and shifts in T cell subsets and cytokine profiles","volume":"11","author":"Mulder","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"2024111510195426800_CIT0038","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.burns.2016.10.001","article-title":"Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation","volume":"43","author":"Rani","year":"2017","journal-title":"Burns"},{"issue":"13","key":"2024111510195426800_CIT0039","doi-asserted-by":"publisher","first-page":"7020","DOI":"10.3390\/ijms22137020","article-title":"The role of damps in burns and hemorrhagic shock immune response: pathophysiology and clinical issues. Review","volume":"22","author":"Pantalone","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2024111510195426800_CIT0040","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.4049\/jimmunol.2000439","article-title":"Damage-associated molecular patterns and the systemic immune consequences of severe thermal injury","volume":"205","author":"Comish","year":"2020","journal-title":"J Immunol"},{"key":"2024111510195426800_CIT0041","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fcell.2019.00198","article-title":"Aggregated and hyperstable damage-associated molecular patterns are released during ER stress to modulate immune function","volume":"7","author":"Andersohn","year":"2019","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"2024111510195426800_CIT0042","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.burns.2014.05.008","article-title":"Anti-inflammative effect of glycyrrhizin on rat thermal injury via inhibition of high-mobility group box 1 protein","volume":"41","author":"Shen","year":"2015","journal-title":"Burns"},{"key":"2024111510195426800_CIT0043","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1742-2094-8-118","article-title":"Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury","volume":"8","author":"Zhang","year":"2011","journal-title":"J Neuroinflammation"},{"issue":"2","key":"2024111510195426800_CIT0044","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/SHK.0000000000000752","article-title":"Burn injury alters epidermal cholinergic mediators and increases HMGB1 and caspase 3 in autologous donor skin and burn margin","volume":"47","author":"Holmes","year":"2017","journal-title":"Shock"},{"issue":"8","key":"2024111510195426800_CIT0045","doi-asserted-by":"publisher","first-page":"e103723","DOI":"10.1371\/journal.pone.0103723","article-title":"Role for heat shock protein 90\u03b1 in the proliferation and migration of HaCaT cells and in the deep second-degree burn wound healing in mice","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"2024111510195426800_CIT0046","doi-asserted-by":"publisher","first-page":"e23031","DOI":"10.1096\/fj.202202001RR","article-title":"LSD1 interacting with HSP90 promotes skin wound healing by inducing metabolic reprogramming of hair follicle stem cells through the C-MYC\/LDHA axis","volume":"37","author":"Li","year":"2023","journal-title":"FASEB J"},{"issue":"2","key":"2024111510195426800_CIT0047","doi-asserted-by":"publisher","first-page":"194","DOI":"10.5021\/ad.2017.29.2.194","article-title":"Serial changes of heat shock protein 70 and interleukin-8 in burn blister fluid","volume":"29","author":"Yoo","year":"2017","journal-title":"Ann Dermatol"},{"issue":"3","key":"2024111510195426800_CIT0048","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/01.PCC.0000161075.97355.2E","article-title":"Extracellular HSP70 levels in children with septic shock","volume":"6","author":"Wheeler","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"2024111510195426800_CIT0049","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1476-9255-7-30","article-title":"Fas (CD95) induces rapid, TLR4\/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages","volume":"7","author":"Wang","year":"2010","journal-title":"J Inflamm (Lond)"},{"key":"2024111510195426800_CIT0050","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12974-015-0389-2","article-title":"HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas\/FasL activation-dependent","volume":"12","author":"Jiang","year":"2015","journal-title":"J Neuroinflammation"},{"key":"2024111510195426800_CIT0051","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.3389\/fimmu.2020.01104","article-title":"HMGB1\/PI3K\/AKT\/mTOR signaling participates in the pathological process of acute lung injury by regulating the maturation and function of dendritic cells","volume":"11","author":"Li","year":"2020","journal-title":"Front Immunol"},{"issue":"17","key":"2024111510195426800_CIT0052","doi-asserted-by":"publisher","first-page":"eaaz9691","DOI":"10.1126\/sciadv.aaz9691","article-title":"Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement","volume":"6","author":"Kim","year":"2020","journal-title":"Sci Adv"},{"issue":"9","key":"2024111510195426800_CIT0053","doi-asserted-by":"publisher","first-page":"a011189","DOI":"10.1101\/cshperspect.a011189","article-title":"PI3K-PKB\/AKT pathway","volume":"4","author":"Hemmings","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"2024111510195426800_CIT0054","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1189\/jlb.1208763","article-title":"TLR4\/MYD88\/PI3K interactions regulate TLR4 signaling","volume":"85","author":"Laird","year":"2009","journal-title":"J Leukoc Biol"},{"issue":"6","key":"2024111510195426800_CIT0055","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1002\/JLB.2MIR0817-349R","article-title":"The PI3K\/AKT signaling pathway in regulatory T-cell development, stability, and function","volume":"103","author":"Pompura","year":"2018","journal-title":"J Leukoc Biol"},{"issue":"6","key":"2024111510195426800_CIT0056","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.bbalip.2014.12.006","article-title":"PI3K signalling in inflammation","volume":"1851","author":"Hawkins","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2024111510195426800_CIT0057","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3389\/fimmu.2012.00245","article-title":"The role of the PI3K signaling pathway IN CD4+ T cell differentiation and function","volume":"3","author":"Han","year":"2012","journal-title":"Front Immunol"},{"issue":"6","key":"2024111510195426800_CIT0058","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1002\/eji.201040945","article-title":"A class IA PI3K controls inflammatory cytokine production in human neutrophils","volume":"41","author":"Fortin","year":"2011","journal-title":"Eur J Immunol"},{"issue":"4","key":"2024111510195426800_CIT0059","doi-asserted-by":"publisher","first-page":"e94496","DOI":"10.1371\/journal.pone.0094496","article-title":"Identification of a role for the PI3K\/AKT\/mTOR signaling pathway in innate immune cells","volume":"9","author":"Xie","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"2024111510195426800_CIT0060","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.1128\/IAI.05303-11","article-title":"The phosphoinositide-3-kinase\u2013AKT signaling pathway is important for Staphylococcus aureus internalization by endothelial cells","volume":"79","author":"Oviedo-Boyso","year":"2011","journal-title":"Infect Immun"},{"issue":"10","key":"2024111510195426800_CIT0061","doi-asserted-by":"publisher","first-page":"8688","DOI":"10.1074\/jbc.M110.141754","article-title":"Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1","volume":"286","author":"Hutchinson","year":"2011","journal-title":"J Biol Chem"},{"key":"2024111510195426800_CIT0062","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fnmol.2015.00075","article-title":"Ribosomal protein S6 phosphorylation in the nervous system: from regulation to function","volume":"8","author":"Biever","year":"2015","journal-title":"Front Mol Neurosci"},{"issue":"12","key":"2024111510195426800_CIT0063","doi-asserted-by":"publisher","first-page":"E1397","DOI":"10.1152\/ajpendo.00064.2014","article-title":"mTORC1 AND JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading","volume":"306","author":"Martin","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024111510195426800_CIT0064","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","article-title":"Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases","volume":"148","author":"Beurel","year":"2015","journal-title":"Pharmacol Ther"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irae111\/58383447\/irae111.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/45\/6\/1607\/60679010\/irae111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/45\/6\/1607\/60679010\/irae111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T10:20:04Z","timestamp":1731666004000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/45\/6\/1607\/7691336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":64,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,12]]},"published-print":{"date-parts":[[2024,11,14]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irae111","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,6,12]]}}}