{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:09:37Z","timestamp":1793678977976,"version":"4.5.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971834"],"award-info":[{"award-number":["81971834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Marjolin\u2019s ulcer (MU) is a rare, aggressive skin tumor. There are numerous case reports but large long-term studies are lacking, necessitating further exploration of its treatment. This study aimed to summarize and analyze the characteristics, treatment methods, and prognosis of MU. We retrospectively analyzed the clinical data of 126 patients with MU, treated between January 2013 and January 2023 at the burn center. Demographic data, clinical characteristics, treatment, and prognosis were statistically analyzed. Of the 126 included patients, 104 were followed up for 0.1\u201310.2 years. The most common cause of the primary injury was flame burn (50.8%). Lesions were commonly observed on the lower limbs (47.6%). The predominant histopathological type was squamous cell carcinoma (92.8%). Among the 126 patients, 35 (27.8%) presented with bone invasion, 37 (29.4%) presented with enlarged lymph nodes, and 9 (7.1%) had lymph node metastasis. Extensive local excision (83.3%) was the most common surgical procedure; the defect was repaired using skin grafting (41.9%), free flaps (37.1%), and local flaps (21.0%). Multivariate analysis revealed that bone invasion and lymph node involvement were risk factors for postoperative recurrence. Survival analysis showed that age, latency period, pathological type, and recurrence were significant risk factors for survival. Extensive local resection is necessary to eradicate tumors, and patient follow-up should be more frequent within 1 year postoperatively. As MU is preventable, it is essential to reach a quick diagnosis and avoid delayed management before the occurrence of deadly metastases.<\/jats:p>","DOI":"10.1093\/jbcr\/irae139","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T16:43:51Z","timestamp":1720716231000},"page":"208-217","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Characteristics and Treatment of Marjolin\u2019s Ulcer at a Major Burn Center in Northwest China: A Retrospective Review of 126 Cases"],"prefix":"10.1093","volume":"46","author":[{"given":"Yuming","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shaanxi 710032 ,","place":["China"]},{"name":"Department of Graduate Department, Xi\u2019an Medical University , Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Health Service Management and Medical Education, School of Military Preventive Medicine, Fourth Military Medical University , Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1713-1005","authenticated-orcid":false,"given":"Qiying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shaanxi 710032 ,","place":["China"]},{"name":"Department of Graduate Department, Xi\u2019an Medical University , Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Health Service Management and Medical Education, School of Military Preventive Medicine, Fourth Military Medical University , Xi\u2019an, Shaanxi 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