{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:35:40Z","timestamp":1774956940446,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin D deficiency appears to be more prevalent than previously considered in the adult critically ill population, specifically burn-injured patients. No definitive regimen has been shown to restore vitamin D (25(OH)D) levels more effectively to therapeutic levels in the burn-injured population. The purpose of this study was to investigate the effects of either ergocalciferol (D2, 50 000 IU weekly) or cholecalciferol (D3, 6000 IU daily) in adults with burns \u226510% TBSA. This retrospective, observational study (2020-2022) included patients with vitamin D insufficiency (&amp;lt;30 ng\/mL) who received replacement and monitoring with weekly vitamin D levels. Patients on dialysis or those with a hospital length of stay less than 2 weeks were excluded. Forty-five patients treated with ergocalciferol and 99 patients with cholecalciferol were included in the study. Patients treated with cholecalciferol were more likely to achieve 25(OH)D levels greater than 30 ng\/mL compared to ergocalciferol over a 42-day period (HR 23.56, [95% CI, 12.57-44.16], P &amp;lt; .0001). A higher proportion of patients in the cholecalciferol group achieved vitamin D greater than 20 ng\/mL (HR 6.37, [95% CI, 4.20-9.66], P &amp;lt; .0001). The adjusted hazard ratios (D3 vs D2) for achieving 25(OH)D levels &amp;gt; 30 ng\/mL and &amp;gt; 20 ng\/mL were and 23.94 (95% CI 5.09-427.6, P = .0019) and 7.32 (95% CI, 3.83-15.52, P &amp;lt; .0001) respectively, after controlling for TBSA and initial 25(OH)D. Cholecalciferol appears to be a more effective agent than ergocalciferol for correcting vitamin D deficiency and insufficiency in patients with burn injuries.<\/jats:p>","DOI":"10.1093\/jbcr\/irae149","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T07:27:52Z","timestamp":1722065272000},"page":"171-177","source":"Crossref","is-referenced-by-count":1,"title":["Cholecalciferol and Ergocalciferol Replacement in Critically Injured Burn Patients: An Observational Cohort Study"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0620-3353","authenticated-orcid":false,"given":"Kees","family":"Vanderwyk","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of California Davis Health , Sacramento, CA 95817 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,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-8046","authenticated-orcid":false,"given":"Jessica","family":"La Force","sequence":"additional","affiliation":[{"name":"Food and Nutrition Services, University of California Davis Health , Sacramento, CA 95817 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9828-8688","authenticated-orcid":false,"given":"Molly","family":"Alexander","sequence":"additional","affiliation":[{"name":"Patient Care Services, University of California Davis Health , Sacramento, CA 95817 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soman","family":"Sen","sequence":"additional","affiliation":[{"name":"Burn Surgery, University of California Davis Health , Sacramento, CA 95817 ,","place":["USA"]},{"name":"Shriner's Hospital for Children Northern California , Sacramento, CA 95817 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