{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T08:40:01Z","timestamp":1756543201421,"version":"3.44.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060349"],"award-info":[{"award-number":["82060349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pathological scar (PS), encompassing hypertrophic scars (HS) and keloids, significantly impacts skin morphology and functions. Evidence suggests both exhibit hyperactive immune-inflammatory responses, yet research remains limited. This study used bioinformatics to explore shared genes and immune response characteristics in PS. Transcriptomic datasets (GSE181540 and GSE158395) were explored to investigate differentially expressed genes (DEGs) between normal skin and HS\/ keloids using the \u201climma\u201d package. Overlapping up- and downregulated genes were visualized via a Venn diagram and subjected to GO and KEGG enrichment to highlight immune-related processes, particularly in chemotaxis, indicating immune response abnormalities in both scar types. Differentially expressed immune-associated genes (DEIGs) were identified by overlapping DEGs with immune-associated genes. Seventy-eight DEIGs were mapped to protein-protein interaction (PPI) networks, revealing VCAM1, THBS1, and SERPINE1 as the key hub genes. Immunohistochemical staining showed these genes were highly expressed in keloid and HS tissues but expressed at lower levels in normal skin. Ultimately, immune cell infiltration analysis unveiled increased immune cell proportions in HS and keloids, with keloid tissue displaying higher immune cell abundance.<\/jats:p>","DOI":"10.1093\/jbcr\/iraf046","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:11:21Z","timestamp":1744477881000},"page":"870-885","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Shared Genes and Immune Profiling for Pathological Scar"],"prefix":"10.1093","volume":"46","author":[{"given":"Shuqian","family":"Dou","sequence":"first","affiliation":[{"name":"Kunming Medical University , Kunming ,","place":["China"]},{"name":"The Second Affiliated Hospital of Kunming Medical University , Kunming ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1098-815X","authenticated-orcid":false,"given":"Yue","family":"Deng","sequence":"additional","affiliation":[{"name":"Kunming Medical University , Kunming ,","place":["China"]},{"name":"The Second Affiliated Hospital of Kunming Medical University , Kunming ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"Kunming Medical University , Kunming ,","place":["China"]},{"name":"The Second Affiliated Hospital of Kunming Medical University , Kunming ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Kunming Medical University , Kunming ,","place":["China"]},{"name":"The Second Affiliated Hospital of Kunming Medical University , Kunming ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"2025083004164353300_CIT0001","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2133.2009.09258.x","article-title":"Genetic susceptibility to raised dermal scarring","volume":"161","author":"Brown","year":"2009","journal-title":"Br J Dermatol"},{"key":"2025083004164353300_CIT0002","doi-asserted-by":"crossref","first-page":"e408","DOI":"10.5435\/JAAOS-D-19-00690","article-title":"Keloid and hypertrophic scar formation, prevention, and management: standard review of abnormal scarring in orthopaedic surgery","volume":"28","author":"Grabowski","year":"2020","journal-title":"J Am Acad Orthop Surg"},{"key":"2025083004164353300_CIT0003","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/2000656X.2012.669184","article-title":"Formation of hypertrophic scars: evolution and susceptibility","volume":"46","author":"Mahdavian Delavary","year":"2012","journal-title":"J Plast Surg Hand Surg"},{"key":"2025083004164353300_CIT0004","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jid.2019.10.002","article-title":"Clinical Challenge and Call for Research on Keloid Disorder: Meeting Report from The 3rd International Keloid Research Foundation Symposium, Beijing 2019","volume":"140","author":"Uitto","year":"2020","journal-title":"J Invest Dermatol"},{"key":"2025083004164353300_CIT0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1272\/jnms.83.46","article-title":"Keloids and hypertrophic scars can now be cured completely: recent progress in our understanding of the pathogenesis of keloids and hypertrophic scars and the most promising current therapeutic strategy","volume":"83","author":"Ogawa","year":"2016","journal-title":"J Nippon Med. 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