{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:01:21Z","timestamp":1790074881458,"version":"4.0.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007865","name":"University of Texas Medical Branch","doi-asserted-by":"publisher","award":["TL1TR001440"],"award-info":[{"award-number":["TL1TR001440"]}],"id":[{"id":"10.13039\/100007865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Severe burn patients are prone to developing various musculoskeletal, dermatological, and cardiovascular complications, and hypothyroidism is associated with derangements of these same systems. This study aims to explore the association between hypothyroidism and the emergence of these complications in severe burn patients. Patients with severe burns, defined as those encompassing \u226520% total body surface area, were identified in the TriNetX US Collaborative Network and were categorized into 2 groups based on a history of hypothyroidism. Risk ratios (RRs) and differences of contractures, undergoing graft procedures, graft complications, amputations, and various infections and cardiovascular complications were generated using the database\u2019s measure of association analysis. The hypothyroidism cohort showed a greater risk of developing contractures (RR, 1.667; 95% confidence interval [CI], [1.207, 2.302]; P = .002), skin infections (RR, 1.885; CI, [1.192, 2.980]; P = .006), and urinary tract infections (RR, 1.950; CI, [1.155, 3.292]; P = .011) within 6 months of insult. The hypothyroidism cohort showed a decreased risk of mortality (RR, 0.688; CI, [0.516, 0.915]; P &amp;lt; .010), undergoing graft procedures (RR, 0.647; CI, [0.518, 0.807]; P &amp;lt; .001), and vasopressor use (RR, 0.806; CI, [0.667, 0.974]; P = .025) in this same time period. In conclusion, hypothyroidism in severe burn patients is associated with an increased risk of developing contractures and skin and urinary tract infections and a decreased risk of mortality, undergoing graft procedures, and vasopressor use.<\/jats:p>","DOI":"10.1093\/jbcr\/iraf090","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:18:09Z","timestamp":1747210689000},"page":"1326-1331","source":"Crossref","is-referenced-by-count":0,"title":["Hypothyroidism in Severe Burn Patients Associated with Increased Risk of Musculoskeletal Complications and Decreased Risk of Mortality"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9442-2252","authenticated-orcid":false,"given":"Isabel","family":"Obias","sequence":"first","affiliation":[{"name":"John Sealy School of Medicine, University of Texas Medical Branch , Galveston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-7222","authenticated-orcid":false,"given":"Dalton","family":"Amador","sequence":"additional","affiliation":[{"name":"John Sealy School of Medicine, University of Texas Medical Branch , Galveston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0744-9441","authenticated-orcid":false,"given":"Sudhanvan","family":"Iyer","sequence":"additional","affiliation":[{"name":"John Sealy School of Medicine, University of Texas Medical Branch , Galveston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-0633","authenticated-orcid":false,"given":"Amina","family":"El Ayadi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Medical Branch , Galveston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-2767","authenticated-orcid":false,"given":"George","family":"Golovko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Texas Medical Branch , Galveston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-3440","authenticated-orcid":false,"given":"Steven E","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Medical Branch , Galveston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-9078","authenticated-orcid":false,"given":"Juquan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Medical Branch , Galveston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"2026092206012902800_CIT0001","article-title":"Physiology, thyroid function. 2023 Mar 13","volume-title":"StatPearls [Internet]","author":"Armstrong","year":"2023"},{"key":"2026092206012902800_CIT0002","doi-asserted-by":"publisher","first-page":"124538","DOI":"10.1155\/2013\/124538","article-title":"Thyroid hormone and wound healing","volume":"2013","author":"Safer","year":"2013","journal-title":"J Thyroid Res"},{"key":"2026092206012902800_CIT0003","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2026092206012902800_CIT0004","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/jbcr\/irz034","article-title":"Amputation following burn injury","volume":"40","author":"Bartley","year":"2019","journal-title":"J Burn Care Res"},{"key":"2026092206012902800_CIT0005","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4248\/BR201302004","article-title":"Role and mechanisms of actions of thyroid hormone on the skeletal development","volume":"1","author":"Kim","year":"2013","journal-title":"Bone Res"},{"key":"2026092206012902800_CIT0006","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1530\/JOE-16-0611","article-title":"Role of thyroid hormone in skeletal muscle physiology","volume":"236","author":"Bloise","year":"2018","journal-title":"J Endocrinol"},{"key":"2026092206012902800_CIT0007","article-title":"Physiology, thyroid hormone. 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