{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T09:25:13Z","timestamp":1762680313761,"version":"build-2065373602"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Contrast therapy (CT), alternating cooling and heating therapy, has been investigated for its potential benefits in treating soft tissue injuries in sports. This study examines the efficacy of CT in enhancing skin scald repair. We established a standardized rat scald burn model and randomized the subjects into three groups: CT, cold therapy (COT), and untreated model control (MC). Interventions commenced immediately after injury. Cutaneous blood perfusion, tissue oxygen saturation, and wound healing rates were assessed. Inflammatory cytokine (IL-6, IL-1\u03b2, and TNF-\u03b1) quantification were measured by ELISA. Histological changes were analyzed by hematoxylin\u2013eosin and TUNEL staining. After 21\u00a0days\u2019 observation, CT demonstrated significant suppression of TNF-\u03b1 and IL-6 protein expression in burned tissue by day 3 post-burn. Additionally, CT enhanced localized blood perfusion at both wound center\/edge and increased oxygen saturation at wound edge post-treatment. The epithelial thickness in the CT group was greater than in the COT and MC groups, with a lower proportion of TUNEL-positive cells. The CT group also showed less ulceration and edema. The CT group had a higher wound healing rate on days 1, 7, and 14 post-burn compared to the other groups. In conclusion, CT ameliorates local blood microcirculation, reduces harmful inflammatory factors in scalded skin tissue, and accelerates wound healing. These findings suggest that CT may be a potentially effective treatment for acute scald injuries.<\/jats:p>","DOI":"10.1093\/jbcr\/iraf161","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:34:25Z","timestamp":1756208065000},"page":"1410-1419","source":"Crossref","is-referenced-by-count":0,"title":["Contrast Therapy Promoting Skin Scald Repair"],"prefix":"10.1093","volume":"46","author":[{"given":"Shuang","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou 510080 ,","place":["China"]},{"name":"School of Rehabilitation Medicine, Capital Medical University , Beijing 100068 ,","place":["China"]},{"name":"Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center , Beijing 100068 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqi","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine, Capital Medical University , Beijing 100068 ,","place":["China"]},{"name":"Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center , Beijing 100068 ,","place":["China"]},{"name":"Department of Rehabilitation Medicine, Foshan Hospital of Traditional Chinese Medicine , Foshan 528000 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Run","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine, Capital Medical University , Beijing 100068 ,","place":["China"]},{"name":"Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center , Beijing 100068 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine, Capital Medical University , Beijing 100068 ,","place":["China"]},{"name":"Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center , Beijing 100068 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine, Capital Medical University , Beijing 100068 ,","place":["China"]},{"name":"Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center , Beijing 100068 ,","place":["China"]},{"name":"Department of Rehabilitation Medicine, Peking University Third Hospital , Beijing 100191 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center , Beijing 100068 ,","place":["China"]},{"name":"Department of Rehabilitation Medicine Research, China Rehabilitation Science Institute , Beijing 100068 ,","place":["China"]},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation , Beijing 100068 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingliang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine, Capital Medical University , Beijing 100068 ,","place":["China"]},{"name":"Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center , Beijing 100068 ,","place":["China"]},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders 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