{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:40:44Z","timestamp":1785897644493,"version":"3.56.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Opioid use disorder (OUD) is a significant cause of unintentional burn injuries. Pain management in patients with OUD requires complex multi-modal treatment and places significant challenges on the patient and their clinical team. Buprenorphine has been well-established as a standard of care in the medical treatment of opioid use disorder. However, its use in surgical patients with significant co-morbid pain was felt to carry a risk for both worsened acute pain control and\/or precipitation of withdrawal. As treatment with buprenorphine carries considerable benefits, alternative approaches have been developed to facilitate buprenorphine introduction in the acute perioperative setting. We present a first-ever retrospective cohort review examining the use of low-dose buprenorphine in acute burn injury setting. The majority of our patient cohort (86%) was able to initiate buprenorphine without an adverse impact on pain, or emergence of precipitated withdrawal. All of these patients were able to transition to outpatient OUD care for buprenorphine prescribing. Incidentally, we also note that buprenorphine initiation was also associated with reduced opioid prescribing at discharge, with only 50% of our patient cohort requiring a brief short-acting taper in addition to buprenorphine. Further studies should address long-term outcomes in the patient population as well as how to best holistically manage patients with substance use disorder and concurrent burn injuries.<\/jats:p>","DOI":"10.1093\/jbcr\/iraf163","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T11:55:03Z","timestamp":1755777303000},"page":"1420-1425","source":"Crossref","is-referenced-by-count":1,"title":["Low-Dose Buprenorphine Initiation in Acute Burn Setting, a Retrospective Chart Review"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9048-7212","authenticated-orcid":false,"given":"Mladen","family":"Nisavic","sequence":"first","affiliation":[{"name":"Department of Burn Surgery, Massachusetts General Hospital , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Supple","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, Massachusetts General Hospital , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Requena","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, Massachusetts General Hospital , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashika","family":"Bains","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, Massachusetts General Hospital , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-852X","authenticated-orcid":false,"given":"Jeremy","family":"Goverman","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, Massachusetts General Hospital , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"2025110904213774100_ref1","volume-title":"U.S. Overdose Deaths Decrease in 2023, First Time Since 2018","author":"Centers for Disease Control and Prevention","year":"2024"},{"key":"2025110904213774100_ref2","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.burns.2022.08.008","article-title":"Opioid use disorder in adult burn patients: implications for future mental health, behavioral and substance use patterns","volume":"49","author":"Shah","year":"2023","journal-title":"Burns"},{"key":"2025110904213774100_ref3","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.burns.2021.07.018","article-title":"Opioid dependence and treatment outcomes among patients with burn injury","volume":"48","author":"Peluso","year":"2022","journal-title":"Burns"},{"key":"2025110904213774100_ref4","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1093\/jbcr\/iraa119","article-title":"American Burn Association guidelines on the management of acute pain in the adult burn patient: a review of the literature, a compilation of expert opinion, and next steps","volume":"41","author":"Romanowski","year":"2020","journal-title":"J Burn Care Res"},{"key":"2025110904213774100_ref5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/ADM.0000000000001236","article-title":"Evaluation of low-dose buprenorphine initiation with buprenorphine buccal films in hospitalized patients: a retrospective cohort study","volume":"18","author":"Arnouk","year":"2024","journal-title":"J Addict Med"},{"key":"2025110904213774100_ref6","doi-asserted-by":"publisher","first-page":"19com12810","DOI":"10.4088\/JCP.19com12810","article-title":"Perioperative buprenorphine continuous maintenance and administration simultaneous with full opioid agonist: patient priority at the interface between medical disciplines","volume":"81","author":"Acampora","year":"2020","journal-title":"J Clin Psychiatry"},{"key":"2025110904213774100_ref7","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1097\/ADM.0000000000000947","article-title":"Low dose buprenorphine induction with full agonist overlap in hospitalized patients with opioid use disorder: a retrospective cohort study","volume":"16","author":"Bhatraju","year":"2022","journal-title":"J Addict Med"},{"key":"2025110904213774100_ref8","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1097\/ADM.0000000000000864","article-title":"Low-dose buprenorphine initiation in hospitalized adults with opioid use disorder: a retrospective cohort analysis","volume":"16","author":"Button","year":"2022","journal-title":"J Addict Med"},{"key":"2025110904213774100_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109541","article-title":"Development of an intravenous low-dose buprenorphine initiation protocol","volume":"237","author":"Jablonski","year":"2022","journal-title":"Drug Alcohol Depend"},{"key":"2025110904213774100_ref10","doi-asserted-by":"publisher","first-page":"j1550","DOI":"10.1136\/bmj.j1550","article-title":"Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies","volume":"357","author":"Sordo","year":"2017","journal-title":"BMJ"},{"key":"2025110904213774100_ref11","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1001\/jamapsychiatry.2021.0976","article-title":"Association of opioid agonist treatment with all-cause mortality and specific causes of death among people with opioid dependence: a systematic review and meta-analysis","volume":"78","author":"Santo","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"2025110904213774100_ref12","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1111\/add.14991","article-title":"Opioid agonist treatment and fatal overdose risk in a state-wide US population receiving opioid use disorder services","volume":"115","author":"Krawczyk","year":"2020","journal-title":"Addiction"},{"key":"2025110904213774100_ref13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.drugalcdep.2009.03.020","article-title":"Comparing overdose mortality associated with methadone and buprenorphine treatment","volume":"104","author":"Bell","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"2025110904213774100_ref14","author":"Morphine Milligram Equivalent Calculator"},{"key":"2025110904213774100_ref15","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1136\/rapm-2021-103007","article-title":"Buprenorphine management in the perioperative period: educational review and recommendations from a multisociety expert panel","volume":"46","author":"Kohan","year":"2021","journal-title":"Reg Anesth Pain Med"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/iraf163\/64107377\/iraf163.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/46\/6\/1420\/64107377\/iraf163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/46\/6\/1420\/64107377\/iraf163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T09:21:43Z","timestamp":1762680103000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/46\/6\/1420\/8239682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,8,22]]},"published-print":{"date-parts":[[2025,11,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/iraf163","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,8,22]]}}}