{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:53:04Z","timestamp":1790970784861,"version":"4.1.0"},"reference-count":101,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fractional ablative laser (FAL) is a minimally invasive method of hypertrophic scar management first introduced in 2004. Laser technologies and techniques have continued to evolve since that time and have included the addition of laser-assisted drug delivery (LADD) to augment the effects of the laser on scars. Laser-assisted drug delivery is increasingly reported in the literature and standard treatment protocols, underscoring the popularity of this technique among clinicians. Given this popularity, it is important to scrutinize evidence relating to the clinical outcomes LADD may achieve for patients. This scoping review examined literature relating to LADD for the treatment of hypertrophic scars in humans, aiming to clarify what clinical outcomes are achieved with its use and examining how these outcomes were studied and measured. PubMed, EMBASE, Cochrane, the WHO International Clinical Trials Registry and ClinicalTrials.gov were systematically searched, and data about study methodology, outcome measurement tools and results were extracted. Fifty-five publications that discussed LADD for the treatment of hypertrophic scars in humans were identified. Sixteen different substances, most frequently corticosteroids, were used for LADD treatment of hypertrophic scars, most often in conjunction with a carbon dioxide FAL. Study designs, outcome measurement strategies and follow-up time-frames were highly variable, as were the patient outcomes achieved. The clinical outcomes achieved with LADD are unclear, largely due to the variability of study methodology and outcome measurement. The efficacy of this technique requires further investigation with robustly designed, large trials which have comparison groups and use validated scar outcome measurement tools.<\/jats:p>","DOI":"10.1093\/jbcr\/iraf167","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T12:07:15Z","timestamp":1757678835000},"page":"130-146","source":"Crossref","is-referenced-by-count":4,"title":["Laser-Assisted Drug Delivery for Hypertrophic Scar Treatment: A Scoping Review"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6890-6587","authenticated-orcid":false,"given":"Maria","family":"Shilova","sequence":"first","affiliation":[{"name":"School of Nursing and Midwifery, Griffith University , Gold Coast 4111 ,","place":["Australia"]},{"name":"School of Medicine and Dentistry, Griffith University , Gold Coast 4215 ,","place":["Australia"]},{"name":"Queensland Children\u2019s Hospital , South Brisbane 4101 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6020-6508","authenticated-orcid":false,"given":"Karin","family":"Plummer","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery, Griffith University , Gold Coast 4111 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-6736","authenticated-orcid":false,"given":"Robert","family":"Ware","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University , Gold Coast 4215 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-7707","authenticated-orcid":false,"given":"Roy","family":"Kimble","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University , Gold Coast 4215 ,","place":["Australia"]},{"name":"Queensland Children\u2019s Hospital , South Brisbane 4101 ,","place":["Australia"]},{"name":"Centre for Children\u2019s Burns and Trauma Research, Queensland Children\u2019s Hospital , South Brisbane 4101 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0133-1613","authenticated-orcid":false,"given":"Justin","family":"Clark","sequence":"additional","affiliation":[{"name":"Institute for Evidence-Based Healthcare, Bond University , Robina 4226 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3192-0405","authenticated-orcid":false,"given":"Esther","family":"Cho","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University , Gold Coast 4215 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7772-6102","authenticated-orcid":false,"given":"Lucinda","family":"McMillan","sequence":"additional","affiliation":[{"name":"School of Health and Rehabilitation Sciences, University of Queensland , St Lucia 4067 ,","place":["Australia"]},{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland , St Lucia 4072 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kimble","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine, University of Queensland , St Lucia 4072 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-3589","authenticated-orcid":false,"given":"Brandon","family":"Meikle","sequence":"additional","affiliation":[{"name":"Centre for Children\u2019s Burns and Trauma Research, Queensland Children\u2019s Hospital , South Brisbane 4101 ,","place":["Australia"]},{"name":"Children\u2019s Health Research Centre, Faculty of Medicine, The University of Queensland , Herston 4006 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kunde","sequence":"additional","affiliation":[{"name":"Queensland Children\u2019s Hospital , South Brisbane 4101 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-9125","authenticated-orcid":false,"given":"Bronwyn","family":"Griffin","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery, Griffith University , Gold Coast 4111 ,","place":["Australia"]},{"name":"Centre for Children\u2019s Burns and Trauma Research, Queensland Children\u2019s Hospital , South Brisbane 4101 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