{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:21:49Z","timestamp":1772778109475,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with major burn injuries are at high risk of venous thromboembolism. In 2022, a new prophylaxis guideline was introduced for adults with burns \u2265 20% total body surface area: enoxaparin 40\u00a0mg twice daily, renally, and weight adjusted. This quality improvement study assessed compliance and outcomes by comparing patients admitted postguideline (January 2022\u2013December 2023) to a preguideline cohort (July 2019\u2013June 2021) who received enoxaparin 40\u00a0mg daily. Among 138 actively treated patients (77% male, median age 43\u00a0years, and median % total body surface area 35), 57 were treated preguideline and 45 post, with no major differences between groups. Preguideline, 5 patients developed venous thromboembolic complications (2 pulmonary emboli, 3 deep vein thromboses) versus 3 incidental thromboembolisms (1 pulmonary embolus, 2 deep vein thromboses) postguideline. Transfusion for bleeding was similar across groups, but major bleeding affecting dermal substitute application increased from 1 case (2%) preguideline to 7 cases (15%) postguideline, this difference was not statistically significant. To mitigate this, intravenous tranexamic acid and increased transfusion rates were implemented after 12\u00a0months, eliminating major bleeding events in the subsequent period. Overall, 88% of patients received venous thromboembolic prophylaxis in line with the guideline. Despite an initial increase in bleeding complications, intraoperative adjustments resolved these issues, demonstrating a learning curve. The guideline was successfully implemented and appears effective in reducing venous thromboembolic risk with acceptable complications.<\/jats:p>","DOI":"10.1093\/jbcr\/iraf198","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:04:33Z","timestamp":1760097873000},"page":"590-597","source":"Crossref","is-referenced-by-count":0,"title":["Burn-Specific Venous Thromboembolism Prophylaxis: A 2-Year Quality Improvement Project"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-3610","authenticated-orcid":false,"given":"Guy","family":"Sheahan","sequence":"first","affiliation":[{"name":"Department of Victorian Adult Burns Service, Alfred Hospital , 55 Commercial Rd, Melbourne, Victoria 3004 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