{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T09:25:07Z","timestamp":1766568307833,"version":"3.48.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Health and Social Care Research, Surgical Reconstruction and Microbiology Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Evaluate the effectiveness and tolerability of 0.5% and 2.0% (w\/v) acetic acid on colonized burns wounds for 3 days after hospital admission. Burn wound infection and secondary sepsis are serious complications. Due to growing bacterial resistance worldwide, effective antimicrobial agents that do not increase the risk of resistance and are non-toxic are required. In this phase II trial, 0.5% or 2.0% acetic acid was applied to burns colonized by specifically identifiable bacteria. Participants aged \u2265 16\u00a0years with burns \u2265 1% BSA were randomly assigned 1:1. Efficacy was measured by change in bacterial load from swabs taken daily for 4 consecutive days. The study encountered 2 interruptions during the COVID-19 pandemic lockdown. Consequently, major protocol amendments were implemented to ensure alignment with established hospital clinical pathways. Between February 2018 and October 2021, 22 participants were randomized. Participant characteristics were balanced, except fewer full-thickness burns in the 2.0% acetic acid group. Two percent acetic acid significantly decreased the bacterial load compared to 0.5% concentration (P = .0129) but also increased the pain score (P = .012). Only one serious adverse event occurred: a grade 3 urinary tract infection unrelated to acetic acid, which resolved without sequelae. Acetic acid was safe and well-tolerated. Both concentrations lowered bacterial load, with 2.0% proving more effective. The study also indicates that dressing changes every 12\u00a0h may be required.<\/jats:p>\n                  <jats:p>Clinical trial registration: EudraCT: 2017-003481-28. ISRCTN 11636684.<\/jats:p>","DOI":"10.1093\/jbcr\/iraf228","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:55:16Z","timestamp":1765976116000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Optimal Dose of Acetic Acid for Treating Colonized Burns Wounds (AceticA): A Double-Blind, Single-Center, Randomized, Controlled Phase II Trial"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-5138","authenticated-orcid":false,"given":"Naiem","family":"Moiemen","sequence":"first","affiliation":[{"name":"University Hospitals NHS foundation Trust , Burn Centre, Mindelsohn Way, Edgbaston, Birmingham B15 2GW ,","place":["United Kingdom"]},{"name":"College of Medicine and Health, School of Infection, Inflammation and Immunology, University of Birmingham , Birmingham B15 2TT ,","place":["United 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