{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:45:09Z","timestamp":1789393509648,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Military Burn Research Program"},{"name":"Clinical Translational Research Award","award":["MB200032"],"award-info":[{"award-number":["MB200032"]}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM008315"],"award-info":[{"award-number":["T32 GM008315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Growing evidence supports the addition of fresh frozen plasma (FFP) to a standardized crystalloid-based burn resuscitation. Fresh frozen plasma is thought to mitigate endotheliopathy, decrease total fluids and improve outcomes; however, when and how much FFP to give remains controversial. Here, we assessed the safety and efficacy of adding a non-titratable, 8-hr FFP infusion of 0.5\u00a0mL\/kg\/% total body surface area (TBSA) to a burn resuscitation. We performed an unmatched retrospective cohort review on all patients with burn injuries aged &amp;gt;\u200918\u00a0years old with &amp;gt;\u200920% TBSA burns who underwent our nursing-driven resuscitation protocol that included this early, standardized FFP infusion, from November 2016 to May 2020. Fifty-three patients received FFP and met inclusion criteria. Patients were primarily male (85%), with a median age of 36\u00a0years and a TBSA burn of 39% (range 24.5%-94%). Median time to FFP administration was 7\u00a0h from injury with a median of 1517\u00a0mL infused. Median input\/output (I\/O) ratio improved from 0.8 at FFP initiation to 0.4 at 3\u00a0h post-FFP, P &amp;lt; .001. Median urine output (UOP) improved from 0.19\u00a0mL\/kg\/h prior to FFP administration to 0.52\u00a0mL\/kg\/h at 3\u00a0h post-FFP, P &amp;lt; .001. No complications related to resuscitation such as abdominal compartment syndrome, acute respiratory distress syndrome, or transfusion reactions occurred. Therefore, adding a low-dose, standardized FFP infusion to burn resuscitations significantly improved UOP, normalized I\/O ratios, and did not cause any known complications. Standardizing a safe, effective, non-titratable FFP infusion provides the framework to systematically test how colloids can be optimized during burn resuscitations in the future.<\/jats:p>","DOI":"10.1093\/jbcr\/iraf233","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:27:17Z","timestamp":1767083237000},"page":"807-816","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Efficacy of an Early Low-Dose Fresh Frozen Plasma Infusion in Burn Resuscitation"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3657-7504","authenticated-orcid":false,"given":"Arek J","family":"Wiktor","sequence":"first","affiliation":[{"name":"UCHealth Burn and Frostbite Center, University of Colorado Hospital Anschutz Inpatient Pavilion , Aurora, CO 80045 ,","place":["United States"]},{"name":"Division of GI, Trauma\/Burn, and Endocrine Surgery (GITES), Department of Surgery, University of Colorado Anschutz Medical Campus Academic Office One , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-8248","authenticated-orcid":false,"given":"Thomas O","family":"Vogler","sequence":"additional","affiliation":[{"name":"UCHealth Burn and Frostbite Center, University of Colorado Hospital Anschutz Inpatient Pavilion , Aurora, CO 80045 ,","place":["United States"]},{"name":"Division of GI, Trauma\/Burn, and Endocrine Surgery (GITES), Department of Surgery, University of Colorado Anschutz Medical Campus Academic Office One , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-8247","authenticated-orcid":false,"given":"Heather","family":"Carmichael","sequence":"additional","affiliation":[{"name":"Division of GI, Trauma\/Burn, and Endocrine Surgery (GITES), Department of Surgery, University of Colorado Anschutz Medical Campus Academic Office One , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munib","family":"Far","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Colorado School of Medicine , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-8199","authenticated-orcid":false,"given":"Scott W","family":"Mueller","sequence":"additional","affiliation":[{"name":"UCHealth Burn and Frostbite Center, University of Colorado Hospital Anschutz Inpatient Pavilion , Aurora, CO 80045 ,","place":["United States"]},{"name":"UCHealth Department of Pharmacy, University of Colorado Hospital Anschutz Inpatient Pavilion , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"2026050508231202200_ref1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/jbcr\/irz184","article-title":"A review on the use of plasma during acute burn resuscitation","volume":"41","author":"Cartotto","year":"2020","journal-title":"J Burn Care Res"},{"key":"2026050508231202200_ref2","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.4103\/0970-0358.70715","article-title":"Fluid management in major burn injuries","volume":"43","author":"Haberal","year":"2010","journal-title":"Indian J Plast Surg"},{"key":"2026050508231202200_ref3","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1097\/00000658-195206000-00006","article-title":"Fluid and electrolyte requirements in severe burns","volume":"135","author":"Evans","year":"1952","journal-title":"Ann 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