{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:18:37Z","timestamp":1777987117583,"version":"3.51.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Frailty is a clinical state characterized by increased vulnerability to stressors, leading to an increased risk of adverse health outcomes. The modified Frailty Index (mFI-5), based on 5 comorbidities\u2014diabetes mellitus, heart failure, pulmonary disease, hypertension, and totally or partially dependent functional health status\u2014has shown predictive value for treatment outcomes and mortality. The primary objective of this study was to evaluate differences in clinical outcomes between patients with burn injuries who have mFI-5 scores of 0, 1, and\u2009\u2265\u20092. The secondary objective was to determine whether the mFI-5 score independently predicts adverse outcomes. A retrospective analysis of 644 patients with burn injuries treated between September 2018 and May 2022 was conducted. Data on comorbidities, complications, ventilation status, surgical procedures, length of stay, and discharge destination were analyzed. Statistical analyses included Pearson\u2019s chi-square test, Kruskal\u2013Wallis test, and adjusted multivariate regression analysis. Higher mFI-5 scores were associated with worse overall outcomes, including longer hospital stays, higher rates of complications, more frequent need for mechanical ventilation, a greater number of skin grafts and necrectomies, and more frequent discharge to nonhome settings. Multivariate analyses showed that a higher mFI-5 score compared to mFI-5\u2009=\u20090 was independently associated with higher rates of urinary tract infections (mFI-5\u2009\u2265\u20092: odds ratio [OR] 2, 41, 95% CI, 1.19-4.86; P = .014) and nonhome discharge (mFI-5\u2009=\u20091: OR 2.34; 95% CI, 1.00-5.45; P = .049). The mFI-5 is a strong predictor of complications and adverse outcomes in patients with burn injuries. Its quick, simple application makes it a valuable risk stratification tool in specialized burn centers.<\/jats:p>","DOI":"10.1093\/jbcr\/irag019","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:39:25Z","timestamp":1770295165000},"page":"879-884","source":"Crossref","is-referenced-by-count":0,"title":["Association Between the Modified Frailty Index-5 and Clinical Outcomes in Burn Patients"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3810-6662","authenticated-orcid":false,"given":"Jule","family":"Schmiechen","sequence":"first","affiliation":[{"name":"Department of Trauma Surgery and Orthopedics, University Hospital Hamburg-Eppendorf , Martinistra\u00dfe 52, Hamburg 20246 ,","place":["Germany"]},{"name":"Department of Hand-, Plastic and Microsurgery, Burn Unit, Berufsgenossenschaftliches Klinikum , Bergedorfer Stra\u00dfe 10, Hamburg 21033 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-8752","authenticated-orcid":false,"given":"Thomas","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Plastic and Hand Surgery, Burn Unit, Klinikum St. Georg , Delitzscher Stra\u00dfe 141, Leipzig 04129 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-1856","authenticated-orcid":false,"given":"Susanne","family":"Rein","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery and Orthopedics, University Hospital Hamburg-Eppendorf , Martinistra\u00dfe 52, Hamburg 20246 ,","place":["Germany"]},{"name":"Department of Hand-, Plastic and Microsurgery, Burn Unit, Berufsgenossenschaftliches Klinikum , Bergedorfer Stra\u00dfe 10, Hamburg 21033 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"2026050508230178800_ref1","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.jamda.2013.03.022","article-title":"Frailty consensus: a call to action","volume":"14","author":"Morley","year":"2013","journal-title":"J Am Med Dir Assoc"},{"key":"2026050508230178800_ref2","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/j.1532-5415.2006.00745.x","article-title":"Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society\/National Institute on Aging Research Conference on Frailty in Older Adults","volume":"54","author":"Walston","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"2026050508230178800_ref3","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","volume-title":"Lancet","author":"Clegg","year":"2013"},{"key":"2026050508230178800_ref4","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1093\/gerona\/62.7.722","article-title":"Frailty in relation to the accumulation of deficits","volume":"62","author":"Rockwood","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2026050508230178800_ref5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.5114\/ait.2020.101220","article-title":"A response to comment on prognostic factors in burns","volume":"53","author":"Zieli\u0144ski","year":"2021","journal-title":"Anaesthesiol Intensive Ther"},{"key":"2026050508230178800_ref6","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1159\/000534131","article-title":"Is frailty different in younger adults compared to old? 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