{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:18:29Z","timestamp":1777987109406,"version":"3.51.4"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hyperbaric oxygen therapy (HBOT) involves inhaling 100% oxygen at pressures exceeding one atmosphere within a chamber. It is used across several specialties and has been proposed as an adjunct in burn management to enhance healing and improve outcomes. Despite increasing interest, evidence supporting its efficacy in burn care remains inconsistent, with no clear consensus in practice. A literature search was conducted in September 2025 across PubMed, Cochrane Library, and Embase without date restrictions to identify studies evaluating HBOT for burn treatment. Inclusion criteria were human studies, English-language articles, and full-text availability. Study selection followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two reviewers screened titles and abstracts, and a third resolved discrepancies. Eligible studies described HBOT as a burn treatment and reported clinical outcomes. Thirteen studies met inclusion criteria: 5 randomized controlled trials, 7 cohort studies, and 1 case\u2013control study, evaluating 566 burn patients. Burn severity, HBOT protocols, and outcomes varied substantially. Several studies reported reduced need for surgery and shorter hospital stays with HBOT. Trends toward improved healing and lower infection risk were noted, while mortality benefits were inconsistent. Heterogeneity in design and treatment regimens limited synthesis via meta-analysis. Hyperbaric oxygen therapy shows promise as an adjunct in burn care, improving healing and reducing complications. However, variability and inconsistent outcomes limit definitive conclusions. Well-designed randomized trials are needed to establish standardized protocols and clarify their clinical role in burn management. Until then, burn centers may consider HBOT for acute injuries and threatened grafts.<\/jats:p>","DOI":"10.1093\/jbcr\/irag026","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:28:16Z","timestamp":1771331296000},"page":"917-922","source":"Crossref","is-referenced-by-count":0,"title":["Hyperbaric Oxygen Therapy in Burn Care: A Systematic Review of Current Evidence"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-4686","authenticated-orcid":false,"given":"Julissa","family":"Molina-Vega","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA 90095 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E","family":"Pferdehirt","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of California Los Angeles , Los Angeles, CA 90095 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9764-8029","authenticated-orcid":false,"given":"Andrew J","family":"Vardanian","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, University of California Los Angeles , Los Angeles, CA 90095 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"2026050508221941400_ref1","volume-title":"UHMS Hyperbaric Medicine Indications Manual","author":"Huang","year":"2023","edition":"15th"},{"key":"2026050508221941400_ref2","first-page":"247","article-title":"Mechanisms of action of hyperbaric oxygen therapy","volume":"41","author":"Camporesi","year":"2018","journal-title":"Undersea Hyperb Med"},{"key":"2026050508221941400_ref3","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.burns.2016.10.016","article-title":"Adjunctive hyperbaric oxygen therapy in severe burns: experience in Taiwan Formosa Water Park dust explosion disaster","volume":"43","author":"Chiang","year":"2017","journal-title":"Burns."},{"key":"2026050508221941400_ref4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00004630-198909000-00012","article-title":"Adjunctive hyperbaric oxygen therapy reduces length of hospitalization in thermal burns","volume":"10","author":"Cianci","year":"1989","journal-title":"J Burn Care Rehabil"},{"key":"2026050508221941400_ref5","doi-asserted-by":"publisher","DOI":"10.47191\/ijmscrs\/v4-i05-30","article-title":"A deep dive into the role of hyperbaric oxygen therapy in enhancing burn wound healing","volume":"4","author":"Sari","year":"2024","journal-title":"Int J. 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