{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:17:59Z","timestamp":1783412279559,"version":"3.54.6"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Jack Ruppelt Endowed Fellowship"},{"DOI":"10.13039\/100009157","name":"National Institute on Disability, Independent Living, and Rehabilitation Research","doi-asserted-by":"publisher","award":["NIDILRR grant #90DPBU0005"],"award-info":[{"award-number":["NIDILRR grant #90DPBU0005"]}],"id":[{"id":"10.13039\/100009157","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Advances in burn care have markedly improved survival after major injuries. However, survivors often experience significant physical and psychosocial sequelae. We aimed to characterize long-term health-related quality of life (HRQoL) among burn survivors to inform expected trajectories, rehabilitation needs, and common impairments. Adult burn survivors from a multicenter, longitudinal cohort study were stratified into 20.0%-49.9%, 50.0%-69.9%, and\u2009\u226570.0% total body surface area burn size groups. Patient-reported HRQoL and life satisfaction were assessed using validated outcome measures at discharge (pre-injury recall), 6, 12, 24\u00a0months, and 5\u00a0years post-injury. Standardized summary scores were derived using validated bridges. Mixed-effects linear regression models evaluated longitudinal changes and between-group differences. A total of 1113 participants were analyzed. All outcomes declined early after injury but improved progressively thereafter. Notably, by 24\u00a0months, mental-HRQoL and life satisfaction approached pre-injury levels across all burn size groups. Physical-HRQoL deficits were greater with increasing burn size, with significant net differences relative to the 20.0%-49.9% reference group (P\u2009&amp;lt;\u2009.0001). Mental-HRQoL and life satisfaction outcomes showed minimal between-group differences overall, though individuals with the largest burns exhibited significantly better relative mental-HRQoL at 24\u00a0months (P\u2009&amp;lt;\u2009.05). Although outcomes improve over time following major burn injury, persistent physical deficits support the classification of major burns as a chronic condition. These findings characterize burn size\u2013specific recovery trajectories and demonstrate that, despite persistent physical deficits, mental health and life satisfaction can return to near pre-injury levels even after the most extensive injuries.<\/jats:p>","DOI":"10.1093\/jbcr\/irag072","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:44:48Z","timestamp":1778067888000},"page":"1009-1022","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Trajectories of Health-Related Quality of Life and Life Satisfaction after Major Burn Injury: A Multicenter Cohort Study"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4237-4177","authenticated-orcid":false,"given":"Joseph","family":"Grobowski","sequence":"first","affiliation":[{"name":"UW Medicine Regional Burn Center, Department of Surgery, University of Washington , Seattle, WA 98104 ,","place":["United 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Washington , Seattle, WA 98104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hodapp","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, University of Washington , Seattle, WA 98104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1800-5849","authenticated-orcid":false,"given":"Lewis E","family":"Kazis","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital , Charlestown, MA 02129 ,","place":["United States"]},{"name":"Department of Physical Medicine and Rehabilitation, Harvard Medical School , Boston, MA 02115, \u00a0","place":["United States"]},{"name":"Department of Health Law, Policy and Management, Boston University School of Public Health , Boston, MA 02118 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell B","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC , LA 90033, California ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2729-3328","authenticated-orcid":false,"given":"Karen","family":"Kowalske","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, UT Southwestern Medical School , Dallas, TX 75390 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0373-972X","authenticated-orcid":false,"given":"Shelley A","family":"Wiechman","sequence":"additional","affiliation":[{"name":"UW Medicine Regional Burn Center, Department of Surgery, University of Washington , Seattle, WA 98104 ,","place":["United 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Tyson School of Medicine , Pasadena, CA 91101 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"UW Medicine Regional Burn Center, Department of Surgery, University of Washington , Seattle, WA 98104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1438-7483","authenticated-orcid":false,"given":"Gretchen J","family":"Carrougher","sequence":"additional","affiliation":[{"name":"UW Medicine Regional Burn Center, Department of Surgery, University of Washington , Seattle, WA 98104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam","family":"Pham","sequence":"additional","affiliation":[{"name":"UW Medicine Regional Burn Center, Department of Surgery, University of Washington , Seattle, WA 98104 ,","place":["United 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