{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:12:16Z","timestamp":1788873136798,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inhalation injury remains a major contributor to morbidity and mortality in critically ill burn patients, although its hemodynamic impact during early resuscitation is incompletely understood. Patients with inhalation injury could exhibit distinct hemodynamic alterations compared with those without inhalation injury, potentially contributing to worse outcomes. We conducted a prospective, single-center observational study over four years including adult patients with major burns. Hemodynamic variables, fluid administration, and analytical biomarkers during initial resuscitation were analyzed according to inhalation injury. A total of 180 patients were included: 96 with \u226520% TBSA burned without inhalation injury and 84 with inhalation injury irrespective of TBSA, with similar severity scores. Patients with inhalation injury were older and had lower %TBSA burned. They exhibited reduced initial cardiac index (CI), higher lactate, increased stroke volume variation, greater late extravascular lung water index, and elevated NT-proBNP. Mechanical ventilation was more frequent (88% vs. 59%), with a non-significant trend toward higher mortality (28% vs. 18%, P\u2009=\u2009.10). Fluid requirements were comparable between groups. In a predefined 25%-75% TBSA subgroup, hemodynamic patterns were consistent with the overall cohort. Among patients with inhalation injury, non-survivors showed lower initial CI and higher lactate, troponin, extravascular lung water, and NT-proBNP, despite similar intrathoracic blood volume. These findings demonstrated that inhalation injury was associated with early reductions in CI, lower preload, and a delayed increase in extravascular lung water without higher fluid requirements; mortality correlated with greater cardiac dysfunction and elevated myocardial injury biomarkers during resuscitation.<\/jats:p>","DOI":"10.1093\/jbcr\/irag096","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:48:15Z","timestamp":1781178495000},"page":"1549-1557","source":"Crossref","is-referenced-by-count":0,"title":["Cardiopulmonary Hemodynamic Alterations During Early Resuscitation in Burn Patients with Inhalation Injury: Do They Impact Prognosis?"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-1375","authenticated-orcid":false,"given":"Luc\u00eda Cachafeiro","family":"Fuci\u00f1os","sequence":"first","affiliation":[{"name":"Critical Burn Unit, Department of Intensive Care Medine, Hospital Universitario La Paz, IdiPAZ , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Agrifoglio","family":"Rotaeche","sequence":"additional","affiliation":[{"name":"Critical Burn Unit, Department of Intensive Care Medine, Hospital Universitario La Paz, IdiPAZ , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Flores","family":"Cabezas","sequence":"additional","affiliation":[{"name":"Critical Burn Unit, Department of Intensive Care Medine, Hospital Universitario La Paz, IdiPAZ , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n Est\u00e9banez","family":"Montiel","sequence":"additional","affiliation":[{"name":"Critical Burn Unit, Department of Intensive Care Medine, Hospital Universitario La Paz, IdiPAZ , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Mill\u00e1n","family":"Esta\u00f1","sequence":"additional","affiliation":[{"name":"Critical Burn Unit, Department of Intensive Care Medine, Hospital Universitario La Paz, IdiPAZ , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel S\u00e1nchez","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Critical Burn Unit, Department of Intensive Care Medine, Hospital Universitario La Paz, IdiPAZ , Madrid 28046 ,","place":["Spain"]},{"name":"Department of Physiology, Universidad Aut\u00f3noma de Madrid , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"2026090808585442100_ref1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/TA.0000000000002523","article-title":"Prevalence and prognostic impact of inhalation injury among burn patients: a systematic review and 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