{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:29:45Z","timestamp":1786490985423,"version":"build-2736575974"},"reference-count":14,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Opioid use disorder complicates the management of burn injuries, particularly in achieving adequate pain control. While prior single-institution studies have evaluated associations between opioid use and burn outcomes, multi-institutional analyses of inpatient complications remain limited. Using the American Burn Association Noncommercial Burn Research Dataset, this study compares inpatient outcomes among patients with prehospital opioid-positive screening versus those with negative screening. Among 32\u2009052 patients included, 50.5% screened positive for opioids at the time of presentation. These patients were more likely to be female (P\u2009&amp;lt;\u2009.0001), more likely to possess scald injuries (P\u2009&amp;lt;\u2009.0001), and less likely to be experiencing homelessness (P\u2009&amp;lt;\u2009.0001) or to be diagnosed with inhalation injury (P\u2009&amp;lt;\u2009.005). Opioid positivity was associated with increased odds of infectious complications, such as cellulitis (OR\u2009=\u20092.7, P\u2009&amp;lt;\u2009.0001) and sepsis (OR\u2009=\u20091.41, P\u2009&amp;lt;\u2009.001). Opioid negativity, conversely, had a higher prevalence of acute respiratory distress syndrome (P\u2009&amp;lt;\u2009.0001), acute kidney injury (P\u2009&amp;lt;\u2009.0001), respiratory failure (P\u2009&amp;lt;\u2009.05), and cardiac arrest (P\u2009&amp;lt;\u2009.05). The opioid-negative population also necessitated more frequent admission to the critical care unit (P\u2009&amp;lt;\u2009.05) and demonstrated higher overall mortality (P\u2009&amp;lt;\u2009.0001). These findings highlight the vulnerability of opioid-negative patients who may have delayed presentation and more severe injuries than originally anticipated. This work underscores the need for heightened vigilance and equitable, early care for these patients to mitigate risk in this group.<\/jats:p>","DOI":"10.1093\/jbcr\/irag126","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:02:59Z","timestamp":1785585779000},"source":"Crossref","is-referenced-by-count":0,"title":["Inpatient Complications and Outcomes for Burn Patients Admitted with Opioid-Positive Drug Screens"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5175-7028","authenticated-orcid":false,"given":"Emily P","family":"Swafford","sequence":"first","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-3307","authenticated-orcid":false,"given":"Arman J","family":"Fijany","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-592X","authenticated-orcid":false,"given":"Tyler J","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-8605","authenticated-orcid":false,"given":"Punit","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5619-5546","authenticated-orcid":false,"given":"Jordan T","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ballou","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-6398","authenticated-orcid":false,"given":"Robel T","family":"Beyene","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7130-849X","authenticated-orcid":false,"given":"Stephen","family":"Gondek","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-6755","authenticated-orcid":false,"given":"Anne","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-1591","authenticated-orcid":false,"given":"Elizabeth Dale","family":"Slater","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026081118570338600_ref1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.burns.2016.08.013","article-title":"Recent trends in burn epidemiology worldwide: a systematic review","volume":"43","author":"Smolle","year":"2017","journal-title":"Burns"},{"key":"2026081118570338600_ref2","doi-asserted-by":"publisher","first-page":"A10","DOI":"10.1016\/j.burns.2004.08.004","article-title":"Pain management","volume":"30","author":"Patterson","year":"2004","journal-title":"Burns"},{"key":"2026081118570338600_ref3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/BCR.0000000000000073","article-title":"Pain and the thermally injured patient-a review of current therapies","volume":"36","author":"Retrouvey","year":"2015","journal-title":"J Burn Care Res"},{"key":"2026081118570338600_ref4","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1093\/jbcr\/iraa119","article-title":"American burn association guidelines on the management of acute pain in the adult burn patient: a review of the literature, a compilation of expert opinion, and next steps","volume":"41","author":"Romanowski","year":"2020","journal-title":"J Burn Care Res"},{"key":"2026081118570338600_ref5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.bja.2023.12.003","article-title":"Long term opioid use after burn injury: a retrospective cohort study","volume":"132","author":"Jamal","year":"2024","journal-title":"Br J Anaesth"},{"key":"2026081118570338600_ref6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2017.09.018","article-title":"Burn injury: challenges and advances in burn wound healing, infection, pain and scarring","volume":"123","author":"Wang","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"2026081118570338600_ref7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.burns.2017.10.012","article-title":"Efficacy and feasibility of opioids for burn analgesia: an evidence-based qualitative review of randomized controlled trials","volume":"44","author":"Yang","year":"2018","journal-title":"Burns"},{"key":"2026081118570338600_ref8","volume-title":"Substance Abuse and Mental Health Services Administration, in Key Substance Use and Mental Health Indicators in the United States: Results from the 2023 National Survey on Drug Use and Health (HHS Publication No. PEP24-07-021, NSDUH Series H-59)","year":"2024"},{"key":"2026081118570338600_ref9","doi-asserted-by":"publisher","volume-title":"U.S. Overdose Deaths Decrease in 2023, First Time since 2018","year":"2024","DOI":"10.15620\/cdc\/252452"},{"key":"2026081118570338600_ref10","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1186\/s12889-024-19866-z","article-title":"Beyond individual factors: A critical ethnographic account of urban residential fire risks, experiences, and responses in single-room occupancy (SRO) housing","volume":"24","author":"Liao","year":"2024","journal-title":"BMC Public Health"},{"key":"2026081118570338600_ref11","doi-asserted-by":"publisher","first-page":"e231575","DOI":"10.1001\/jamanetworkopen.2023.1575","article-title":"Association of structural fires in New York city with inequities in safe heating for immigrant communities","volume":"6","author":"Stanton","year":"2023","journal-title":"JAMA Netw Open"},{"key":"2026081118570338600_ref12","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2147\/CLEP.S358801","article-title":"Socioeconomic disparities in prehospital emergency care in a Danish tax-financed healthcare system: nationwide cohort study","volume":"14","author":"Frydenlund","year":"2022","journal-title":"Clin Epidemiol"},{"key":"2026081118570338600_ref13","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/abm\/kaac060","article-title":"Pain in people experiencing homelessness: a scoping review","volume":"57","author":"Anastas","year":"2023","journal-title":"Ann Behav Med"},{"key":"2026081118570338600_ref14","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s11136-009-9507-x","article-title":"Measuring pain in the context of homelessness","volume":"18","author":"Matter","year":"2009","journal-title":"Qual Life Res"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irag126\/70480872\/irag126.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irag126\/70480872\/irag126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:57:07Z","timestamp":1786489027000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article\/doi\/10.1093\/jbcr\/irag126\/8751142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irag126","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"article-number":"irag126"}}