{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:30:12Z","timestamp":1793802612131,"version":"4.6.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2022YFC2403100"],"award-info":[{"award-number":["2022YFC2403100"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272259"],"award-info":[{"award-number":["82272259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Burn-wound progression contributes to early deterioration of burn severity and is closely associated with oxidative stress-induced inflammation in the zone of stasis, where mitochondria play a central role in regulating inflammatory responses and tissue damage. Melatonin is known to exert antioxidant and anti-inflammatory effects and to protect organelles from injury, suggesting a potential role in mitigating ischemia-related tissue damage. In this study, a \u201ccomb\u201d scald rat model was used to investigate whether melatonin could prevent early burn-wound progression and to elucidate the underlying mechanisms. Melatonin was administered intraperitoneally at different doses immediately after injury, and wound conversion was assessed by histological analysis. Oxidative stress markers, inflammatory cytokines, and autophagy\/mitophagy-related signals were evaluated using enzyme-linked immunosorbent assay, immunostaining, quantitative real-time polymerase chain reaction, and western blotting, with additional pharmacological modulation of autophagy and mitophagy to clarify mechanistic involvement. The results showed that melatonin significantly attenuated burn-induced activation of the HMGB1-NLRP3 inflammasome and reduced inflammatory cytokine release, while also alleviating oxidative stress, as indicated by decreased malondialdehyde levels and restored superoxide dismutase and glutathione peroxidase activities. These protective effects were closely associated with preservation of mitochondrial integrity and regulation of reactive oxygen species through autophagy, particularly PINK1-PARKIN-dependent mitophagy. Importantly, the autophagy inhibitor 3-methyladenine abolished the beneficial effects of melatonin, confirming the essential role of autophagy-related pathways. Together, these findings demonstrate that melatonin prevents early burn-wound progression by promoting mitophagy-mediated mitochondrial repair and suppressing downstream inflammatory responses.<\/jats:p>","DOI":"10.1093\/jbcr\/irag132","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:17:51Z","timestamp":1786101471000},"page":"1819-1831","source":"Crossref","is-referenced-by-count":0,"title":["Melatonin Attenuates Burn-Wound Progression by Inhibiting Inflammation Via Mitophagy-Related Pathway"],"prefix":"10.1093","volume":"47","author":[{"given":"Weixue","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine , 1511 Jianghong Road, Hangzhou, Zhejiang 310000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine , 1511 Jianghong Road, Hangzhou, Zhejiang 310000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine , 1511 Jianghong Road, Hangzhou, Zhejiang 310000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Key Laboratory of the Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province , Hangzhou, Zhejiang 310009 ,","place":["China"]},{"name":"Clinical Research Center for Basic & Translational Research, Second Affiliated Hospital of Zhejiang University School of Medicine , Hangzhou, Zhejiang 310009 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-4723","authenticated-orcid":false,"given":"Songxue","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine , 1511 Jianghong Road, Hangzhou, Zhejiang 310000 ,","place":["China"]},{"name":"Department of Burns & Wound Care Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Key Laboratory of the Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province , Hangzhou, Zhejiang 310009 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026110409165520600_ref1","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1097\/bcr.0b013e3181f93571","article-title":"A review of the local pathophysiologic bases of burn wound progression","volume":"31","author":"Shupp","year":"2010","journal-title":"J Burn Care Res"},{"key":"2026110409165520600_ref2","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0305-4179(95)00153-0","article-title":"Pathophysiology of the burn wound and pharmacological treatment. The Rudi Hermans Lecture, 1995","volume":"22","author":"Arturson","year":"1996","journal-title":"Burns"},{"key":"2026110409165520600_ref3","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.burns.2012.09.018","article-title":"Assessing paediatric scald injuries using laser speckle contrast imaging","volume":"39","author":"Lindahl","year":"2013","journal-title":"Burns"},{"key":"2026110409165520600_ref4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.burns.2008.08.011","article-title":"Accuracy of early burn depth assessment by laser Doppler imaging on different days post burn","volume":"35","author":"Hoeksema","year":"2009","journal-title":"Burns"},{"key":"2026110409165520600_ref5","doi-asserted-by":"publisher","first-page":"41440","DOI":"10.1038\/srep41440","article-title":"Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis","volume":"7","author":"Fang","year":"2017","journal-title":"Sci Rep"},{"key":"2026110409165520600_ref6","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3892\/mmr.2021.12029","article-title":"ASMq protects against early burn wound progression in rats by alleviating oxidative stress and secondary mitochondria-associated apoptosis via the Erk\/p90RSK\/Bad pathway","volume":"23","author":"Zhou","year":"2021","journal-title":"Mol Med Rep"},{"key":"2026110409165520600_ref7","doi-asserted-by":"publisher","first-page":"e0124897","DOI":"10.1371\/journal.pone.0124897","article-title":"Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats","volume":"10","author":"Guo","year":"2015","journal-title":"PLoS One"},{"key":"2026110409165520600_ref8","doi-asserted-by":"publisher","first-page":"119095","DOI":"10.1016\/j.lfs.2021.119095","article-title":"Locally activated mitophagy contributes to a \u201cbuilt-in\u201d protection against early burn-wound progression in rats","volume":"276","author":"Guo","year":"2021","journal-title":"Life Sci"},{"key":"2026110409165520600_ref9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/jpi.12123","article-title":"Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress","volume":"56","author":"Katkar","year":"2014","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1600-079x.2012.00978.x","article-title":"Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model","volume":"53","author":"Wang","year":"2012","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref11","doi-asserted-by":"publisher","first-page":"e12542","DOI":"10.1111\/jpi.12542","article-title":"Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion\/mitophagy and activating the AMPK-OPA1 signaling pathways","volume":"66","author":"Zhang","year":"2019","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref12","doi-asserted-by":"publisher","first-page":"e70010","DOI":"10.1111\/jpi.70010","article-title":"OPA1 mediated fatty acid \u03b2-oxidation in hepatocyte: the novel insight for melatonin attenuated apoptosis in concanavalin A induced acute liver injury","volume":"76","author":"Chen","year":"2024","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref13","doi-asserted-by":"publisher","first-page":"379","DOI":"10.17221\/109\/2021-vetmed","article-title":"Effect of melatonin on the gastric antioxidant defence in experimental burn trauma","volume":"67","author":"Hristova","year":"2022","journal-title":"Vet Med"},{"key":"2026110409165520600_ref14","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3390\/biom10091211","article-title":"Melatonin\u2019s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease","volume":"10","author":"Chitimus","year":"2020","journal-title":"Biomolecules"},{"key":"2026110409165520600_ref15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.nrleng.2018.08.004","article-title":"Melatonin in sleep disorders","volume":"37","author":"Poza","year":"2022","journal-title":"Neurologia (Engl Ed)"},{"key":"2026110409165520600_ref16","doi-asserted-by":"publisher","first-page":"e70074","DOI":"10.1111\/jcmm.70074","article-title":"Melatonin regulates mitochondrial dynamics and mitophagy: cardiovascular protection","volume":"28","author":"Rahmani","year":"2024","journal-title":"J Cell Mol Med"},{"key":"2026110409165520600_ref17","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1111\/jcmm.14125","article-title":"Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition","volume":"23","author":"Chen","year":"2019","journal-title":"J Cell Mol Med"},{"key":"2026110409165520600_ref18","doi-asserted-by":"publisher","first-page":"114719","DOI":"10.1016\/j.ecoenv.2023.114719","article-title":"Melatonin ameliorates glyphosate- and hard water-induced renal tubular epithelial cell senescence via PINK1-Parkin-dependent mitophagy","volume":"255","author":"Zhang","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026110409165520600_ref19","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1080\/15548627.2023.2252265","article-title":"Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation","volume":"20","author":"Deng","year":"2024","journal-title":"Autophagy"},{"key":"2026110409165520600_ref20","doi-asserted-by":"publisher","first-page":"110801","DOI":"10.1016\/j.intimp.2023.110801","article-title":"Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK\/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro","volume":"124","author":"Zhou","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"2026110409165520600_ref21","doi-asserted-by":"publisher","first-page":"106072","DOI":"10.1016\/j.phrs.2022.106072","article-title":"Melatonin-based therapeutics for atherosclerotic lesions and beyond: Focusing on macrophage mitophagy","volume":"176","author":"Ajoolabady","year":"2022","journal-title":"Pharmacol Res"},{"key":"2026110409165520600_ref22","doi-asserted-by":"publisher","first-page":"e22784","DOI":"10.1096\/fj.202201523r","article-title":"Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic\u2013ischemic brain damage","volume":"37","author":"Zhang","year":"2023","journal-title":"FASEB J"},{"key":"2026110409165520600_ref23","doi-asserted-by":"publisher","first-page":"115717","DOI":"10.1016\/j.ecoenv.2023.115717","article-title":"Melatonin alleviates particulate matter-induced liver fibrosis by inhibiting ROS-mediated mitophagy and inflammation via Nrf2 activation","volume":"268","author":"Zhu","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026110409165520600_ref24","doi-asserted-by":"publisher","first-page":"e70014","DOI":"10.1111\/jpi.70014","article-title":"Parkin-TLR4-NLRP3 axis directs melatonin to alleviate atrazine-induced immune impairment in splenic macrophages","volume":"76","author":"Liu","year":"2024","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref25","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.3390\/md13042105","article-title":"Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis","volume":"13","author":"Guo","year":"2015","journal-title":"Marine Drugs"},{"key":"2026110409165520600_ref26","doi-asserted-by":"publisher","first-page":"166785","DOI":"10.1016\/j.bbadis.2023.166785","article-title":"Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats","volume":"1869","author":"Yawoot","year":"2023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2026110409165520600_ref27","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1080\/09553000802390932","article-title":"Melatonin reduces oxidative stress in the rat lens due to radiation-induced oxidative injury","volume":"84","author":"Taysi","year":"2008","journal-title":"Int J Radiat Biol"},{"key":"2026110409165520600_ref28","doi-asserted-by":"publisher","first-page":"106102","DOI":"10.1016\/j.ejps.2021.106102","article-title":"The therapeutic effect and mechanism of rapamycin combined with HO-3867 on monocrotaline-induced pulmonary hypertension in rats","volume":"170","author":"Peng","year":"2022","journal-title":"Eur J Pharm Sci"},{"key":"2026110409165520600_ref29","doi-asserted-by":"publisher","first-page":"8369704","DOI":"10.1155\/2016\/8369704","article-title":"Acanthopanax versus 3-methyladenine ameliorates sodium taurocholate-induced severe acute pancreatitis by inhibiting the autophagic pathway in rats","volume":"2016","author":"Wang","year":"2016","journal-title":"Mediat Inflamm"},{"key":"2026110409165520600_ref30","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1056\/nejmct0804451","article-title":"Excision and skin grafting of thermal burns","volume":"360","author":"Orgill","year":"2009","journal-title":"N Engl J Med"},{"key":"2026110409165520600_ref31","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.burns.2015.11.007","article-title":"Current concepts on burn wound conversion\u2014a review of recent advances in understanding the secondary progressions of burns","volume":"42","author":"Salibian","year":"2016","journal-title":"Burns"},{"key":"2026110409165520600_ref32","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1002\/bjs.18004016413","article-title":"The diagnosis of the depth of burning","volume":"40","author":"Jackson","year":"1953","journal-title":"Br J Surg"},{"key":"2026110409165520600_ref33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/01.sap.0000252065.90759.e6","article-title":"The pathogenesis of burn wound conversion","volume":"59","author":"Singh","year":"2007","journal-title":"Ann Plast Surg"},{"key":"2026110409165520600_ref34","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.burns.2011.08.008","article-title":"Cerium nitrate treatment prevents progressive tissue necrosis in the zone of stasis following burn","volume":"38","author":"Eski","year":"2012","journal-title":"Burns"},{"key":"2026110409165520600_ref35","doi-asserted-by":"publisher","first-page":"8643","DOI":"10.3390\/ijms22168643","article-title":"Clostridium collagenase impact on zone of stasis stabilization and transition to healthy tissue in burns","volume":"22","author":"Frederick","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026110409165520600_ref36","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1600-079x.2007.00541.x","article-title":"Melatonin accelerates the process of wound repair in full-thickness incisional wounds","volume":"44","author":"Pugazhenthi","year":"2008","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref37","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref38","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuchi.2015.03.002","article-title":"Melatonin: physiological effects in humans","volume":"61","author":"Claustrat","year":"2015","journal-title":"Neurochirurgie"},{"key":"2026110409165520600_ref39","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1600-079x.2005.00256.x","article-title":"Effects of melatonin on the thermoregulatory responses to intermittent exercise","volume":"39","author":"Atkinson","year":"2005","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref40","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12300","article-title":"Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling","volume":"60","author":"Dong","year":"2016","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref41","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/sap.0b013e3181bb4b4e","article-title":"Melatonin ameliorates doxorubicin-induced skin necrosis in rats","volume":"65","author":"Kesik","year":"2010","journal-title":"Ann Plast Surg"},{"key":"2026110409165520600_ref42","doi-asserted-by":"publisher","first-page":"e12438","DOI":"10.1111\/jpi.12438","article-title":"Melatonin suppresses platelet activation and function against cardiac ischemia\/reperfusion injury via PPAR\u03b3\/FUNDC1\/mitophagy pathways","volume":"63","author":"Zhou","year":"2017","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref43","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41420-021-00729-0","article-title":"LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome","volume":"7","author":"Wang","year":"2021","journal-title":"Cell Death Discov"},{"key":"2026110409165520600_ref44","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00005-015-0366-6","article-title":"HMGB1 inhibition during zymosan-induced inflammation: the potential therapeutic action of riboflavin","volume":"64","author":"Mazur-Bialy","year":"2015","journal-title":"Arch Immunol Ther Exp"},{"key":"2026110409165520600_ref45","doi-asserted-by":"publisher","first-page":"1532590","DOI":"10.3389\/fphar.2025.1532590","article-title":"Gut microbiota and HMGB1\/NLRP3\/GSDMD inflammasome-dependent pyroptosis: mechanisms by physcion ameliorates alcoholic liver fibrosis","volume":"16","author":"Bai","year":"2025","journal-title":"Front Pharmacol"},{"key":"2026110409165520600_ref46","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.pneurobio.2016.06.006","article-title":"Mitochondrial function in hypoxic ischemic injury and influence of aging","volume":"157","author":"Ham","year":"2017","journal-title":"Prog Neurobiol"},{"key":"2026110409165520600_ref47","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2010","journal-title":"Nature"},{"key":"2026110409165520600_ref48","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1242\/jeb.132142","article-title":"A radical shift in perspective: mitochondria as regulators of reactive oxygen species","volume":"220","author":"Munro","year":"2017","journal-title":"J Exp Biol"},{"key":"2026110409165520600_ref49","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/s0305-4179(01)00088-2","article-title":"Calcium induced the damage of myocardial mitochondrial respiratory function in the early stage after severe burns","volume":"28","author":"Liang","year":"2002","journal-title":"Burns"},{"key":"2026110409165520600_ref50","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1080\/15548627.2019.1615822","article-title":"Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys","volume":"15","author":"Livingston","year":"2019","journal-title":"Autophagy"},{"key":"2026110409165520600_ref51","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"2026110409165520600_ref52","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-immunol-042617-053253","article-title":"Autophagy and inflammation","volume":"36","author":"Matsuzawa-Ishimoto","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"2026110409165520600_ref53","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis","volume":"59","author":"Fern\u00e1ndez","year":"2015","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref54","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/jpi.12354","article-title":"Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a\/silent information regulator 1 pathway","volume":"61","author":"Carloni","year":"2016","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref55","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/jpi.12086","article-title":"Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage","volume":"56","author":"Chen","year":"2013","journal-title":"J Pineal Res"},{"key":"2026110409165520600_ref56","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1126\/science.1201940","article-title":"Mitochondria and the autophagy\u2013inflammation\u2013cell death axis in organismal aging","volume":"333","author":"Green","year":"2011","journal-title":"Science"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irag132\/70634196\/irag132.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/47\/6\/1819\/70634196\/irag132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/article-pdf\/47\/6\/1819\/70634196\/irag132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:17:05Z","timestamp":1793801825000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/47\/6\/1819\/8761060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,8,13]]},"published-print":{"date-parts":[[2026,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irag132","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,8,13]]}}}