{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:24:09Z","timestamp":1787847849301,"version":"build-2784847793"},"reference-count":81,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Burn wound healing remains a major clinical challenge. This review evaluates microRNA-engineered extracellular vesicles as cell-free therapeutics and proposes a burn-oriented framework linking engineering strategies with burn-specific biological and clinical barriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A structured literature search was conducted in PubMed\/MEDLINE, Embase, Web of Science Core Collection, Scopus, Google Scholar, and the China National Knowledge Infrastructure for studies published between January 1, 2021, and July 4, 2026. Burn-focused and broader wound-healing evidence was reviewed, with relevant earlier seminal studies included when necessary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Upstream parental-cell programming, downstream vesicle modification, and biomaterial-assisted delivery may improve cargo control, targeting, retention, and therapeutic performance. However, much of the available evidence remains derived from non-burn wound models. Burn-specific translation must also address burn depth, eschar, infection, hypoxia, systemic inflammation, inhalation injury, grafting requirements, dose scaling for large burns, repeat application, storage, sterility, and compatibility with debridement and grafting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MicroRNA-engineered extracellular vesicles are a versatile platform for burn wound repair, but clinical translation remains speculative without robust large-animal, infected-burn, grafting, long-term scar, and human safety data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jbcr\/irag133","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:53:00Z","timestamp":1786535580000},"source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA-Engineered Extracellular Vesicles for Burn Wound Repair: Burn-Specific Design and Translational Perspectives"],"prefix":"10.1093","author":[{"given":"Xinrui","family":"Jin","sequence":"first","affiliation":[{"name":"Second Clinical Medical College, Anhui Medical University , No. 15 Feicui Road, Hefei, Anhui 230601 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-1575","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The Second Affiliated Hospital of Anhui Medical University , Hefei, Anhui 230601 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026082711410945600_ref1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2026082711410945600_ref2","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1097\/SLA.0000000000006270","article-title":"Burns and mental health: a matched cohort study","volume":"281","author":"Kang-Auger","year":"2025","journal-title":"Ann Surg"},{"key":"2026082711410945600_ref3","doi-asserted-by":"publisher","first-page":"3749","DOI":"10.3390\/ijms24043749","article-title":"Burns: classification, pathophysiology, and treatment: a review","volume":"24","author":"\u017bwiere\u0142\u0142o","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026082711410945600_ref4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.4252\/wjsc.v14.i5.318","article-title":"Mesenchymal stem cell-derived exosomes: a novel and potential remedy for cutaneous wound healing and regeneration","volume":"14","author":"Hu","year":"2022","journal-title":"World J Stem Cells"},{"key":"2026082711410945600_ref5","doi-asserted-by":"publisher","first-page":"384","DOI":"10.23736\/S0026-4806.20.07205-5","article-title":"Stem cell-derived exosomes for wound healing: current status and promising directions","volume":"112","author":"Vu","year":"2021","journal-title":"Minerva Med"},{"key":"2026082711410945600_ref6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41392-023-01704-0","article-title":"Clinical applications of stem cell-derived exosomes","volume":"9","author":"Tan","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026082711410945600_ref7","doi-asserted-by":"publisher","first-page":"1473789","DOI":"10.3389\/freae.2024.1473789","article-title":"MicroRNAs provide negative feedback and stability in gene regulatory network models of cell-state transitions","volume":"2","author":"Razavi-Mohseni","year":"2024","journal-title":"Front Epigenet Epigenom"},{"key":"2026082711410945600_ref8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00438-024-02183-w","article-title":"Exosomes and microRNAs: insights into their roles in thermal-induced skin injury, wound healing and scarring","volume":"299","author":"Wang","year":"2024","journal-title":"Mol Gen Genomics"},{"key":"2026082711410945600_ref9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s12015-020-09992-7","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells accelerate cutaneous wound healing by enhancing angiogenesis through delivering Angiopoietin-2","volume":"17","author":"Liu","year":"2021","journal-title":"Stem Cell Rev Rep"},{"key":"2026082711410945600_ref10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12951-022-01504-8","article-title":"Exosomes from human induced pluripotent stem cells-derived keratinocytes accelerate burn wound healing through miR-762 mediated promotion of keratinocytes and endothelial cells migration","volume":"20","author":"Bo","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"2026082711410945600_ref11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jconrel.2022.05.027","article-title":"Exosomes: large-scale production, isolation, drug loading efficiency, and biodistribution and uptake","volume":"347","author":"Kimiz-Gebologlu","year":"2022","journal-title":"J Control Release"},{"key":"2026082711410945600_ref12","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.jconrel.2020.10.020","article-title":"Challenges in the development and establishment of exosome-based drug delivery systems","volume":"329","author":"Wang","year":"2021","journal-title":"J Control Release"},{"key":"2026082711410945600_ref13","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicles"},{"key":"2026082711410945600_ref14","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1136\/bmj.328.7453.1427","article-title":"ABC of burns: pathophysiology and types of burns","volume":"328","author":"Hettiaratchy","year":"2004","journal-title":"BMJ."},{"key":"2026082711410945600_ref15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s13770-025-00741-w","article-title":"Angiogenic ability of extracellular vesicles derived from Angio-miRNA-modified mesenchymal stromal cells","volume":"22","author":"Wada","year":"2025","journal-title":"Tissue Eng Regen Med"},{"key":"2026082711410945600_ref16","doi-asserted-by":"publisher","first-page":"101359","DOI":"10.1016\/j.mtbio.2024.101359","article-title":"Multifunctional layered microneedle patches enable transdermal angiogenesis and immunomodulation for scarless healing of thermal burn injuries","volume":"29","author":"Chen","year":"2024","journal-title":"Mater Today Bio"},{"key":"2026082711410945600_ref17","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.bioactmat.2025.09.031","article-title":"Study on the mechanism of hUCMSCs-derived 3D exosome combined with HAMA microneedles in the treatment of deep second-degree burns","volume":"56","author":"Elakkawi","year":"2026","journal-title":"Bioact Mater"},{"key":"2026082711410945600_ref18","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.3969\/j.issn.1005-9202.2025.10.032","article-title":"Effect of miR-133b-overexpressing exosomes on pathogenic bacteria and wound healing in burned rats [in Chinese]","volume":"45","author":"Jing","year":"2025","journal-title":"Zhongguo Laonianxue Zazhi"},{"key":"2026082711410945600_ref19","doi-asserted-by":"publisher","first-page":"tkae018","DOI":"10.1093\/burnst\/tkae018","article-title":"Engineered nanovesicles from activated neutrophils with enriched bactericidal proteins have molecular debridement ability and promote infectious wound healing","volume":"12","author":"Jin","year":"2024","journal-title":"Burns Trauma"},{"key":"2026082711410945600_ref20","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.3390\/ph14121263","article-title":"Antimicrobial and regenerative effects of placental multipotent mesenchymal stromal cell Secretome-based chitosan gel on infected burns in rats","volume":"14","author":"Kudinov","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"2026082711410945600_ref21","doi-asserted-by":"publisher","first-page":"276","DOI":"10.18053\/jctres.08.202204.003","article-title":"Systemic anti-inflammatory effects of mesenchymal stem cells in burn: a systematic review of animal studies","volume":"8","author":"Eldaly","year":"2022","journal-title":"J Clin Transl Res"},{"key":"2026082711410945600_ref22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/ams2.17","article-title":"Immune response to traumatic injury: harmony and discordance of immune system homeostasis","volume":"1","author":"Osuka","year":"2014","journal-title":"Acute Med Surg"},{"key":"2026082711410945600_ref23","doi-asserted-by":"publisher","first-page":"123098","DOI":"10.1016\/j.carbpol.2024.123098","article-title":"Sprayable, antimicrobial and immunoregulation hydrogel loading exosomes based on oxidized sodium alginate for efficient wound healing at skin graft donor sites and health detection","volume":"351","author":"Shen","year":"2025","journal-title":"Carbohydr Polym"},{"key":"2026082711410945600_ref24","doi-asserted-by":"publisher","first-page":"138712","DOI":"10.1016\/j.ijbiomac.2024.138712","article-title":"Exosome laden sprayable thermo-sensitive polysaccharide-based hydrogel for enhanced burn wound healing","volume":"290","author":"Vipin","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026082711410945600_ref25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/1779346","article-title":"Preconditioning and engineering strategies for improving the efficacy of mesenchymal stem cell-derived exosomes in cell-free therapy","volume":"2022","author":"Chen","year":"2022","journal-title":"Stem Cells Int"},{"key":"2026082711410945600_ref26","doi-asserted-by":"publisher","first-page":"109750","DOI":"10.1016\/j.bej.2025.109750","article-title":"Three-dimensional and serum-free culture in fixed-bed bioreactor enhance exosome production by affecting the cytoskeleton through integrin \u03b21 and RAC1","volume":"220","author":"Huo","year":"2025","journal-title":"Biochem Eng J"},{"key":"2026082711410945600_ref27","doi-asserted-by":"publisher","first-page":"2500007","DOI":"10.1002\/anbr.202500007","article-title":"Enhanced exosome production in mesenchymal stem cells via extracellular matrix-incorporated 3D spheroid printing","volume":"5","author":"Heo","year":"2025","journal-title":"Adv NanoBiomed Res"},{"key":"2026082711410945600_ref28","doi-asserted-by":"publisher","first-page":"rbae035","DOI":"10.1093\/rb\/rbae035","article-title":"Enhanced burn wound healing by controlled-release 3D ADMSC-derived exosome-loaded hyaluronan hydrogel","volume":"11","author":"Zhu","year":"2024","journal-title":"Regener Biomater"},{"key":"2026082711410945600_ref29","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1186\/s12951-021-01126-6","article-title":"Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612","volume":"19","author":"Ge","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"2026082711410945600_ref30","doi-asserted-by":"publisher","first-page":"e13465","DOI":"10.1111\/1753-0407.13465","article-title":"IFN-\u03b3 enhances the therapeutic efficacy of MSCs-derived exosome via miR-126-3p in diabetic wound healing by targeting SPRED1","volume":"16","author":"Lu","year":"2024","journal-title":"J Diabetes"},{"key":"2026082711410945600_ref31","doi-asserted-by":"publisher","first-page":"1713004","DOI":"10.3389\/fimmu.2026.1713004","article-title":"Mechanisms underlying the role of TNF-\u03b1 and IL-1\u03b2 preconditioned exosomes derived from human umbilical cord mesenchymal stem cells in wound healing","volume":"17","author":"Zhou","year":"2026","journal-title":"Front Immunol"},{"key":"2026082711410945600_ref32","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s13287-020-01824-2","article-title":"Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT\/eNOS pathway","volume":"11","author":"Yu","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"2026082711410945600_ref33","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13287-025-04181-0","article-title":"MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy","volume":"16","author":"Liang","year":"2025","journal-title":"Stem Cell Res Ther"},{"key":"2026082711410945600_ref34","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1016\/j.gendis.2022.10.020","article-title":"Emerging chemical engineering of exosomes as \u201cbioscaffolds\u201d in diagnostics and therapeutics","volume":"10","author":"Wang","year":"2023","journal-title":"Genes Dis"},{"key":"2026082711410945600_ref35","doi-asserted-by":"publisher","first-page":"336","DOI":"10.2174\/1871530322666220523151713","article-title":"Engineered BMSCs-derived Exosomal miR-542-3p promotes cutaneous wound healing","volume":"23","author":"Xiong","year":"2023","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"2026082711410945600_ref36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3390\/ncrna8050071","article-title":"Combinatorial microRNA loading into extracellular vesicles for increased anti-inflammatory efficacy","volume":"8","author":"Pottash","year":"2022","journal-title":"Noncoding RNA"},{"key":"2026082711410945600_ref37","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1021\/acsami.2c20728","article-title":"An effective peptide-based platform for efficient Exosomal loading and cellular delivery of a microRNA","volume":"15","author":"Hade","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"key":"2026082711410945600_ref38","doi-asserted-by":"publisher","first-page":"e2415942","DOI":"10.1002\/advs.202415942","article-title":"A new strategy to functionalize exosomes via enzymatic engineering of surface glycans and its application to profile Exosomal glycans and endocytosis","volume":"12","author":"Kundu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026082711410945600_ref39","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12951-025-03337-7","article-title":"Exosome-like vesicles encapsulated with specific microRNAs accelerate burn wound healing and ameliorate scarring","volume":"23","author":"Lei","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"2026082711410945600_ref40","doi-asserted-by":"publisher","first-page":"e06162","DOI":"10.1002\/smll.202506162","article-title":"Microfluidic generation of exosome-mimetic nanoparticles for scalable production and enhanced therapeutic efficacy","volume":"21","author":"Kim","year":"2025","journal-title":"Small."},{"key":"2026082711410945600_ref41","doi-asserted-by":"publisher","first-page":"126715","DOI":"10.1016\/j.ijpharm.2026.126715","article-title":"Fully synthetic, nature-inspired exosome-mimetics for melanoma therapy","volume":"693","author":"Ozturk","year":"2026","journal-title":"Int J Pharm"},{"key":"2026082711410945600_ref42","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1080\/10717544.2021.2023699","article-title":"Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis","volume":"29","author":"Yan","year":"2022","journal-title":"Drug Deliv"},{"key":"2026082711410945600_ref43","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1002\/jcb.29657","article-title":"Exosome mediated transfer of miRNA-140 promotes enhanced chondrogenic differentiation of bone marrow stem cells for enhanced cartilage repair and regeneration","volume":"121","author":"Won Lee","year":"2020","journal-title":"J Cell Biochem"},{"key":"2026082711410945600_ref44","doi-asserted-by":"publisher","first-page":"e12111","DOI":"10.1002\/jev2.12111","article-title":"Exogenous loading of miRNAs into small extracellular vesicles","volume":"10","author":"de Abreu","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"2026082711410945600_ref45","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.ymthe.2019.12.007","article-title":"Enhanced loading of functional miRNA cargo via pH gradient modification of extracellular vesicles","volume":"28","author":"Jeyaram","year":"2020","journal-title":"Mol Ther"},{"key":"2026082711410945600_ref46","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1186\/s12967-025-07077-y","article-title":"Extracellular vesicles for targeted drug delivery: advances in surface modification strategies and therapeutic applications","volume":"23","author":"Hu","year":"2025","journal-title":"J Transl Med"},{"key":"2026082711410945600_ref47","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.jconrel.2020.07.042","article-title":"Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: strategies and significance","volume":"326","author":"Salunkhe","year":"2020","journal-title":"J Control Release"},{"key":"2026082711410945600_ref48","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.jconrel.2023.03.013","article-title":"Engineering exosome-based biomimetic nanovehicles for wound healing","volume":"356","author":"Joorabloo","year":"2023","journal-title":"J Control Release"},{"key":"2026082711410945600_ref49","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s44222-025-00277-7","article-title":"Extracellular vesicles for the delivery of gene therapy","volume":"3","author":"Di Ianni","year":"2025","journal-title":"Nat Rev Bioeng"},{"key":"2026082711410945600_ref50","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s13287-024-04005-7","article-title":"Different storage and freezing protocols for extracellular vesicles: a systematic review","volume":"15","author":"Ahmadian","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"2026082711410945600_ref51","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3390\/pharmaceutics14030653","article-title":"Chemically modified extracellular vesicles and applications in radiolabeling and drug delivery","volume":"14","author":"N\u2019Diaye","year":"2022","journal-title":"Pharmaceutics."},{"key":"2026082711410945600_ref52","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41578-024-00693-y","article-title":"Wound management materials and technologies from bench to bedside and beyond","volume":"9","author":"Wang","year":"2024","journal-title":"Nat Rev Mater"},{"key":"2026082711410945600_ref53","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.2147\/IJN.S291956","article-title":"A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes","volume":"16","author":"Gurunathan","year":"2021","journal-title":"Int J Nanomedicine"},{"key":"2026082711410945600_ref54","doi-asserted-by":"publisher","first-page":"115087","DOI":"10.1016\/j.biopha.2023.115087","article-title":"A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy","volume":"165","author":"Li","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2026082711410945600_ref55","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1007\/s10787-025-02084-3","article-title":"Cell-free therapeutics for non-healing wounds: Role of MSC-derived exosomes in macrophage polarization, angiogenesis, and fibroblast-mediated ECM remodeling-bridging preclinical insights to clinical translation","volume":"34","author":"AlAdwan","year":"2026","journal-title":"Inflammopharmacology."},{"key":"2026082711410945600_ref56","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41392-022-01263-w","article-title":"MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026082711410945600_ref57","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.bioactmat.2025.06.013","article-title":"AntagomiR-192-5p-engineered exosomes encapsulated in MXene-modified GelMA hydrogel facilitated epithelization of burn wounds by targeting OLFM4","volume":"52","author":"Liu","year":"2025","journal-title":"Bioact Mater"},{"key":"2026082711410945600_ref58","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1038\/s41467-024-47696-5","article-title":"Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing","volume":"15","author":"Han","year":"2024","journal-title":"Nat Commun"},{"key":"2026082711410945600_ref59","doi-asserted-by":"publisher","first-page":"142271","DOI":"10.1016\/j.ijbiomac.2025.142271","article-title":"Accelerated healing of full-thickness skin wounds by multifunctional exosome-loaded scaffolds of alginate hydrogel\/PCL nanofibers with hemostatic efficacy","volume":"307","author":"Ashrafi","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"2026082711410945600_ref60","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13287-021-02697-9","article-title":"The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review","volume":"13","author":"Bian","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"2026082711410945600_ref61","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3390\/gels8060328","article-title":"Hydrogels for exosome delivery in biomedical applications","volume":"8","author":"Xie","year":"2022","journal-title":"Gels."},{"key":"2026082711410945600_ref62","doi-asserted-by":"publisher","first-page":"4987","DOI":"10.3390\/ijms26114987","article-title":"Extracellular-matrix-mimetic hydrogels by using nanomaterials","volume":"26","author":"Kim","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026082711410945600_ref63","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/s41467-024-44968-y","article-title":"Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing","volume":"15","author":"Pranantyo","year":"2024","journal-title":"Nat Commun"},{"key":"2026082711410945600_ref64","doi-asserted-by":"publisher","first-page":"6050","DOI":"10.1038\/s41467-025-60858-3","article-title":"Microenvironment-feedback regulated hydrogels as living wound healing materials","volume":"16","author":"Cheng","year":"2025","journal-title":"Nat Commun"},{"key":"2026082711410945600_ref65","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.1038\/s41467-025-58987-w","article-title":"A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat Commun"},{"key":"2026082711410945600_ref66","doi-asserted-by":"publisher","first-page":"102931","DOI":"10.1016\/j.mtbio.2026.102931","article-title":"MicroRNA-493-5p engineered exosomes delivered via piezoelectric microneedles for epigenetic modulation of macrophages in diabetic wound healing","volume":"37","author":"Chen","year":"2026","journal-title":"Mater Today Bio"},{"key":"2026082711410945600_ref67","doi-asserted-by":"publisher","first-page":"9209","DOI":"10.3390\/ijms22179209","article-title":"miRNAs as regulators of the early local response to burn injuries","volume":"22","author":"Foessl","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026082711410945600_ref68","doi-asserted-by":"publisher","first-page":"152189","DOI":"10.1016\/j.acthis.2024.152189","article-title":"Human umbilical cord mesenchymal stem cells-derived exosomes attenuate burn-induced acute lung injury via inhibiting ferroptosis","volume":"126","author":"Li","year":"2024","journal-title":"Acta Histochem"},{"key":"2026082711410945600_ref69","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.3390\/ijms24021337","article-title":"The machinery of exosomes: biogenesis, release, and uptake","volume":"24","author":"Krylova","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026082711410945600_ref70","doi-asserted-by":"publisher","first-page":"284","DOI":"10.14348\/molcells.2022.2033","article-title":"Manufacturing therapeutic exosomes: from bench to industry","volume":"45","author":"Ahn","year":"2022","journal-title":"Mol Cells"},{"key":"2026082711410945600_ref71","doi-asserted-by":"publisher","first-page":"811971","DOI":"10.3389\/fbioe.2021.811971","article-title":"Review on strategies and technologies for exosome isolation and purification","volume":"9","author":"Chen","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"2026082711410945600_ref72","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41551-019-0485-1","article-title":"Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation","volume":"4","author":"Yang","year":"2020","journal-title":"Nat Biomed Eng"},{"key":"2026082711410945600_ref73","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41392-025-02312-w","article-title":"Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"2026082711410945600_ref74","doi-asserted-by":"publisher","first-page":"398","DOI":"10.20517\/evcna.2025.33","article-title":"Extracellular vesicles as vehicles for small non-coding RNA therapeutics: standardization challenges for clinical translation","volume":"6","author":"Luisotti","year":"2025","journal-title":"Extracell Vesicles Circ Nucleic Acids"},{"key":"2026082711410945600_ref75","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3390\/biomedicines10040869","article-title":"Characteristics of extracellular vesicles and preclinical testing considerations prior to clinical applications","volume":"10","author":"Yoo","year":"2022","journal-title":"Biomedicines."},{"key":"2026082711410945600_ref76","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1186\/s12951-023-02081-0","article-title":"Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification","volume":"21","author":"Liu","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"2026082711410945600_ref77","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12575-024-00241-6","article-title":"MicroRNA Nano-shuttles: Engineering extracellular vesicles as a cutting-edge biotechnology platform for clinical use in therapeutics","volume":"26","author":"Menjivar","year":"2024","journal-title":"Biol Proced Online"},{"key":"2026082711410945600_ref78","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1093\/jbcr\/irae049","article-title":"Pathophysiology of severe burn injuries: new therapeutic opportunities from a systems perspective","volume":"45","author":"Dobson","year":"2024","journal-title":"J Burn Care Res"},{"key":"2026082711410945600_ref79","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/SHK.0000000000001938","article-title":"Burn injury-induced extracellular vesicle production and characteristics","volume":"57","author":"Yang","year":"2022","journal-title":"Shock."},{"key":"2026082711410945600_ref80","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1080\/03639045.2025.2541789","article-title":"Prospects of engineered exosomes in clinical applications: a review","volume":"51","author":"Li","year":"2025","journal-title":"Drug Dev Ind Pharm"},{"key":"2026082711410945600_ref81","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1186\/s12967-025-06578-0","article-title":"Precision exosome engineering for enhanced wound healing and scar revision","volume":"23","author":"Liu","year":"2025","journal-title":"J Transl Med"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irag133\/70634181\/irag133.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irag133\/70634181\/irag133.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:41:15Z","timestamp":1787845275000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article\/doi\/10.1093\/jbcr\/irag133\/8761056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":81,"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irag133","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"article-number":"irag133"}}