{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:09:02Z","timestamp":1788808142619,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Technology Project of National Administration of Traditional Chinese Medicine","award":["GZY-KJS-SD-2023-071"],"award-info":[{"award-number":["GZY-KJS-SD-2023-071"]}]},{"name":"Shandong Traditional Chinese Medicine Science and Technology Project","award":["M-2023037"],"award-info":[{"award-number":["M-2023037"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH021"],"award-info":[{"award-number":["ZR2024MH021"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute kidney injury (AKI) is a common early complication in critically ill patients with burn injuries, but its risk factors remain incompletely understood. This study aimed to identify independent risk factors for early AKI in this population. A retrospective study enrolled 98 critically ill patients with burn injuries admitted to the participating medical center from January 2016 to September 2025. Patients were divided into AKI and non-AKI groups based on AKI occurrence within 3\u00a0days postinjury. Admission data (demographics, laboratory parameters, and inflammatory indices) were analyzed. Independent risk factors were identified via univariate analysis, multicollinearity diagnosis, and multivariate logistic regression; a prediction model was constructed and evaluated using receiver operating characteristic (ROC) curve analysis. The incidence of early AKI in critically ill patients with burn injuries was 28.6%. The multivariate logistic regression analysis revealed that blood urea nitrogen (BUN; odds ratio [OR]\u2009=\u20091.519; 95% CI, 1.042\u2009~\u20092.214; P\u2009=\u2009.030), cystatin C (CYS; OR\u2009=\u200912.142; 95% CI, 1.240\u2009~\u2009118.858; P\u2009=\u2009.032), and D-dimer (OR\u2009=\u20091.136; 95% CI, 1.006\u2009~\u20091.283; P\u2009=\u2009.040) levels were independent risk factors for early AKI. The prediction model equation was logit(P)\u2009=\u2009\u22129.159\u2009+\u20090.418\u2009\u00d7\u2009BUN (mmol\/L)\u2009+\u20092.497\u2009\u00d7\u2009CYS (mg\/L)\u2009+\u20090.127\u2009\u00d7\u2009D-dimer (mg\/L). The area under the ROC curve for this model was 0.887 (95% CI, 0.816\u2009~\u20090.958; P\u2009&amp;lt;\u2009.001), and the optimal cut-off value was determined by the maximum Youden index, which was 0.235. According to the prediction equation, a calculated probability P\u2009\u2265\u2009.235 indicates a high risk of early AKI. Elevated BUN, CYS, and D-dimer levels increase early AKI risk in critically ill patients with burn injuries.<\/jats:p>","DOI":"10.1093\/jbcr\/irag146","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:16:47Z","timestamp":1786965407000},"source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Risk Factors for Early Acute Kidney Injury in Critically Ill Burn Patients"],"prefix":"10.1093","author":[{"given":"Jie","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery, Shandong Provincial Hospital Afffliated to Shandong First Medical University , Jinan, Shandong 250021 ,","place":["People\u2019s Republic of China"]},{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong 250117 ,","place":["People\u2019s Republic of 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Jinan, Shandong 250117 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Shandong Provincial Hospital Afffliated to Shandong First Medical University , Jinan, Shandong 250021 ,","place":["People\u2019s Republic of China"]},{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong 250117 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Shandong Provincial Hospital Afffliated to Shandong First Medical University , Jinan, Shandong 250021 ,","place":["People\u2019s Republic of China"]},{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong 250117 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Shandong Provincial Hospital Afffliated to Shandong First Medical University , Jinan, Shandong 250021 ,","place":["People\u2019s Republic of China"]},{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong 250117 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Ci","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Shandong Provincial Hospital Afffliated to Shandong First Medical University , Jinan, Shandong 250021 ,","place":["People\u2019s Republic of China"]},{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong 250117 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongtao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, Shandong Provincial Hospital Afffliated to Shandong First Medical University , Jinan, Shandong 250021 ,","place":["People\u2019s Republic of China"]},{"name":"Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong 250117 ,","place":["People\u2019s Republic of China"]},{"name":"Department of Burn and Plastic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University , Jinan, Shandong 250021 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"2026090714562423400_ref1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13049-018-0573-3","article-title":"Factors associated with acute kidney injury in the Helsinki Burn Centre in 2006-2015","volume":"26","author":"Rakkolainen","year":"2018","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"2026090714562423400_ref2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.burnso.2023.12.004","article-title":"Acute kidney injury in burn patients: a year findings from a topmost referral burn center in West Java, Indonesia","volume":"8","author":"Hasibuan","year":"2024","journal-title":"Burns Open"},{"key":"2026090714562423400_ref3","first-page":"16","article-title":"Renal dysfunction in burns: a review","volume":"26","author":"Ibrahim","year":"2013","journal-title":"Ann Burns Fire 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