{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:09:01Z","timestamp":1788808141140,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-2-0051"],"award-info":[{"award-number":["W81XWH-20-2-0051"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Burn injuries are challenging to treat due to wound progression and long-term scarring. Mesenchymal stem cell (MSC)\u2013derived extracellular vesicles (EVs) have regenerative and immunomodulatory properties that may mitigate these complications. In this phase 1\/2a, first-in-human, open-label study, a 48-year-old man with deep second-degree burns received a single topical dose of allogeneic bone marrow MSC-derived EVs within 48 h of injury. The treated wound achieved &amp;gt; 99% closure within 1 week, with durable healing for over 1 year. Scar outcomes improved over 52 weeks, with Patient and Observer Scar Assessment Scale scores indicating early resolution of pain and pruritus and minimal residual scarring. No adverse events occurred. Laser Doppler imaging showed improved perfusion within 1 week, suggesting prevention of burn wound conversion. These findings support the potential of MSC-derived EVs to accelerate burn healing and reduce scar-related morbidity.<\/jats:p>","DOI":"10.1093\/jbcr\/irag148","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:50:35Z","timestamp":1787226635000},"source":"Crossref","is-referenced-by-count":0,"title":["Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report"],"prefix":"10.1093","author":[{"given":"Carl I","family":"Schulman","sequence":"first","affiliation":[{"name":"Department of Surgery, Ryder Trauma Center, University of Miami Leonard M. Miller School of Medicine , 1800 NW 10th Ave, Miami, FL 33136 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7021-2250","authenticated-orcid":false,"given":"Nicholas","family":"Namias","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ryder Trauma Center, University of Miami Leonard M. Miller School of Medicine , 1800 NW 10th Ave, Miami, FL 33136 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Pizano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ryder Trauma Center, University of Miami Leonard M. Miller School of Medicine , 1800 NW 10th Ave, Miami, FL 33136 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Booker T","family":"King","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Carolina , Chapel Hill, NC 27599 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley","family":"Hartman","sequence":"additional","affiliation":[{"name":"Aegle Therapeutics Corporation , 400 TradeCenter, Suite 5900, Woburn, MA 01801 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Mathews","sequence":"additional","affiliation":[{"name":"Aegle Therapeutics Corporation , 400 TradeCenter, Suite 5900, Woburn, MA 01801 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willistine","family":"Lenon","sequence":"additional","affiliation":[{"name":"Aegle Therapeutics Corporation , 400 TradeCenter, Suite 5900, Woburn, MA 01801 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Kempinski","sequence":"additional","affiliation":[{"name":"Aegle Therapeutics Corporation , 400 TradeCenter, Suite 5900, Woburn, MA 01801 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-8396","authenticated-orcid":false,"given":"Luis","family":"Rodriguez-Menocal","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine, University of Miami , 1501 NW 10th Ave, Suite 924, Miami, FL 33136 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington","family":"Guzman","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine, University of Miami , 1501 NW 10th Ave, Suite 924, Miami, FL 33136 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos V","family":"Badiavas","sequence":"additional","affiliation":[{"name":"Aegle Therapeutics Corporation , 400 TradeCenter, Suite 5900, Woburn, MA 01801 ,","place":["United States"]},{"name":"Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine, University of Miami, Interdisciplinary Stem Cell Institute , 1501 NW 10th Ave, Suite 826, Miami, FL 33136 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"2026090714562711500_ref1","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1001\/archderm.139.4.510","article-title":"Treatment of chronic wounds with bone marrow-derived cells","volume":"139","author":"Badiavas","year":"2003","journal-title":"Arch Dermatol"},{"key":"2026090714562711500_ref2","doi-asserted-by":"publisher","first-page":"8048","DOI":"10.1002\/jcb.26726","article-title":"The extracellular vesicles-derived from mesenchymal stromal cells: a new therapeutic option in regenerative medicine","volume":"119","author":"Nooshabadi","year":"2018","journal-title":"J Cell Biochem"},{"key":"2026090714562711500_ref3","doi-asserted-by":"publisher","first-page":"20595131211070783","DOI":"10.1177\/20595131211070783","article-title":"The effect of mesenchymal stem cells improves the healing of burn wounds: a phase 1 dose-escalation clinical trial","volume":"8","author":"Schulman","year":"2022","journal-title":"Scars Burn Heal"},{"key":"2026090714562711500_ref4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0305-4179(00)00118-2","article-title":"An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth","volume":"27","author":"Pape","year":"2001","journal-title":"Burns"},{"key":"2026090714562711500_ref5","doi-asserted-by":"publisher","first-page":"276","DOI":"10.4266\/acc.2019.00647","article-title":"Lund and Browder chart-modified versus original: a comparative study","volume":"34","author":"Murari","year":"2019","journal-title":"Acute Crit Care"},{"key":"2026090714562711500_ref6","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S0305-4179(01)00021-3","article-title":"Measurement of depth of burns by laser Doppler perfusion imaging","volume":"27","author":"Droog","year":"2001","journal-title":"Burns"},{"key":"2026090714562711500_ref7","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11136-022-03244-6","article-title":"Development of the Patient Scale of the Patient and Observer Scar Assessment Scale (POSAS) 3.0: a qualitative study","volume":"32","author":"Carriere","year":"2023","journal-title":"Qual Life Res"},{"key":"2026090714562711500_ref8","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jtv.2019.12.002","article-title":"Vascular perfusion: a predictive tool for thermal burn injury","volume":"29","author":"Shaw","year":"2020","journal-title":"J Tissue Viability"},{"key":"2026090714562711500_ref9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1006\/mvre.1998.2108","article-title":"Spectral analysis of the laser Doppler perfusion signal in human skin before and after exercise","volume":"56","author":"Kvernmo","year":"1998","journal-title":"Microvasc Res"},{"key":"2026090714562711500_ref10","doi-asserted-by":"publisher","first-page":"e234","DOI":"10.1371\/journal.pmed.0040234","article-title":"Hypertrophic scar formation following burns and trauma: new approaches to treatment","volume":"4","author":"Aarabi","year":"2007","journal-title":"PLoS Med"}],"container-title":["Journal of Burn Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irag148\/70725355\/irag148.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article-pdf\/doi\/10.1093\/jbcr\/irag148\/70725355\/irag148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:56:34Z","timestamp":1788807394000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/advance-article\/doi\/10.1093\/jbcr\/irag148\/8767230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1093\/jbcr\/irag148","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"article-number":"irag148"}}