{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:31:24Z","timestamp":1793802684317,"version":"4.6.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ionic Pharmaceuticals"},{"name":"SBIR program","award":["R44GM125412"],"award-info":[{"award-number":["R44GM125412"]}]},{"name":"National Center for Advancing Translational Science","award":["KL2TR001432"],"award-info":[{"award-number":["KL2TR001432"]}],"id":[{"id":"https:\/\/ror.org\/04pw6fb54","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Burn injuries disrupt the skin barrier, increasing susceptibility to infection, delaying healing, and can potentially becoming life-threatening. Wound dressings mitigate this risk by protecting the wound from environmental pathogens. This study evaluated a novel antimicrobial spray-on dressing designed to conform to irregular skin surfaces for its ability to control burn wound infection and promote wound healing. Evaluation was conducted in 2 stages. Experiment 1 used a rat scald model (n\u00a0=\u200919) inoculated with methicillin-resistant Staphylococcus aureus (MRSA) to compare the spray-on dressing\u2019s antimicrobial efficacy against silver-impregnated foam and control groups over 8\u00a0days. Experiment 2 used a porcine burn model to assess healing kinetics, skin biomechanics (elasticity, hardness), and histoarchitecture (rete ridge ratio, epidermal thickness) through Day 13. In the rat model, the spray-on dressing achieved bacterial control comparable to silver-impregnated foam; both groups demonstrated significantly lower MRSA burden compared to positive controls on Day 5 (P\u00a0&amp;lt;\u2009.01), with no evidence of systemic dissemination. In the porcine model, the spray-on dressing supported timely wound closure with re-epithelialization rates comparable to the foam dressing (97.7% vs. 92.1%, P\u00a0=\u2009.3). Skin biomechanic measurements, including tissue elasticity and stiffness, were indistinguishable from uninjured skin. Histoarchitecture analysis confirmed that the spray-on dressing facilitated a high-quality dermal-epidermal interface equivalent to the clinical standard. Overall, the novel spray-on dressing is comparable to the standard silver-impregnated foam dressing in both antimicrobial efficacy and tissue regeneration. Its superior conformability and simplified application make it a viable, efficient alternative for managing complex burn wounds in both routine and high-demand clinical settings.<\/jats:p>","DOI":"10.1093\/jbcr\/irag151","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:41:09Z","timestamp":1787398869000},"page":"1718-1727","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Spray-on Dressing Is Comparable to Silver Impregnated Foam Dressing in Controlling Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Infection and Promoting Healing"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7690-2623","authenticated-orcid":false,"given":"Lian Daniel N","family":"Manalo","sequence":"first","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail K","family":"Bruhm","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai V","family":"Myree Lindsey","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriks E","family":"Ziedins","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]},{"name":"College of Osteopathic Medicine, University of New England , Portland, ME 04005 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8332-5293","authenticated-orcid":false,"given":"Amanda M","family":"Soo Ping Chow","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5328-2203","authenticated-orcid":false,"given":"Casey S","family":"Meretta","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4394-6416","authenticated-orcid":false,"given":"Jeffrey W","family":"Shupp","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]},{"name":"Department of Surgery, Georgetown University School of Medicine , Washington, DC 20057 ,","place":["United States"]},{"name":"Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center , Washington, DC 20057 ,","place":["United States"]},{"name":"The Burn Center, Department of Surgery, MedStar Washington Hospital Center , Washington, DC 20010 ,","place":["United States"]},{"name":"Department of Plastic and Reconstructive Surgery, Georgetown University School of Medicine , Washington, DC 20057 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T","family":"Moffatt","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]},{"name":"Department of Surgery, Georgetown University School of Medicine , Washington, DC 20057 ,","place":["United States"]},{"name":"Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center , Washington, DC 20057 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-4960","authenticated-orcid":false,"given":"Bonnie C","family":"Carney","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute , Washington, DC 20010 ,","place":["United States"]},{"name":"Department of Surgery, Georgetown University School of Medicine , Washington, DC 20057 ,","place":["United States"]},{"name":"Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center , Washington, DC 20057 ,","place":["United 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