{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:52:28Z","timestamp":1791039148145,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Procedural sedation is essential for pediatric burn care, yet standardized, evidence-based regimens are lacking. This study characterizes the safety profile and pharmacological predictors of adverse events (AEs) in intensivist-led pediatric burn sedations. We conducted a retrospective cohort study of 626 procedural sedations across 208 pediatric burn patients at a single tertiary pediatric intensive care unit (PICU) from 2016 to 2025. Sedations were evaluated for medication exposure, burn severity, and clinical outcomes. A generalized estimating equation (GEE) logistic regression model, adjusting for patient demographics, burn severity, and repeated encounters, was utilized to identify independent predictors of AEs. The median patient age was 3\u00a0years, with a median total body surface area burned of 5%. The overall AE rate was 13.1%, predominantly consisting of transient respiratory events, including oxygen desaturation (9.1%) and airway obstruction (8.1%). There were zero serious AEs, such as unplanned intubations or death. Multi-drug regimens were utilized in 79.9% of encounters. In multivariable analysis, both propofol use (OR 5.10, 95% CI, 2.22-11.75, P\u2009&amp;lt;\u2009.001) and ketamine use (OR 2.64, 95% CI, 1.19-5.89, P\u2009=\u2009.018) were independent predictors of AEs, even after adjusting for baseline case complexity and burn severity. Pediatric critical care physician-led procedural sedation for pediatric burn wound care is safe, with zero serious AEs observed over a 9-year period. While propofol and ketamine are both independently associated with transient respiratory events, propofol exhibits a strict dose-dependent risk whereas ketamine\u2019s risk is dose-independent. Both require vigilance, but these predictable risk profiles allow for highly individualized, bedside risk stratification.<\/jats:p>","DOI":"10.1093\/jbcr\/irag165","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:24:36Z","timestamp":1789568676000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety and Adverse Event Profile of Procedural Sedation for Pediatric Burn Wound Care: A Single-Center Retrospective Cohort Study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0109-0912","authenticated-orcid":false,"given":"John","family":"Tumberger","sequence":"first","affiliation":[{"name":"School of Medicine, University of Kansas , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Pediatrics, Division of Pediatric Critical Care, The University of Kansas Health System , Kansas City, KS 66160 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammad","family":"Ganatra","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Pediatrics, Division of Pediatric Critical Care, The University of Kansas Health System , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Pediatrics, Division of Pediatric Critical Care, Cleveland Clinic Lerner College of Medicine , Cleveland, OH 44195 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E","family":"Burns","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas , Kansas City, KS 66160 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lauterwasser","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas , Kansas City, KS 66160 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C","family":"Slater","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Plastic Surgery, Burnett Burn Center, The University of Kansas Health System , Kansas City, KS 66160 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca P\u00e9rez","family":"Marqu\u00e8s","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Pediatrics, Division of Pediatric Critical Care, The University of Kansas Health System , Kansas City, KS 66160 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0049-0794","authenticated-orcid":false,"given":"Travis R","family":"Langner","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Pediatrics, Division of Pediatric Critical Care, The University of Kansas Health System , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Pediatrics, Division of Pediatric Critical Care, University of Missouri School of Medicine , Columbia, MO 65212 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-8184","authenticated-orcid":false,"given":"Shawn B","family":"Sood","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Kansas , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Pediatrics, Division of Pediatric Critical Care, The University of Kansas Health System , Kansas City, KS 66160 ,","place":["United States"]},{"name":"Department of Pediatrics, Division of Pediatric Critical Care, University of Missouri School of Medicine , Columbia, MO 65212 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026100309563340700_ref1","doi-asserted-by":"publisher","first-page":"107802","DOI":"10.1016\/j.burns.2025.107802","article-title":"Epidemiology of emergency department visits for burn injuries in the United States, 2014-2023","volume":"52","author":"Soulakis","year":"2026","journal-title":"Burns."},{"key":"2026100309563340700_ref2","doi-asserted-by":"publisher","first-page":"107455","DOI":"10.1016\/j.burns.2025.107455","article-title":"Nonfatal hospital-treated pediatric and adolescent burn cases in the United States: a 2019-2022 National Electronic Injury Surveillance System 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