{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:18:14Z","timestamp":1768742294073,"version":"3.49.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1093\/jbcr\/iry045","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T07:26:08Z","timestamp":1536132368000},"page":"58-71","source":"Crossref","is-referenced-by-count":28,"title":["Pigmentation Diathesis of Hypertrophic Scar: An Examination of Known Signaling Pathways to Elucidate the Molecular Pathophysiology of Injury-Related Dyschromia"],"prefix":"10.1093","volume":"40","author":[{"given":"Bonnie C","family":"Carney","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular and Cellular Biology, Georgetown University School of Medicine, Washington, District of Columbia"},{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason H","family":"Chen","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia"},{"name":"The Burn Center, Department of Surgery, MedStar Washington Hospital Center, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna N","family":"Luker","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulnaser","family":"Alkhalil","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Y","family":"Jo","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taryn E","family":"Travis","sequence":"additional","affiliation":[{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia"},{"name":"The Burn Center, Department of Surgery, MedStar Washington Hospital Center, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren T","family":"Moffatt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular and Cellular Biology, Georgetown University School of Medicine, Washington, District of Columbia"},{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia M","family":"Simbulan-Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular and Cellular Biology, Georgetown University School of Medicine, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean S","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular and Cellular Biology, Georgetown University School of Medicine, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W","family":"Shupp","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular and Cellular Biology, Georgetown University School of Medicine, Washington, District of Columbia"},{"name":"Firefighters\u2019 Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia"},{"name":"The Burn Center, Department of Surgery, MedStar Washington Hospital Center, District of Columbia"},{"name":"Department of Surgery, Georgetown University School of Medicine, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"key\n\t\t\t\t2018122003480223100_CIT0001","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/00005373-198310000-00009","article-title":"Hypertrophic burn scars: analysis of variables","volume":"23","author":"Deitch","year":"1983","journal-title":"J Trauma"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0002","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/BCR.0000000000000152","article-title":"Prevalence and prediction of prolonged pruritus after severe burns","volume":"36","author":"Gauffin","year":"2015","journal-title":"J Burn Care Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0003","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0305-4179(03)00067-6","article-title":"What is the prevalence of hypertrophic scarring following burns","volume":"29","author":"Bombaro","year":"2003","journal-title":"Burns"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0004","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bjps.2007.10.052","article-title":"The effectiveness of pressure garment therapy for the prevention of abnormal scarring after burn injury: a meta-analysis","volume":"62","author":"Anzarut","year":"2009","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0005","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.burns.2010.05.008","article-title":"Effect of different pressure magnitudes on hypertrophic scar in a Chinese population","volume":"36","author":"Candy","year":"2010","journal-title":"Burns"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0006","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.burns.2010.04.014","article-title":"12-Year within-wound study of the effectiveness of custom pressure garment therapy","volume":"36","author":"Engrav","year":"2010","journal-title":"Burns"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0007","first-page":"221","article-title":"Effects of skin rehabilitation massage therapy on pruritus, skin status, and depression in burn survivors","volume":"37","author":"Roh","year":"2007","journal-title":"Taehan Kanho Hakhoe Chi"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0008","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00004630-200021030-00002","article-title":"Postburn itching, pain, and psychological symptoms are reduced with massage therapy","volume":"21","author":"Field","year":"2000","journal-title":"J Burn Care Rehabil"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0009","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00018-009-8703-8","article-title":"Cellular mechanisms regulating human melanogenesis","volume":"66","author":"Park","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0010","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature05660","article-title":"Melanocyte biology and skin pigmentation","volume":"445","author":"Lin","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0011","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5114\/pdia.2013.33376","article-title":"Skin melanocytes: biology and development","volume":"30","author":"Cichorek","year":"2013","journal-title":"Postepy Dermatol Alergol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a017046","article-title":"Melanocytes and their diseases","volume":"4","author":"Yamaguchi","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0013","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/BCR.0000000000000224","article-title":"A primer on pigmentation","volume":"36","author":"Greenhalgh","year":"2015","journal-title":"J Burn Care Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0014","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1097\/BCR.0000000000000283","article-title":"Re: a primer on pigmentation","volume":"38","author":"Haith","year":"2015","journal-title":"J Burn Care Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0015","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jaci.2017.07.011","article-title":"Vitiligo: mechanistic insights lead to novel treatments","volume":"140","author":"Frisoli","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0016","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.8976.1","article-title":"Recent advances in understanding vitiligo","volume":"5","author":"Manga","year":"2016","journal-title":"F1000Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0017","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1097\/BCR.0000000000000097","article-title":"Biphasic presence of fibrocytes in a porcine hypertrophic scar model","volume":"36","author":"Travis","year":"2015","journal-title":"J Burn Care Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0018","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jss.2015.10.040","article-title":"Compression therapy affects collagen type balance in hypertrophic scar","volume":"201","author":"Tejiram","year":"2016","journal-title":"J Surg Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0019","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/BCR.0000000000000413","article-title":"Elastin is differentially regulated by pressure therapy in a porcine model of hypertrophic scar","volume":"38","author":"Carney","year":"2017","journal-title":"J Burn Care Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/BCR.0000000000000154","article-title":"A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar","volume":"36","author":"Travis","year":"2015","journal-title":"J Burn Care Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0021","first-page":"e29","article-title":"A translational animal model for scar compression therapy using an automated pressure delivery system","volume":"15","author":"Alkhalil","year":"2015","journal-title":"Eplasty"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0022","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/laban.164","article-title":"A fitted neoprene garment to cover dressings in swine models","volume":"42","author":"Mino","year":"2012","journal-title":"Lab Anim (NY)"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0023","doi-asserted-by":"crossref","first-page":"e90425","DOI":"10.1371\/journal.pone.0090425","article-title":"Transcriptomic analysis of the effects of a fish oil enriched diet on murine brains","volume":"9","author":"Hammamieh","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0024","first-page":"e45","article-title":"Reduction of a multidrug-resistant pathogen and associated virulence factors in a burn wound infection model: further understanding of the effectiveness of a hydroconductive dressing","volume":"14","author":"Carney","year":"2014","journal-title":"Eplasty"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1369\/0022155414562646","article-title":"Expression of human skin-specific genes defined by transcriptomics and antibody-based profiling","volume":"63","author":"Edqvist","year":"2015","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0026","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00129039-200209000-00002","article-title":"Immunohistochemical labeling of normal melanocytes","volume":"10","author":"Dean","year":"2002","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0027","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00125480-199901000-00002","article-title":"Melan-A, a new melanocytic differentiation marker","volume":"6","author":"Busam","year":"1999","journal-title":"Adv Anat Pathol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0028","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0002-9440(10)63657-7","article-title":"MLANA\/MART1 and SILV\/PMEL17\/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma","volume":"163","author":"Du","year":"2003","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0029","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cr.7310137","article-title":"Niche regulation of corneal epithelial stem cells at the limbus","volume":"17","author":"Li","year":"2007","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0030","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.cell.2006.12.045","article-title":"Central role of p53 in the suntan response and pathologic hyperpigmentation","volume":"128","author":"Cui","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0031","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1073\/pnas.93.3.1087","article-title":"DNA damage enhances melanogenesis","volume":"93","author":"Eller","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0032","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1210\/en.2007-0017","article-title":"Regulation of central melanocortin signaling by interleukin-1 beta","volume":"148","author":"Scarlett","year":"2007","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0033","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/1523-1747.ep12345496","article-title":"Proopiomelanocortin gene product regulation in keratinocytes","volume":"106","author":"Wintzen","year":"1996","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0034","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/jdv.12051","article-title":"4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation","volume":"27","author":"Kolbe","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0035","first-page":"1482","article-title":"Transforming growth factor-beta1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation","volume":"36","author":"Kim","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0036","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1046\/j.1523-1747.2001.01290.x","article-title":"The paracrine role of stem cell factor\/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation","volume":"116","author":"Hachiya","year":"2001","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0037","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/php.12400","article-title":"Nobiletin, a polymethoxy flavonoid, reduced endothelin-1 plus SCF-induced pigmentation in human melanocytes","volume":"91","author":"Kim","year":"2015","journal-title":"Photochem Photobiol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0038","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1111\/bph.13134","article-title":"cAMP-dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide","volume":"172","author":"Shin","year":"2015","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0039","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1021\/np400129z","article-title":"Caffeic acid phenethyl ester inhibits alpha-melanocyte stimulating hormone-induced melanin synthesis through suppressing transactivation activity of microphthalmia-associated transcription factor","volume":"76","author":"Lee","year":"2013","journal-title":"J Nat Prod"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0040","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejphar.2015.11.025","article-title":"N-Nicotinoyl dopamine inhibits skin pigmentation by suppressing of melanosome transfer","volume":"769","author":"Kim","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t2018122003480223100_CIT0041","doi-asserted-by":"crossref","first-page":"e1642","DOI":"10.1097\/GOX.0000000000001642","article-title":"Treatment strategies for hypopigmentation in the context of burn hypertrophic scars","volume":"6","author":"Carney","year":"2018","journal-title":"Plast Reconstr Surg Glob Open"}],"container-title":["Journal of Burn Care & Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jbcr\/article-pdf\/40\/1\/58\/27205542\/iry045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T17:10:14Z","timestamp":1571850614000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/40\/1\/58\/5090829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,9,5]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/iry045","relation":{},"ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,9,5]]}}}