{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:49:43Z","timestamp":1776149383083,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Marjolin\u2019s ulcer is a type of skin cancer that generated from chronic nonhealing trauma. For years, its pathogenesis mechanisms remain unclear. Regarding this situation, the authors retrospectively analyze the patients admitted to their department from 2005 to 2019 to present several representative cases and examine the expression patterns of survivin and its role in this process. Among these patients, the latent period ranges from 2 to 25 years, with 8.43 years in average. There is no notable relationship between the latent period and age (P = .643 &amp;gt; .05). Therefore, Marjolijn\u2019s ulcer arises from extremities and joints more often compared with other parts (P &amp;lt; .05). The expression ratio of survivin in Marjolin\u2019s ulcer is significantly higher than that in skin ulcer (P &amp;lt; 0.05). And the expression ratio of survivin in patients diagnosed with Marjolin\u2019s ulcer is also correlated with lymphatic metastasis (P &amp;lt; .05). Frequent follow-ups and prompt diagnosis and management are necessary as the prognosis is poor for patients with metastasis. Survivin may be a potential target for future development of target therapy in order to maximize the efficacy and improve the quality of life for patients suffering from Marjolin\u2019s ulcer.<\/jats:p>","DOI":"10.1093\/jbcr\/irz194","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T07:40:24Z","timestamp":1574062824000},"page":"560-567","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Features and Expression Patterns for Burn Patients Developed Marjolin Ulcer"],"prefix":"10.1093","volume":"41","author":[{"given":"Dongyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Genetics and Medical Genetics, College of Agricultural and Life Science, University of Wisconsin \u2013 Madison"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenghao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery, People\u2019s Hospital of Linyi, Shandong, P.R. 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