{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:22:02Z","timestamp":1778826122999,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Memorial Sloan Kettering Cancer Center Support Grant\/Core","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess breast imaging findings, biopsy rates, and malignancy rates in areas of palpable concern in women at high risk for breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An IRB\u2013approved retrospective review of a tertiary cancer center\u2019s breast imaging database was performed. Breast imaging and electronic medical records of high-risk women with palpable findings detected on self- or clinical breast examination from January 1, 2010, to January 1, 2016, were reviewed. Descriptive statistical analyses were conducted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Imaging correlates for 322 palpable findings in 238 high-risk women included 55\/203 (27.1%) on mammography, 183\/302 (60.6%) on US, and 20\/47 (42.6%) on MRI. Biopsies were performed for 104\/322 (32.3%) palpable findings: 95\/104 (91.3%) under imaging guidance and 9\/104 (8.7%) under palpation after negative imaging. Of 322 palpable findings, 16 (5.0%) were malignant in 16\/238 (6.7%) women, yielding a positive predictive value of biopsy of 16.8% (95% CI: 9.2%\u201324%). Women diagnosed with cancer had 16\/16 (100%) sonographic, 9\/14 (64.3%) mammographic, and 7\/7 (100%) MRI correlates. Cancer histopathology included 12 invasive ductal carcinomas, 1 ductal carcinoma in situ, 1 invasive lobular carcinoma, 1 malignant phyllodes tumor, and 1 metastatic carcinoid tumor. Over two years of follow-up imaging in 183\/238 (76.9%) women were reviewed; 7\/183 (3.8%) were diagnosed with breast cancer at least one year after presenting with a palpable concern in a different location.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>High-risk women with palpable findings exhibit a 6.7% malignancy rate, indicating the value of imaging workup in this population. In our cohort, imaging demonstrated a high negative predictive value.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jbi\/wbaa105","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T12:49:55Z","timestamp":1609159795000},"page":"190-195","source":"Crossref","is-referenced-by-count":3,"title":["Palpable Breast Findings in High-risk Patients: Are Self- and Clinical Breast Exams Worthwhile?"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5146-7135","authenticated-orcid":false,"given":"Leah H","family":"Portnow","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Evelyn H. Lauder Breast Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2500-6770","authenticated-orcid":false,"given":"Donna","family":"D\u2019Alessio","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Evelyn H. 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