{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:36:12Z","timestamp":1779255372046,"version":"3.51.4"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune and systemic inflammatory diseases represent a heterogeneous group of immune-mediated conditions with a wide range of clinical presentations and various affected organs. Autoimmune diseases can present in the breast as localized disease or as part of systemic involvement. Although breast involvement is uncommon, the spectrum of imaging findings can include breast masses, axillary adenopathy, calcifications, and skin changes, the appearance of which can mimic breast cancer. Common etiologies include diabetic mastopathy, systemic lupus erythematosus, scleroderma, rheumatoid arthritis, idiopathic granulomatous mastitis, sarcoidosis, and Immunoglobulin-G4 related mastopathy. This educational review will present multimodality imaging findings of breast manifestations of systemic inflammatory and autoimmune diseases and coexisting complications. It will also review how these disorders may affect breast cancer risk and breast cancer treatment options, including radiation therapy.<\/jats:p>","DOI":"10.1093\/jbi\/wbab029","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T18:14:35Z","timestamp":1622225675000},"page":"612-625","source":"Crossref","is-referenced-by-count":10,"title":["\u201cWhat Do You Mean It\u2019s Not Cancer?\u201d A Review of Autoimmune and Systemic Inflammatory Diseases Involving the Breast"],"prefix":"10.1093","volume":"3","author":[{"given":"Narisara","family":"Limninart","sequence":"first","affiliation":[{"name":"King Chulalongkorn Memorial Hospital, Department of Radiology , Bangkok , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-3974","authenticated-orcid":false,"given":"Jennifer A","family":"Harvey","sequence":"additional","affiliation":[{"name":"University of Rochester, Department of Medicine Imaging Sciences , Rochester, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4895-3893","authenticated-orcid":false,"given":"Katherine J","family":"Schultz","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital, Department of Pediatric Rheumatology , Cincinnati, OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M","family":"Mills","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Pathology , Charlottesville, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Margaret B","family":"Noland","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Dermatology , Charlottesville, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke T","family":"Schroen","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Surgery , Charlottesville, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie M","family":"Rochman","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Radiology and Medical Imaging , Charlottesville, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"issue":"4","key":"2023032811514319800_","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1148\/rg.314105205","article-title":"Mammographic signs of systemic disease","volume":"31","author":"Cao","year":"2011","journal-title":"Radiographics"},{"key":"2023032811514319800_","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/IJWH.S27624","article-title":"Breast manifestations of systemic diseases","volume":"4","author":"Dilaveri","year":"2012","journal-title":"Int J Womens Health"},{"issue":"5","key":"2023032811514319800_","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1590\/0100-3984.2016.0125","article-title":"Radiological findings of breast involvement in benign and malignant systemic diseases","volume":"51","author":"Matsumoto","year":"2018","journal-title":"Radiol Bras"},{"issue":"5","key":"2023032811514319800_","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2217\/WHE.12.45","article-title":"Characteristics of systemic diseases in the breast: clinical, imaging and pathologic features","volume":"8","author":"Masood","year":"2012","journal-title":"Womens Health (Lond)"},{"issue":"4","key":"2023032811514319800_","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1309\/K5HM-9603-PQ5T-KY3F","article-title":"Diabetic mastopathy. 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