{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:38:44Z","timestamp":1740181124962,"version":"3.37.3"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine prevalence and frequency of malignancy among bone lesions detected on breast MRI and to identify clinical and imaging features associated with bone metastases from breast cancer (BC), as bone lesions are suboptimally evaluated on breast imaging protocols and can present a diagnostic challenge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This IRB-approved retrospective review of breast MRIs performed from June 2009 to June 2018 identified patients with bone lesions. Demographic, clinical, and MRI features were reviewed. Clinical outcome of bone lesions was determined based on pathology and\/or additional diagnostic imaging. All benign lesions had\u2005\u22652 years of imaging follow-up. Statistics were computed using Fisher exact and Wilcoxon rank sum tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among all patients with breast MRI, 1.2% (340\/29\u2005461) had bone lesions. Of these, 224 were confirmed benign or metastatic BC by pathology or imaging follow-up, with 70.1% (157\/224) benign and 29.9% (67\/224) metastatic. Bone metastases were associated with BC history (P\u2005&amp;lt;\u20050.001), with metastases occurring in 58.2% (53\/91) of patients with current BC, 17.9% (14\/78) patients with prior BC, and 0.0% (0\/55) without BC. Bone metastases were associated with invasive and advanced stage BC and, on MRI, with location in sternum, ribs, or clavicles, larger size, multiplicity, and T1 hypointensity (all P\u2005&amp;lt;\u20050.01 in tests of overall association).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Of clinically confirmed breast MRI\u2013detected bone lesions, 30% were bone metastases; all were detected in patients with current or prior BC. Metastases were associated with advanced stage, invasive carcinoma, larger lesion size, multiplicity, low T1 signal, and non-spine location.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jbi\/wbac053","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T13:28:14Z","timestamp":1661779694000},"page":"600-611","source":"Crossref","is-referenced-by-count":1,"title":["Bone Lesions Detected on Breast MRI: Clinical Outcomes and Features Associated With Metastatic Breast Cancer"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-4046","authenticated-orcid":false,"given":"Marina J","family":"Corines","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Department of Radiology , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Coffey","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Department of Radiology , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eda","family":"Dou","sequence":"additional","affiliation":[{"name":"University of California San Francisco, Department of Radiology and Biomedical Imaging , San Francisco, CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Lobaugh","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-8403","authenticated-orcid":false,"given":"Junting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinchun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Department of Radiology , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Feigin","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Department of Radiology , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"issue":"4","key":"2022121109264602700_CIT0001","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2214\/ajr.183.4.1831149","article-title":"Sensitivity of MRI versus mammography for detecting foci of multifocal, multicentric breast cancer in fatty and dense breasts using the whole-breast pathologic examination as a gold standard","volume":"183","author":"Sardanelli","year":"2004","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"2022121109264602700_CIT0002","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1001\/jamainternmed.2013.11963","article-title":"Patterns of breast magnetic resonance imaging use in community practice","volume":"174","author":"Wernli","year":"2014","journal-title":"JAMA Intern Med"},{"issue":"1","key":"2022121109264602700_CIT0003","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1001\/jamainternmed.2013.11958","article-title":"Rapid increase in breast magnetic resonance imaging use: trends from 2000 to 2011","volume":"174","author":"Stout","year":"2014","journal-title":"JAMA Intern Med"},{"issue":"3","key":"2022121109264602700_CIT0004","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.mric.2013.04.012","article-title":"Breast MR imaging for extent of disease assessment in patients with newly diagnosed breast cancer","volume":"21","author":"Brasic","year":"2013","journal-title":"Magn Reson Imaging Clin N Am"},{"issue":"9805","key":"2022121109264602700_CIT0005","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/S0140-6736(11)61350-0","article-title":"MRI for breast cancer screening, diagnosis, and treatment","volume":"378","author":"Morrow","year":"2011","journal-title":"Lancet"},{"issue":"1","key":"2022121109264602700_CIT0006","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1148\/radiol.14141539","article-title":"Extramammary findings on breast MR examinations: frequency, clinical relevance, and patient outcomes","volume":"276","author":"Niell","year":"2015","journal-title":"Radiology"},{"issue":"5","key":"2022121109264602700_CIT0007","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1056\/NEJMoa031759","article-title":"Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition","volume":"351","author":"Kriege","year":"2004","journal-title":"N Engl J Med"},{"key":"2022121109264602700_CIT0008","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12957-016-0865-x","article-title":"Extramammary findings on breast MRI: prevalence and imaging characteristics favoring malignancy detection: a retrospective analysis","volume":"14","author":"Yang","year":"2016","journal-title":"World J Surg Oncol"},{"issue":"11","key":"2022121109264602700_CIT0009","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1007\/s00330-011-2183-6","article-title":"Extra-mammary findings in breast MRI","volume":"21","author":"Rinaldi","year":"2011","journal-title":"Eur Radiol"},{"issue":"6","key":"2022121109264602700_CIT0010","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.ejrad.2014.02.022","article-title":"Let\u2019s go out of the breast: prevalence of extra-mammary findings and their characterization on breast MRI","volume":"83","author":"Moschetta","year":"2014","journal-title":"Eur J Radiol"},{"issue":"5","key":"2022121109264602700_CIT0011","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.clbc.2015.08.003","article-title":"Frequency and clinical significance of extramammary findings on breast magnetic resonance imaging","volume":"16","author":"Phadke","year":"2016","journal-title":"Clin Breast Cancer"},{"issue":"5","key":"2022121109264602700_CIT0012","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.crad.2015.01.003","article-title":"Incidental extra-mammary findings in breast MRI","volume":"70","author":"Alduk","year":"2015","journal-title":"Clin Radiol"},{"issue":"2","key":"2022121109264602700_CIT0013","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1055\/s-2003-37227","article-title":"[Prevalence and type of incidental extramammary findings in MRI of the breast]","volume":"175","author":"Morakkabati-Spitz","year":"2003","journal-title":"Rofo"},{"issue":"10","key":"2022121109264602700_CIT0014","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.acra.2018.11.011","article-title":"Characterization of metastatic sternal lesions on dynamic contrast-enhanced breast MRI in women with invasive breast cancer","volume":"26","author":"Lee","year":"2019","journal-title":"Acad Radiol"},{"issue":"4","key":"2022121109264602700_CIT0015","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/tbj.12416","article-title":"Detection and clinical significance of sternal lesions on breast MRI","volume":"21","author":"Schaefer","year":"2015","journal-title":"Breast J"},{"key":"2022121109264602700_CIT0016","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.clinimag.2017.06.005","article-title":"Prevalence and clinical significance of incidental extra-mammary findings in breast magnetic resonance imaging: a retrospective study of 1070 patients","volume":"45","author":"Staab","year":"2017","journal-title":"Clin Imaging"},{"issue":"2","key":"2022121109264602700_CIT0017","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1200\/JCO.1998.16.2.441","article-title":"Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17","volume":"16","author":"Fisher","year":"1998","journal-title":"J Clin Oncol"},{"issue":"10","key":"2022121109264602700_CIT0018","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1245\/s10434-011-1707-2","article-title":"Ductal carcinoma-in-situ of the breast with subsequent distant metastasis and death","volume":"18","author":"Roses","year":"2011","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"2022121109264602700_CIT0019","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF02985050","article-title":"Comparison of 18FDG-PET with 99mTc-HMDP scintigraphy for the detection of bone metastases in patients with breast cancer","volume":"19","author":"Abe","year":"2005","journal-title":"Ann Nucl Med"},{"key":"2022121109264602700_CIT0020","doi-asserted-by":"crossref","first-page":"27S27s","DOI":"10.2967\/jnumed.115.157867","article-title":"Imaging bone metastases in breast cancer: staging and response assessment","volume":"57","author":"Cook","year":"2016","journal-title":"J Nucl Med"},{"issue":"2","key":"2022121109264602700_CIT0021","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.suronc.2013.01.002","article-title":"Comparison of 18 FDG PET-CT and bone scintigraphy for detection of bone metastases in breast cancer patients. A meta-analysis","volume":"22","author":"Rong","year":"2013","journal-title":"Surg Oncol"}],"container-title":["Journal of Breast Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbi\/article-pdf\/4\/6\/600\/47774503\/wbac053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbi\/article-pdf\/4\/6\/600\/47774503\/wbac053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T09:27:00Z","timestamp":1670750820000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbi\/article\/4\/6\/600\/6678477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,8,29]]},"published-print":{"date-parts":[[2022,12,11]]}},"URL":"https:\/\/doi.org\/10.1093\/jbi\/wbac053","relation":{},"ISSN":["2631-6110","2631-6129"],"issn-type":[{"type":"print","value":"2631-6110"},{"type":"electronic","value":"2631-6129"}],"subject":[],"published-other":{"date-parts":[[2022,11,1]]},"published":{"date-parts":[[2022,8,29]]}}}