{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:53:37Z","timestamp":1780548817867,"version":"3.54.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"University of Wisconsin Carbone Cancer Center Support","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019236","name":"Department of Radiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008028","name":"University of Wisconsin School of Medicine and Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Early detection of breast cancer through screening mammography saves lives. However, the sensitivity of mammography for breast cancer detection is reduced in women with dense breast tissue. Imaging modalities for supplemental breast cancer screening include MRI, whole breast US, contrast-enhanced mammography, and molecular breast imaging (MBI). Molecular breast imaging with 99mTc-sestamibi is a functional imaging test to identify metabolically active areas in the breast with positioning analogous to mammography. Since 2011, there have been six large, published studies of screening MBI as a supplement to mammography involving over 6000 women from four different institutions. A multicenter, prospective clinical trial of 3000 women comparing breast cancer detection using screening digital breast tomosynthesis alone or in combination with MBI recently completed enrollment. This review focuses on the current evidence of MBI use for supplemental breast cancer screening, the strengths and limitations of MBI, and recent technological advances.<\/jats:p>","DOI":"10.1093\/jbi\/wbad011","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T11:40:57Z","timestamp":1677930057000},"page":"240-247","source":"Crossref","is-referenced-by-count":9,"title":["Molecular Breast Imaging in the Screening Setting"],"prefix":"10.1093","volume":"5","author":[{"given":"Katherine A","family":"Smith","sequence":"first","affiliation":[{"name":"Mayo Clinic, Department of Radiology , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie N","family":"Hunt","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Department of Radiology , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaiane M","family":"Rauch","sequence":"additional","affiliation":[{"name":"The University of 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