{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:49:16Z","timestamp":1742381356674,"version":"3.37.3"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Due to the superficial location, suspicious findings of the nipple-areolar complex (NAC) are not amenable to stereotactic or MRI-guided sampling and have historically necessitated surgical biopsy or skin-punch biopsy. There are limited reports of US-guided core biopsy of the nipple (US-CBN).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We report our nearly 3-year pilot experience with US-CBN at an academic breast imaging center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An institutional review board\u2013exempt and HIPAA-compliant retrospective review was performed. We assessed patient demographics, breast imaging characteristics, procedural data, pathology, and outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Nine female patients aged 27 to 64 underwent US-CBN from January 2021 to October 2023. Initial imaging abnormalities included abnormal MRI enhancement, mammographic calcifications, and sonographic masses. After initial or second-look US, all imaging findings had sonographic correlates for biopsy specimens, the majority of which were sonographic masses (8\/9). US-CBN was performed by 6 breast radiologists using a variety of devices. All biopsy specimen results were concordant with sonographic abnormalities, although 1 was considered discordant from the initial abnormality seen on MRI. There were no complications, and discomfort during the procedure was well-treated. Two patients (22%, 2\/9) were diagnosed with malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This pilot study demonstrated that US-CBN can be performed by a breast radiologist for definitive diagnosis of suspicious nipple abnormalities seen on breast imaging, avoiding surgery, and maintaining nipple integrity. In our population, 22% (2\/9) of US-CBNs revealed malignancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jbi\/wbae033","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:55:30Z","timestamp":1723074930000},"page":"485-492","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility and Accuracy of Ultrasound-Guided Core Needle Biopsy for Nipple Lesions: A Pilot Study"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-101X","authenticated-orcid":false,"given":"Sophia R","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Medrano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily F","family":"Conant","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan P","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwadamilola M","family":"Fayanju","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8872-2846","authenticated-orcid":false,"given":"Samantha P","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-816X","authenticated-orcid":false,"given":"Christine E","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"2024111913415526300_CIT0001","first-page":"7","article-title":"Breast anatomy and basic histology, physiology, and pathology","volume-title":"Breast Imaging","author":"Kopans","year":"2007","edition":"3"},{"issue":"9","key":"2024111913415526300_CIT0002","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/cncr.20559","article-title":"Anatomy of the nipple and breast ducts revisited","volume":"101","author":"Love","year":"2004","journal-title":"Cancer"},{"issue":"2","key":"2024111913415526300_CIT0003","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1148\/rg.292085128","article-title":"Nipple-areolar complex: normal anatomy and benign and malignant processes","volume":"29","author":"Nicholson","year":"2009","journal-title":"Radiographics"},{"volume-title":"ACR BI-RADS\u00ae Atlas, Breast Imaging Reporting and Data System","year":"2013","author":"D\u2019Orsi","key":"2024111913415526300_CIT0004"},{"issue":"7","key":"2024111913415526300_CIT0005","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/jum.15517","article-title":"Ultrasound-guided breast biopsies: basic and new techniques","volume":"40","author":"Bhatt","year":"2021","journal-title":"J Ultrasound Med"},{"issue":"25","key":"2024111913415526300_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.CDR.0000473763.48551.cc","article-title":"Imaging approach to nipple masses: what a radiologist should know","volume":"38","author":"Omofoye","year":"2015","journal-title":"Contemporary Diagnostic Radiology"},{"issue":"71","key":"2024111913415526300_CIT0007","doi-asserted-by":"crossref","first-page":"267","DOI":"10.15557\/JoU.2017.0039","article-title":"Fine-needle versus core-needle biopsy - which one to choose in preoperative assessment of focal lesions in the breasts? 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