{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:44:22Z","timestamp":1792802662060,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We compared the performance of 2 breast cancer screening approaches, automated breast US (ABUS) with same-day mammography (ABUS\/MG) and handheld US (HHUS) with same-day mammography (HHUS\/MG), in women with dense breasts to better understand the relative usefulness of ABUS and HHUS in a real-world clinical setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this institutional review board\u2013approved, retrospective observational study, we evaluated all ABUS\/MG and HHUS\/MG screening examinations performed at our institution from May 2013 to September 2021. BI-RADS categories, biopsy pathology results, and diagnostic test characteristics (eg, sensitivity, specificity) were compared between the 2 screening approaches using Fisher\u2019s exact test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1120 women with dense breasts were included in this study, with 852 undergoing ABUS\/MG and 268 undergoing HHUS\/MG. The sensitivities of ABUS\/MG and HHUS\/MG were 100% (5\/5) and 75.0% (3\/4), respectively, which was not a statistically significant difference (P\u2009\u2009=\u2009.444). The ABUS\/MG approach demonstrated a slightly higher specificity (97.4% [825\/847] vs 94.3% [249\/264]; P\u2009=\u2009.028), higher accuracy (97.4% [830\/852] vs 94.0% [252\/268]; P\u2009=\u2009.011), and lower biopsy recommendation rate (3.2% [27\/852] vs 6.7% [18\/268]; P\u2009=\u2009.019) than the HHUS\/MG approach in our patient population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings suggest that ABUS\/MG performs comparably with HHUS\/MG as a breast cancer screening approach in women with dense breasts in a real-world clinical setting, with the ABUS\/MG approach demonstrating a similar sensitivity and slightly higher specificity than the HHUS\/MG approach. Additional variables, such as patient experience and physician time, may help determine which imaging approach to employ in specific clinical settings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jbi\/wbae039","type":"journal-article","created":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:16:23Z","timestamp":1719706583000},"page":"493-501","source":"Crossref","is-referenced-by-count":4,"title":["Breast Cancer Screening With Automated Breast US and Mammography vs Handheld US and Mammography in Women With Dense Breasts in a Real-World Clinical Setting"],"prefix":"10.1093","volume":"6","author":[{"given":"Andrew J","family":"Winkelman","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Michigan Health System , Ann Arbor, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassandra","family":"Tulenko","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine , Charlottesville, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha H","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University of Virginia Health System , Charlottesville, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan V","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University of Virginia Health System , Charlottesville, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clay","family":"Ford","sequence":"additional","affiliation":[{"name":"Senior Research Data Scientist\/Statistics, University of Virginia Health System , Charlottesville, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-0610","authenticated-orcid":false,"given":"Matthew M","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Radiology 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