{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:17:01Z","timestamp":1748405821249,"version":"3.41.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the upgrade rate of exclusively MRI-detected benign papillomas in asymptomatic high-risk patients, patients with a history of cancer, or patients with known malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This IRB-approved retrospective study reviewed all breast MRI\u2013guided biopsies yielding papilloma on pathology for all asymptomatic patients undergoing breast MRI for high-risk screening, newly diagnosed breast cancer, or a personal history of breast cancer. All cases were followed by excision or 2-year imaging follow-up. The upgrade rate was determined. Fisher\u2019s exact test was used to determine the significance of associated factors, including lesion type, lesion size, and ipsilateral malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 258 MRI-guided biopsies, 117 met the inclusion criteria. A 4% (5\/117) upgrade rate was found with a 3% (4\/117) upgrade rate to ductal carcinoma in situ (DCIS) and a 1% (1\/117) upgrade rate to invasive malignancy for all identified papillomas. When evaluating all papillomas, the only associated feature identified to be statically significant for risk of upgrade was ipsilateral malignancy with a 60% (3\/5) upgrade rate with a P-value of .0057. When separately evaluating benign papillomas only by excluding those with atypia or additional high-risk lesion at biopsy, a 4% (3\/80) upgrade rate to DCIS was found. There was no upgrade to invasive malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Upgrade of MRI-detected papillomas in asymptomatic high-risk patients, patients with a history of cancer, or patients with known malignancy is 4% in this population, which suggests these lesions may warrant surgical excision.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jbi\/wbae080","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T13:20:56Z","timestamp":1734528056000},"page":"196-203","source":"Crossref","is-referenced-by-count":0,"title":["Upgrade Rate of Exclusively MRI-Detected Papillomas in Asymptomatic Patients Undergoing Screening or Extent of Disease Examinations"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-706X","authenticated-orcid":false,"given":"Kathryn Watts","family":"Zamora","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceren","family":"Yalniz","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kudratjot","family":"Brar","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Zalasin","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2496-6964","authenticated-orcid":false,"given":"Stefanie","family":"Woodard","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"author":"Bidot","key":"2025052712462618000_CIT0001"},{"issue":"1","key":"2025052712462618000_CIT0002","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1245\/s10434-012-2590-1","article-title":"Nonmalignant breast papillary lesions at core-needle biopsy: a meta-analysis of underestimation and influencing factors","volume":"20","author":"Wen","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"2025052712462618000_CIT0003","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.2214\/AJR.21.25832","article-title":"Analysis of 612 benign papillomas diagnosed at core biopsy: rate of upgrade to malignancy, factors associated with upgrade, and a proposal for selective surgical excision","volume":"217","author":"Lee","year":"2021","journal-title":"AJR Am J Roentgenol"},{"key":"2025052712462618000_CIT0004","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.clinimag.2018.04.021","article-title":"Concordant, non-atypical breast papillomas do not require surgical excision: a 10-year multi-institution study and review of the literature","volume":"51","author":"Grimm","year":"2018","journal-title":"Clin 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support for imaging surveillance","volume":"19","author":"Polat","year":"2023","journal-title":"Eur J Breast Health"},{"issue":"1","key":"2025052712462618000_CIT0012","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12957-018-1537-9","article-title":"Magnetic resonance imaging features for differentiating breast papilloma with high-risk or malignant lesions from benign papilloma: a retrospective study on 158 patients","volume":"16","author":"Wang","year":"2018","journal-title":"World J Surg Oncol"}],"container-title":["Journal of Breast 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