{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:39:04Z","timestamp":1772548744398,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF 2024-015"],"award-info":[{"award-number":["BCRF 2024-015"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012288","name":"Breast Cancer Coalition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012288","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shear Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To detail acute and delayed contrast reactions associated with contrast-enhanced mammography (CEM) in a prospective screening trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an institutional review board\u2013approved protocol from October 2019 through July 2024, women with personal history of breast cancer received up to 3 rounds of annual supplemental screening CEM. Intravenous iopamidol (370\u2005mg\/mL) was administered via automated injector. Adverse events within 1 week of contrast administration were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1651 women (mean age at entry: 63.2 years) received 3873 contrast injections (1651, 1326, and 896 in years 1, 2, and 3, respectively). Among 3873 injections, we observed 38 (0.98%) contrast reactions in 35 unique participants, including 25\/3873 (0.65%) allergic-like reactions (15\/1651 [0.91%] in year 1, 7\/1326 [0.53%] in year 2, and 3\/896 [0.33%] in year 3), 9\/3873 (0.23%) physiologic reactions, and 4\/3873 (0.10%) other reactions. Of 25 allergic-like reactions, 20 (80%) were cutaneous (hives\/rash). One participant had bronchospasm, 1 had scratchy throat, 1 had shortness of breath, 1 sneezed repeatedly, and 1 had watery eyes. Five allergic-like reactions were delayed, including hives in 4 (2 at 1 day, 1 at 2-3 days, and one 7 days later) and watery eyes in 1; 2 physiologic reactions were delayed. Two of 25 reactions were immediate, and imaging was not completed; medication was given to 15\/25 (60%). Allergic-like reactions occurred in 14\/3328 (0.42%) examinations in women with prior uneventful iodinated contrast exposure, 10\/510 (1.96%) among those na\u00efve to contrast (P &amp;lt;.001), and 1 woman with recurrent but initially unreported reaction in year 1. No allergic-like reactions were observed in 34 examinations (19 women) premedicated for prior allergic contrast reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed a low rate and usually mild severity of adverse reactions to iodinated contrast in CEM with trained staff.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jbi\/wbaf043","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:01:00Z","timestamp":1750838460000},"page":"55-65","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Acute and Delayed Contrast Reactions With Multiple Exposures to Contrast-Enhanced Mammography\u2014Experience From the TOCEM Trial"],"prefix":"10.1093","volume":"8","author":[{"given":"Lin","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Radiology, UPMC Magee-Womens Hospital , Pittsburgh, PA 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