{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:34:46Z","timestamp":1790994886330,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Screening mammography false-negative rates (FNRs) measure interval cancers (ICs) that are confounded by asymptomatic false-negative (FN) cancers detected on supplemental screening (SS) examinations. The purpose of this study was to 1) evaluate the impact of SS on FNRs for patients at higher\u2013than\u2013average risk in a robust SS program and 2) compare patient and tumor characteristics of symptomatic ICs and asymptomatic FN cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Screening mammogram audit metrics from an academic institution from July 1, 2018, to June 30, 2023, were retrospectively reviewed. A negative screening mammogram with a subsequent diagnosis of cancer within 12 months was considered an FN cancer. Patient risk, method of detection, SS utilization, and tumor characteristics were collected. Cochran-Mantel-Haenszel tests were used to analyze trends, and univariable tests were used to compare symptomatic and asymptomatic cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 106 750 screening mammograms, 624 screening-detected cancers and 119 FN cancers were identified, with a cancer detection rate of 5.8\/1000 and an FNR of 1.11\/1000. There were 53 (45%) symptomatic ICs and 66 (55%) asymptomatic FNs, with a symptomatic FNR of 0.50\/1000. Patients with symptomatic IC were more likely to have a personal history of breast cancer (P = .0289), and 74% (39\/53) were higher-than-average risk. Symptomatic ICs were larger at diagnosis (mean size 2.3\u2005cm vs 1.5 cm; P = .0293). MRI detected the majority (37\/66, 60%) of asymptomatic FNs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A robust SS program allows for the symptomatic FNR to fall below published national performance benchmarks from the Breast Cancer Surveillance Consortium. Most patients with symptomatic IC were at higher-than-average risk and underutilized SS MRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jbi\/wbaf076","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T13:10:24Z","timestamp":1763125824000},"page":"277-288","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of a Robust Supplemental Screening Program on False-Negative Rates: Time for New Benchmarks?"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-5682","authenticated-orcid":false,"given":"Ashley","family":"Huppe","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Kansas Health System , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onalisa","family":"Winblad","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kansas Health System , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kansas Health System , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camron","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kansas Health System , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-2286","authenticated-orcid":false,"given":"Molly","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kansas Health System , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-0945","authenticated-orcid":false,"given":"Lauren","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kansas Health System , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kansas Health System , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-6025","authenticated-orcid":false,"given":"Allison","family":"Aripoli","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Kansas Health System , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"2026052522514578000_wbaf076-B1","author":"Important information: final rule to amend the Mammography Quality Standards Act (MQSA)"},{"key":"2026052522514578000_wbaf076-B2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41523-017-0014-x","article-title":"The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening","volume":"3","author":"Houssami","year":"2017","journal-title":"NPJ Breast Cancer"},{"issue":"10","key":"2026052522514578000_wbaf076-B3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.7326\/M14-1465","article-title":"Breast Cancer Surveillance Consortium. 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