{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:54:05Z","timestamp":1791032045668,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF 24-028"],"award-info":[{"award-number":["BCRF 24-028"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Reconciling cutoff thresholds for short-term (5-year) and long-term (lifetime) breast cancer risk could support tailored and evidence-based approaches to supplemental screening and risk management most relevant to short-term clinical actions. This study aims to consistently classify women at increased risk and provide 5-year risk cutoff that corresponds to a 20% lifetime risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using U.S. Surveillance, Epidemiology and End Results (SEER) program population incidence data for women 40 to 74 years of age, this study reports both lifetime and 5-year population-based risk estimates controlling for competing risk and age varying breast cancer incidence. A cut point for 5-year risk equivalent to lifetime risk of 20% which triggers increased screening is generated. This computation is a weighted average incorporating age, remaining life expectancy, and population risk distribution. The primary outcome is breast cancer incidence (in situ and invasive).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A lifetime risk threshold of 20% corresponded to markedly age-dependent 5-year risk cut points, increasing from \u223c1.3% at ages 40\u201344 to \u223c10.9% at ages 70\u201374. For women 40\u201374, 20% lifetime risk corresponds to a 5-year risk cut-off of 3.16%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aligning lifetime risk of \u226520% and the 5-year breast cancer risk cutoff enhances consistency of classification of women at increased risk and clinical decision-making. Women with a \u22653.16% 5-year risk of breast cancer have risk equivalent to a lifetime risk of \u226520% on average. This can facilitate rational and evidence-based approaches to short-term and long-term risk assessment results for both risk reduction and tailored screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jbi\/wbag011","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:41:17Z","timestamp":1775216477000},"page":"523-529","source":"Crossref","is-referenced-by-count":0,"title":["A Framework for Aligning 5-Year and Lifetime Breast Cancer Risk in Women Without High-Penetrance Mutations"],"prefix":"10.1093","volume":"8","author":[{"given":"Graham A","family":"Colditz","sequence":"first","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis , St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie L","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University 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