{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:43:08Z","timestamp":1793371388333,"version":"4.5.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG067698"],"award-info":[{"award-number":["R01AG067698"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AR074570"],"award-info":[{"award-number":["R21AR074570"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21AR074570"],"award-info":[{"award-number":["R21AR074570"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21AR078650"],"award-info":[{"award-number":["R21AR078650"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR079875"],"award-info":[{"award-number":["R01AR079875"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR069619"],"award-info":[{"award-number":["P30AR069619"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016787","name":"Penn Center for Musculoskeletal Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) affects multiple tissues in the knee joint, including the synovium and intra-articular adipose tissue (IAAT) that are attached to each other. However, whether these two tissues share the same progenitor cells and hence function as a single unit in joint homeostasis and diseases is largely unknown. Single-cell transcriptomic profiling of synovium and infrapatellar fat pad (IFP), the largest IAAT, from control and OA mice revealed five mesenchymal clusters and predicted mesenchymal progenitor cells (MPCs) as the common progenitors for other cells: synovial lining fibroblasts (SLFs), myofibroblasts (MFs), and preadipocytes 1 and 2. Histologic examination of joints in reporter mice having Dpp4-CreER and Prg4-CreER that label MPCs and SLFs, respectively, demonstrated that Dpp4+ MPCs reside in the synovial sublining layer and give rise to Prg4+ SLFs and Perilipin+ adipocytes during growth and OA progression. After OA injury, both MPCs and SLFs gave rise to MFs, which remained in the thickened synovium at later stages of OA. In culture, Dpp4+ MPCs possessed mesenchymal progenitor properties, such as proliferation and multilineage differentiation. In contrast, Prg4+ SLFs did not contribute to adipocytes in IFP and Prg4+ cells barely grew in vitro. Taken together, we demonstrate that the synovium and joint fat pad are one integrated functional tissue sharing common mesenchymal progenitors and undergoing coordinated changes during OA progression.<\/jats:p>","DOI":"10.1093\/jbmr\/zjad009","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T17:02:02Z","timestamp":1704214922000},"page":"161-176","source":"Crossref","is-referenced-by-count":54,"title":["Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis"],"prefix":"10.1093","volume":"39","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"Department of Bone and Joint Surgery , Institute of Orthopedic Diseases, The First Affiliated Hospital, , Guangzhou, Guangdong 510630 , China"},{"name":"Jinan University , Institute of Orthopedic Diseases, The First Affiliated Hospital, , Guangzhou, Guangdong 510630 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0652-2075","authenticated-orcid":false,"given":"Lutian","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"Department of Orthopaedics, The First Hospital of China Medical University , Shenyang, Liaoning Province 110112 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanli","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltiadis","family":"Zgonis","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Mauck","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"Translational Musculoskeletal Research Center, Corp. Michael J Crescenz, VA Medical Center , Philadelphia PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Dyment","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"Translational Musculoskeletal Research Center, Corp. Michael J Crescenz, VA Medical Center , Philadelphia PA 19104 , United States"},{"name":"Department of Physical Medicine & Rehabilitation , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Scanzello","sequence":"additional","affiliation":[{"name":"Translational Musculoskeletal Research Center, Corp. Michael J Crescenz, VA Medical Center , Philadelphia PA 19104 , United States"},{"name":"Division of Rheumatology , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Seale","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"},{"name":"University of Pennsylvania , Perelman School of Medicine, , Philadelphia, PA 19104 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"issue":"1","key":"2024032223040070500_ref1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/art.21562","article-title":"Projections of US prevalence of arthritis and associated activity limitations","volume":"54","author":"Hootman","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"3","key":"2024032223040070500_ref2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/jcp.21258","article-title":"Osteoarthritis","volume":"213","author":"Goldring","year":"2007","journal-title":"J Cell Physiol"},{"issue":"7","key":"2024032223040070500_ref3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"2024032223040070500_ref4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrrheum.2015.135","article-title":"Strategies for the prevention of knee osteoarthritis","volume":"12","author":"Roos","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"2024032223040070500_ref5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mcna.2008.08.008","article-title":"The symptoms of osteoarthritis and the genesis of pain","volume":"93","author":"Hunter","year":"2009","journal-title":"Med Clin North Am"},{"issue":"5","key":"2024032223040070500_ref6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/ar110","article-title":"Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis","volume":"2","author":"Edwards","year":"2000","journal-title":"Arthritis Res"},{"issue":"5","key":"2024032223040070500_ref7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"2024032223040070500_ref8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"issue":"3","key":"2024032223040070500_ref9","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of joint inflammation with pain sensitization in knee osteoarthritis: the multicenter osteoarthritis study","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"2024032223040070500_ref10","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1136\/annrheumdis-2016-210478","article-title":"Knee and hip intra-articular adipose tissues (IAATs) compared with autologous subcutaneous adipose tissue: a specific phenotype for a central player in osteoarthritis","volume":"76","author":"Eymard","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"2024032223040070500_ref11","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.joca.2018.03.004","article-title":"Systemic and local adipose tissue in knee osteoarthritis","volume":"26","author":"Chang","year":"2018","journal-title":"Osteoarthr Cartil"},{"issue":"12","key":"2024032223040070500_ref12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11926-019-0868-z","article-title":"Adipokines: new therapeutic target for osteoarthritis?","volume":"21","author":"Xie","year":"2019","journal-title":"Curr Rheumatol Rep"},{"issue":"6","key":"2024032223040070500_ref13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/ar4422","article-title":"An emerging player in knee osteoarthritis: the infrapatellar fat pad","volume":"15","author":"Ioan-Facsinay","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"2024032223040070500_ref14","volume":"233","journal-title":"J Anat"},{"key":"2024032223040070500_ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/6390182","article-title":"Contribution of infrapatellar fat pad and synovial membrane to knee osteoarthritis pain","volume":"2019","author":"Belluzzi","year":"2019","journal-title":"Biomed Res Int"},{"issue":"8","key":"2024032223040070500_ref16","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/jcp.25716","article-title":"Systemic and local adipose tissue in knee osteoarthritis","volume":"232","author":"Belluzzi","year":"2017","journal-title":"J Cell Physiol"},{"issue":"6","key":"2024032223040070500_ref17","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"2024032223040070500_ref18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.aanat.2018.09.007","article-title":"Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis","volume":"221","author":"Fontanella","year":"2019","journal-title":"Ann Anat"},{"issue":"3","key":"2024032223040070500_ref19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/rheumatology\/key305","article-title":"Effusion-synovitis and infrapatellar fat pad signal intensity alteration differentiate accelerated knee osteoarthritis","volume":"58","author":"Davis","year":"2019","journal-title":"Rheumatology (Oxford)"},{"issue":"10","key":"2024032223040070500_ref20","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.joca.2018.05.015","article-title":"Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the osteoarthritis initiative","volume":"26","author":"Wang","year":"2018","journal-title":"Osteoarthr Cartil"},{"issue":"10","key":"2024032223040070500_ref21","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1136\/annrheumdis-2015-208360","article-title":"Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study","volume":"75","author":"Han","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"2024032223040070500_ref22","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1002\/jcp.26860","article-title":"Fibroblasts and mesenchymal stem cells: two sides of the same coin?","volume":"233","author":"Soundararajan","year":"2018","journal-title":"J Cell Physiol"},{"key":"2024032223040070500_ref23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exer.2015.07.009","article-title":"Myofibroblasts","volume":"142","author":"Hinz","year":"2016","journal-title":"Exp Eye Res"},{"issue":"3","key":"2024032223040070500_ref24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/ard-2021-221682","article-title":"Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution","volume":"82","author":"Collins","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"2024032223040070500_ref25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/ard-2022-222773","article-title":"Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis","volume":"82","author":"Knights","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2024032223040070500_ref26","doi-asserted-by":"crossref","first-page":"10868","DOI":"10.1038\/s41598-020-67730-y","article-title":"Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis","volume":"10","author":"Chou","year":"2020","journal-title":"Sci Rep"},{"issue":"2","key":"2024032223040070500_ref27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<145::AID-GENE14>3.0.CO;2-C","article-title":"Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice","volume":"26","author":"Ovchinnikov","year":"2000","journal-title":"Genesis"},{"key":"2024032223040070500_ref28","doi-asserted-by":"crossref","first-page":"101357","DOI":"10.1016\/j.molmet.2021.101357","article-title":"Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis","volume":"54","author":"Stefkovich","year":"2021","journal-title":"Mol Metab"},{"issue":"1","key":"2024032223040070500_ref29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ydbio.2017.04.006","article-title":"Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs","volume":"426","author":"Decker","year":"2017","journal-title":"Dev Biol"},{"issue":"6","key":"2024032223040070500_ref30","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/dvdy.21179","article-title":"Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene","volume":"236","author":"Pryce","year":"2007","journal-title":"Dev Dyn"},{"issue":"12","key":"2024032223040070500_ref31","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1002\/jbmr.4717","article-title":"Activating EGFR signaling attenuates osteoarthritis development following loading injury in mice","volume":"37","author":"Gui","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024032223040070500_ref32","doi-asserted-by":"crossref","first-page":"14015","DOI":"10.1038\/boneres.2014.15","article-title":"Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model","volume":"2","author":"Zhang","year":"2014","journal-title":"Bone Res"},{"issue":"9","key":"2024032223040070500_ref33","doi-asserted-by":"crossref","first-page":"e45517","DOI":"10.1371\/journal.pone.0045517","article-title":"Isolation and characterization of multipotential mesenchymal cells from the mouse synovium","volume":"7","author":"Futami","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"2024032223040070500_ref34","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/rheumatology\/kex487","article-title":"Comparative advantages of infrapatellar fat pad: an emerging stem cell source for regenerative medicine","volume":"57","author":"Sun","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"2024032223040070500_ref35","doi-asserted-by":"crossref","first-page":"107392","DOI":"10.1016\/j.intimp.2021.107392","article-title":"Fibroblast-like synoviocytes in rheumatoid arthritis: surface markers and phenotypes","volume":"93","author":"Wu","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"6438","key":"2024032223040070500_ref36","doi-asserted-by":"crossref","first-page":"eaav2501","DOI":"10.1126\/science.aav2501","article-title":"Identification of a mesenchymal progenitor cell hierarchy in adipose tissue","volume":"364","author":"Merrick","year":"2019","journal-title":"Science"},{"issue":"1","key":"2024032223040070500_ref37","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s42003-021-01857-0","article-title":"Creb5 establishes the competence for Prg4 expression in articular cartilage","volume":"4","author":"Zhang","year":"2021","journal-title":"Commun Biol"},{"issue":"1","key":"2024032223040070500_ref38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/dbio.2001.0559","article-title":"Studies on the role of Cux1 in regulation of the onset of joint formation in the developing limb","volume":"243","author":"Lizarraga","year":"2002","journal-title":"Dev Biol"},{"issue":"5","key":"2024032223040070500_ref39","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.biochi.2009.02.002","article-title":"The role of C\/EBPdelta in the early stages of adipogenesis","volume":"91","author":"Hishida","year":"2009","journal-title":"Biochimie"},{"issue":"3","key":"2024032223040070500_ref40","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bbrc.2015.12.035","article-title":"c-Jun regulates adipocyte differentiation via the KLF15-mediated mode","volume":"469","author":"Lee","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"2024032223040070500_ref41","doi-asserted-by":"crossref","first-page":"e114133","DOI":"10.1371\/journal.pone.0114133","article-title":"MYC is an early response regulator of human adipogenesis in adipose stem cells","volume":"9","author":"Deisenroth","year":"2014","journal-title":"PLoS One"},{"key":"2024032223040070500_ref42","first-page":"989","article-title":"Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy\u2014focus on alogliptin","volume":"7","author":"Capuano","year":"2013","journal-title":"Drug Des Devel Ther"},{"issue":"7860","key":"2024032223040070500_ref43","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-021-03549-5","article-title":"Cross-tissue organization of the fibroblast lineage","volume":"593","author":"Buechler","year":"2021","journal-title":"Nature"},{"key":"2024032223040070500_ref44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.matbio.2014.08.008","article-title":"The biology of lubricin: near frictionless joint motion","volume":"39","author":"Jay","year":"2014","journal-title":"Matrix Biol"},{"issue":"13","key":"2024032223040070500_ref45","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.227900","article-title":"The myofibroblast at a glance","volume":"133","author":"Pakshir","year":"2020","journal-title":"J Cell Sci"},{"key":"2024032223040070500_ref46","doi-asserted-by":"crossref","first-page":"684389","DOI":"10.3389\/fmed.2021.684389","article-title":"Synovial fibrosis involvement in osteoarthritis","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Med (Lausanne)"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbmr\/advance-article-pdf\/doi\/10.1093\/jbmr\/zjad009\/56771945\/zjad009.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/39\/2\/161\/57063490\/zjad009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/39\/2\/161\/57063490\/zjad009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T19:07:45Z","timestamp":1711134465000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/39\/2\/161\/7505085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,4]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1,4]]},"published-print":{"date-parts":[[2024,3,22]]}},"URL":"https:\/\/doi.org\/10.1093\/jbmr\/zjad009","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,4]]}}}