{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:14Z","timestamp":1792785974861,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Marie Sk\u0142odowska-Curie","award":["860898"],"award-info":[{"award-number":["860898"]}]},{"name":"Marie Sk\u0142odowska-Curie","award":["841316"],"award-info":[{"award-number":["841316"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["234724\/2014-5"],"award-info":[{"award-number":["234724\/2014-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR003015"],"award-info":[{"award-number":["UL1TR003015"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR003016"],"award-info":[{"award-number":["KL2TR003016"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 1 diabetes mellitus (T1DM) has been linked to increased osteocyte apoptosis, local accumulation of mineralized lacunar spaces, and microdamage suggesting an impairment of the mechanoregulation network in affected individuals. Diabetic neuropathy might exacerbate this dysfunction through direct effects on bone turnover, and indirect effects on balance, muscle strength, and gait. However, the in vivo effects of impaired bone mechanoregulation on bone remodeling in humans remain underexplored. This longitudinal cohort study assessed consenting participants with T1DM and varying degree of distal symmetric sensorimotor polyneuropathy (T1DM, n\u2009=\u200920, median age 46.5\u00a0yr, eight female) and controls (CTRL; n\u2009=\u20099, median age 59.0\u00a0yr, four female) at baseline and 4\u2013yr follow-up. Nerve conduction in participants with T1DM was tested using DPNCheck and bone remodeling was quantified with longitudinal high\u2013resolution peripheral quantitative\u2013computed tomography (HR-pQCT, 82\u00a0\u03bcm) at the standard distal sites. Local trabecular bone formation (Tb.F) and resorption (Tb.R) sites were captured by implementing 3D rigid image registration of HR-pQCT images, and the mechanical environment across the bone microarchitecture at these sites was simulated using micro\u2013finite element analysis. We calculated odds ratios to determine the likelihood of bone formation (ORF) and resorption (ORR) with increasing\/decreasing strain in percent as markers for mechanoregulation. At the distal radius, Tb.F was 47% lower and Tb.R was 59% lower in T1DM participants compared with CTRL (P\u2009&amp;lt;\u2009.05). Tb.F correlated positively with nerve conduction amplitude (R\u00a0=\u00a00.69, P\u2009&amp;lt;\u2009.05) in participants with T1DM and negatively with glycated hemoglobin (HbA1c) (R\u00a0=\u2009\u22120.45, P\u2009&amp;lt;\u2009.05). Additionally, ORF was 34% lower and ORR was 18% lower in T1DM compared with CTRL (P\u2009&amp;lt;\u2009.05). Our findings represent in vivo evidence suggesting that bone remodeling in individuals with T1DM is in a state of low responsiveness to mechanical stimuli, resulting in impaired bone formation and resorption rates; these correlate to the degree of neuropathy and level of diabetes control.<\/jats:p>","DOI":"10.1093\/jbmr\/zjad014","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T17:03:47Z","timestamp":1704215027000},"page":"85-94","source":"Crossref","is-referenced-by-count":18,"title":["Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-8143","authenticated-orcid":false,"given":"Matthias","family":"Walle","sequence":"first","affiliation":[{"name":"Institute for Biomechanics, ETH Zurich , Zurich , 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