{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:23:10Z","timestamp":1789568590220,"version":"build-2803163510"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institute of Arthritis Musculoskeletal and Skin Diseases of the National Institutes of Health","award":["R01AR061445"],"award-info":[{"award-number":["R01AR061445"]}]},{"name":"National Institute of Arthritis Musculoskeletal and Skin Diseases of the National Institutes of Health","award":["AR027065"],"award-info":[{"award-number":["AR027065"]}]},{"name":"National Heart, Lung, and Blood Institute Framingham Heart Study","award":["N01-HC-25195"],"award-info":[{"award-number":["N01-HC-25195"]}]},{"name":"National Heart, Lung, and Blood Institute Framingham Heart Study","award":["HHSN268201500001I"],"award-info":[{"award-number":["HHSN268201500001I"]}]},{"DOI":"10.13039\/100002429","name":"Amgen Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp & Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR 158975"],"award-info":[{"award-number":["CIHR 158975"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR 111103"],"award-info":[{"award-number":["CIHR 111103"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Geneva University Hospitals & Faculty of Medicine Clinical Research Centre"},{"name":"Geneva University Hospitals Private Foundation"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-07-PHYSIO-023"],"award-info":[{"award-number":["ANR-07-PHYSIO-023"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-BLAN-1137"],"award-info":[{"award-number":["ANR-10-BLAN-1137"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Abondement ANVAR","award":["E1482.042"],"award-info":[{"award-number":["E1482.042"]}]},{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","award":["50564"],"award-info":[{"award-number":["50564"]}],"id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fracture risk increases with lower areal bone mineral density (aBMD); however, aBMD-related estimate of risk may decrease with age. This may depend on technical limitations of 2-dimensional (2D) dual energy X-ray absorptiometry (DXA) which are reduced with 3D high-resolution peripheral quantitative computed tomography (HR-pQCT). Our aim was to examine whether the predictive utility of HR-pQCT measures with fracture varies with age. We analyzed associations of HR-pQCT measures at the distal radius and distal tibia with two outcomes: incident fractures and major osteoporotic fractures. We censored follow-up time at first fracture, death, last contact or 8\u00a0years after baseline. We estimated hazard ratios (HR) and 95%CI for the association between bone traits and fracture incidence across age quintiles. Among 6835 men and women (ages 40\u201396) with at least one valid baseline HR-pQCT scan who were followed prospectively for a median of 48.3\u00a0months, 681 sustained fractures. After adjustment for confounders, bone parameters at both the radius and tibia were associated with higher fracture risk. The estimated HRs for fracture did not vary significantly across age quintiles for any HR-pQCT parameter measured at either the radius or tibia. In this large cohort, the homogeneity of the associations between the HR-pQCT measures and fracture risk across age groups persisted for all fractures and for major osteoporotic fractures. The patterns were similar regardless of the HR-pQCT measure, the type of fracture, or the statistical models. The stability of the associations between HR-pQCT measures and fracture over a broad age range shows that bone deficits or low volumetric density remain major determinants of fracture risk regardless of age group. The lower risk for fractures across measures of aBMD in older adults in other studies may be related to factors which interfere with DXA but not with HR-pQCT measures.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae033","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T06:43:04Z","timestamp":1709188984000},"page":"561-570","source":"Crossref","is-referenced-by-count":13,"title":["Fracture risk based on high-resolution peripheral quantitative computed tomography measures does not vary with age in older adults\u2014the bone microarchitecture international consortium prospective cohort study"],"prefix":"10.1093","volume":"39","author":[{"given":"Pawel","family":"Szulc","sequence":"first","affiliation":[{"name":"INSERM UMR1033, University of Lyon , Lyon 69100 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa B","family":"Dufour","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, MA 02131 , United States"},{"name":"Department of Medicine , Beth Israel Deaconess Medical Center, , Boston, MA 02215 , United States"},{"name":"Harvard Medical School , Beth Israel Deaconess Medical Center, , Boston, MA 02215 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-6928","authenticated-orcid":false,"given":"Marian T","family":"Hannan","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, MA 02131 , United States"},{"name":"Department of Medicine , Beth Israel Deaconess Medical Center, , Boston, MA 02215 , United States"},{"name":"Harvard Medical School , Beth Israel Deaconess Medical Center, , Boston, MA 02215 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P","family":"Kiel","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, MA 02131 , United States"},{"name":"Department of Medicine , Beth Israel Deaconess Medical Center, , Boston, MA 02215 , United States"},{"name":"Harvard Medical School , Beth Israel Deaconess Medical Center, , Boston, MA 02215 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"INSERM UMR1033, University of Lyon , Lyon 69100 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sornay-Rendu","sequence":"additional","affiliation":[{"name":"INSERM UMR1033, University of Lyon , Lyon 69100 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Merle","sequence":"additional","affiliation":[{"name":"INSERM UMR1033, University of Lyon , Lyon 69100 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K","family":"Boyd","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary , Calgary AB, T2N 1N4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E","family":"Whittier","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary , Calgary AB, T2N 1N4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Hanley","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary , Calgary AB, T2N 1N4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goltzman","sequence":"additional","affiliation":[{"name":"Departments of Medicine, McGill University and McGill University Health Centre , Montreal, QC, H3A 0G4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Kin On","family":"Wong","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging , University Health Network; and Division of Epidemiology, Dalla Lana School of Public Health, , Toronto, ON, M5R 0A3 , Canada"},{"name":"University of Toronto , University Health Network; and Division of Epidemiology, Dalla Lana School of Public Health, , Toronto, ON, M5R 0A3 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-8518","authenticated-orcid":false,"given":"Eric","family":"Lespessailles","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and PRIMMO, University Hospital of Orl\u00e9ans , Orl\u00e9ans, 45234 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Kogod Center on Aging, Mayo Clinic , Rochester, MN 55902 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases , Geneva University Hospitals and Faculty of Medicine, , Geneva, CH-1211 , Switzerland"},{"name":"University of Geneva , Geneva University Hospitals and Faculty of Medicine, , Geneva, CH-1211 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Biver","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases , Geneva University Hospitals and Faculty of Medicine, , Geneva, CH-1211 , Switzerland"},{"name":"University of Geneva , Geneva University Hospitals and Faculty of Medicine, , Geneva, CH-1211 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L","family":"Bouxsein","sequence":"additional","affiliation":[{"name":"Dept of Orthopedic Surgery, Harvard Medical School, Center for Advanced Orthopaedics Studies, BIDMC , Boston, MA 02215 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Samelson","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, MA 02131 , United States"},{"name":"Department of Medicine , Beth Israel Deaconess Medical Center, , Boston, MA 02215 , United States"},{"name":"Harvard Medical School , Beth Israel Deaconess Medical Center, , Boston, MA 02215 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"issue":"8","key":"2024052412455182100_ref1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"The diagnosis of osteoporosis","volume":"9","author":"Kanis","year":"1994","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2024052412455182100_ref2","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1359\/jbmr.060708","article-title":"BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women","volume":"21","author":"Cummings","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"7","key":"2024052412455182100_ref3","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures","volume":"20","author":"Johnell","year":"2005","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2024052412455182100_ref4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s001980050061","article-title":"How hip and whole-body bone mineral density predict hip fracture in elderly women: the EPIDOS Prospective Study","volume":"8","author":"Schott","year":"1998","journal-title":"Osteoporos Int"},{"issue":"3","key":"2024052412455182100_ref5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s00198-003-1505-1","article-title":"Should age influence the choice of quantitative bone assessment technique in elderly women? 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