{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:34:20Z","timestamp":1791232460394,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Collaborative Research Fund"},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hong Kong Special Administrative Region","award":["C7154-20GF"],"award-info":[{"award-number":["C7154-20GF"]}]},{"name":"Health Bureau, HMRF Research on COVID-19"},{"name":"HKSAR Government","award":["COVID1903011"],"award-info":[{"award-number":["COVID1903011"]}]},{"name":"Laboratory of Data Discovery for Health"},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Population-based epidemiological studies on post-acute phase coronavirus 2019 (COVID-19)-related fractures in older adults are lacking. This study aims to examine the risk of incident major osteoporotic fractures following SARS-CoV-2 infection among individuals aged \u226550, compared to individuals without COVID-19. It was a retrospective, propensity-score matched, population-based cohort study of COVID-19 patients and non-COVID individuals identified from the electronic database of the Hong Kong Hospital Authority from January 2020 to March 2022. The primary outcome was a composite of major osteoporotic fractures (hip, clinical vertebral, and upper limb). COVID-19 patients were 1:1 matched to controls using propensity-score according to age, sex, vaccination status, medical comorbidities and baseline medications. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models. A total of 429\u2009459 COVID-19 patients were included, 1:1 matched to non-COVID individuals. Upon median follow-up of 11\u00a0months, COVID-19 patients had higher risks of major osteoporotic fractures (5.08 vs 3.95 per 1000 persons; HR 1.22 95%CI [1.15\u20131.31]), hip fractures (2.71 vs 1.94; 1.33 [1.22\u20131.46]), clinical vertebral fractures (0.42 vs 0.31; 1.29 [1.03\u20131.62]), and falls (13.83 vs 10.36; 1.28 [1.23\u20131.33]). Subgroup analyses revealed no significant interaction. In acute (within 30\u00a0days) and post-acute phases (beyond 30\u00a0days) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we consistently observed a significant increase in fractures and falls risks. Our study demonstrated increased risk of major osteoporotic fractures after SARS-CoV-2 infection in both acute and post-acute phases in older adults, partly due to increased fall risk. Clinicians should be aware of musculoskeletal health of COVID-19 survivors.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae041","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T16:32:12Z","timestamp":1710001932000},"page":"551-560","source":"Crossref","is-referenced-by-count":13,"title":["Risks of incident major osteoporotic fractures following SARS-CoV-2 infection among older individuals: a population-based cohort study in Hong Kong"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-1126","authenticated-orcid":false,"given":"David T W","family":"Lui","sequence":"first","affiliation":[{"name":"Department of Medicine , School of Clinical Medicine, Li Ka Shing Faculty of Medicine, , Hong Kong SAR , China"},{"name":"The University of Hong Kong , School of Clinical Medicine, Li Ka Shing Faculty of Medicine, , Hong Kong SAR , 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