{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:47:38Z","timestamp":1792799258591,"version":"4.5.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"MGH Endocrine Division","award":["T32DK007028"],"award-info":[{"award-number":["T32DK007028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Vignette<\/jats:title>\n               <jats:p>A 38-yr-old woman with chronic non-surgical hypoparathyroidism, managed elsewhere, presented to our practice with symptomatic hypocalcemia. At the age of 17, she began to suffer from muscle cramps, paresthesia, and ongoing diffuse pain. It took years before she was correctly diagnosed with hypoparathyroidism. Her symptoms were severe enough that she required emergency room visits several times a year. After she was properly diagnosed and started on calcium and calcitriol therapy, she continued to experience frequent episodes of severe hypocalcemia. She saw multiple healthcare providers who each introduced a new regimen. In addition, poor communication led to her discontinuing her medications altogether. As a result, her calcium levels remained consistently low, and she lost confidence in her prospect for better health. At the time of her visit to our clinic, she had discontinued calcitriol, was taking a large amount of oral calcium daily all at once, and had hypocalcemia. We addressed her concerns, and the challenges she faces with adherence to her medication regimen. We provided her with detailed information about the disease and the reasoning behind her treatment plan. Treatment was initiated with calcium carbonate 600\u00a0mg 3 times daily and calcitriol 0.5 mcg once daily. One week after treatment initiation, her test results showed improvement in her albumin-adjusted calcium, phosphorus, and 24-h urine calcium which were all within target range.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae049","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T22:45:52Z","timestamp":1710715552000},"page":"377-381","source":"Crossref","is-referenced-by-count":6,"title":["A delicate balance: the challenges of hypoparathyroidism"],"prefix":"10.1093","volume":"39","author":[{"given":"Garyfallia","family":"Papaioannou","sequence":"first","affiliation":[{"name":"Endocrine Unit , Harvard Medical School, , Boston, MA 02114 , United States"},{"name":"Massachusetts General Hospital , Harvard Medical School, , Boston, MA 02114 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mannstadt","sequence":"additional","affiliation":[{"name":"Endocrine Unit , Harvard Medical School, , Boston, MA 02114 , United 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international workshop","volume":"37","author":"Khan","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"7","key":"2024050213301058500_ref4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.4158\/EP13328.OR","article-title":"Understanding the burden of illness associated with hypoparathyroidism reported among patients in the paradox study","volume":"20","author":"Hadker","year":"2014","journal-title":"Endocr Pract"},{"issue":"11","key":"2024050213301058500_ref5","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1080\/13696998.2019.1624081","article-title":"Clinical burden and healthcare resource utilization among patients with chronic hypoparathyroidism, overall and by adequately vs not adequately controlled disease: a multi-country chart review","volume":"22","author":"Chen","year":"2019","journal-title":"J Med 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