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however, a causal relationship between these 2 common conditions has not been established. By the time clinical cardiovascular disease develops, it is often too late to test whether vascular dysfunction developed before or after the onset of osteoporosis. Therefore, we assessed the association of vascular function, measured by tonometry and brachial hemodynamic testing, with bone density, microarchitecture, and strength, measured by HR-pQCT, in 1391 individuals in the Framingham Heart Study. We hypothesized that decreased vascular function (pulse wave velocity, primary pressure wave, brachial pulse pressure, baseline flow amplitude, and brachial flow velocity) contributes to deficits in bone density, microarchitecture and strength, particularly in cortical bone, which is less protected from excessive blood flow pulsatility than the trabecular compartment. We found that individuals with increased carotid-femoral pulse wave velocity had lower cortical volumetric bone mineral density (tibia: \u22120.21 [\u22120.26, \u22120.15] standardized beta [95% CI], radius: \u22120.20 [\u22120.26, \u22120.15]), lower cortical thickness (tibia: \u22120.09 [\u22120.15, \u22120.04], radius: \u22120.07 [\u22120.12, \u22120.01]) and increased cortical porosity (tibia: 0.20 [0.15, 0.25], radius: 0.21 [0.15, 0.27]). However, these associations did not persist after adjustment for age, sex, height, and weight. These results suggest that vascular dysfunction with aging may not be an etiologic mechanism that contributes to the co-occurrence of osteoporosis and cardiovascular disease in older adults. Further study employing longitudinal measures of HR-pQCT parameters is needed to fully elucidate the link between vascular function and bone health.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae071","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T18:19:00Z","timestamp":1715019540000},"page":"906-917","source":"Crossref","is-referenced-by-count":7,"title":["Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-2597","authenticated-orcid":false,"given":"Ilana M","family":"Usiskin","sequence":"first","affiliation":[{"name":"Division of Rheumatology , Inflammation, and Immunity, , Boston, MA 02115 , United States"},{"name":"Brigham and Women\u2019s Hospital , Inflammation, and Immunity, , Boston, MA 02115 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Cardiovascular Engineering, Inc , Norwood, MA 02062 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L","family":"Bouxsein","sequence":"additional","affiliation":[{"name":"Center for Advanced Orthopedic Studies (CAOS) , Department of Orthopedic Surgery, , Boston, MA 02215 , United States"},{"name":"Beth Israel Deaconess Medical Center , Department of Orthopedic Surgery, , Boston, MA 02215 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Ti","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , School of Public Health, , Boston, MA 02118 , United States"},{"name":"Boston University , School of Public Health, , Boston, MA 02118 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P","family":"Kiel","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, MA 02131 , United States"},{"name":"Department of Medicine, Beth Israel Deaconess Medical Center , Boston, MA 02215 , United States"},{"name":"Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Samelson","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, MA 02131 , United States"},{"name":"Department of Medicine, Beth Israel Deaconess Medical Center , Boston, MA 02215 , United States"},{"name":"Harvard Medical School , Boston, MA 02115 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"issue":"3","key":"2024080610513037200_ref1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of 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