{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:38:40Z","timestamp":1790563120976,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR071986"],"award-info":[{"award-number":["R01AR071986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PO1AG07232"],"award-info":[{"award-number":["PO1AG07232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG037212"],"award-info":[{"award-number":["R01AG037212"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG054023"],"award-info":[{"award-number":["RF1AG054023"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The basis for increased fracture risk in type 2 diabetes (T2DM) is not well understood. In this multi-ethnic, population-based study (n\u2009=\u2009565), we investigated bone microstructure, trabecular plate\/rod morphology, and mineralization in women with T2DM (n\u2009=\u2009175) with and without fracture using a second-generation HRpQCT and individual trabecula segmentation and mineralization (ITS; ITM). Covariate-adjusted aBMD was 3.0%-6.5% higher at all sites (all p&amp;lt;.005) in T2DM vs controls. By HRpQCT, T2DM had higher covariate-adjusted trabecular vBMD (5.3%-6.4%) and number (3.8%-5.1%) and greater cortical area at the radius and tibia. Covariate-adjusted cortical porosity was 10.0% higher at the tibia only in T2DM vs controls, but failure load did not differ. Among women with T2DM, those with adult atraumatic fracture (n\u2009=\u200959) had 5.2%-8.5% lower adjusted aBMD at all sites by DXA compared with those without fracture (n\u2009=\u2009103). By HRpQCT, those with fracture had lower adjusted total vBMD and smaller cortical area (10.2%-16.1%), lower cortical thickness (10.5-15.8%) and lower cortical vBMD associated with 18.1 and 17.2% lower failure load at the radius and tibia, respectively (all p&amp;lt;.05); plate volume and thickness were 5.7% and 4.7% lower, respectively, (p&amp;lt;.05) while rod volume fraction was 12.8% higher in the fracture group at the tibia only. Sodium glucose cotransporter 2 inhibitor users (SGLT2i; n\u2009=\u200919), tended to have lower radial rod tissue mineral density by ITS (p=.06). GLP1 agonist users (n\u2009=\u200919) had trabecular deficits at both sites and higher cortical porosity and larger pores at the distal tibia. In summary, T2DM is associated with increased cortical porosity while those with T2DM and fracture have more marked cortical deficits and fewer trabecular plates associated with lower failure load.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae091","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T06:41:39Z","timestamp":1718088099000},"source":"Crossref","is-referenced-by-count":5,"title":["Fractures in women with type 2 diabetes are associated with marked deficits in cortical parameters and trabecular plates"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-0717","authenticated-orcid":false,"given":"Sanchita","family":"Agarwal","sequence":"first","affiliation":[{"name":"Division of Endocrinology , Department of Medicine, , New York, NY 10032 , United States"},{"name":"Columbia University Irving Medical Center , Department of Medicine, , New York, NY 10032 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Germosen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology , Department of Medicine, , New York, NY 10032 , United States"},{"name":"Columbia University Irving Medical Center , Department of Medicine, , New York, NY 10032 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Rosillo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology , Department of Medicine, , New York, NY 10032 , United States"},{"name":"Columbia University Irving Medical Center , Department of Medicine, , New York, NY 10032 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bucovsky","sequence":"additional","affiliation":[{"name":"Division of Endocrinology , Department of Medicine, , New York, NY 10032 , United States"},{"name":"Columbia University Irving Medical Center , Department of Medicine, , New York, NY 10032 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivelisse","family":"Colon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology , Department of Medicine, , New York, NY 10032 , United States"},{"name":"Columbia University Irving Medical Center , Department of Medicine, , New York, NY 10032 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kil","sequence":"additional","affiliation":[{"name":"Division of Endocrinology , Department of Medicine, , New York, NY 10032 , United States"},{"name":"Columbia University Irving Medical Center , Department of Medicine, , New York, NY 10032 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexi","family":"Wang","sequence":"additional","affiliation":[{"name":"Bone Bioengineering Laboratory , Department of Biomedical Engineering, , New York, NY 10027 , United States"},{"name":"Columbia University , Department of Biomedical Engineering, , New York, NY 10027 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Dinescu","sequence":"additional","affiliation":[{"name":"Bone Bioengineering Laboratory , Department of Biomedical Engineering, , New York, NY 10027 , United States"},{"name":"Columbia University , Department of Biomedical Engineering, , New York, NY 10027 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-7279","authenticated-orcid":false,"given":"Xiang-Dong Edward","family":"Guo","sequence":"additional","affiliation":[{"name":"Bone Bioengineering Laboratory , Department of Biomedical Engineering, , New York, NY 10027 , United States"},{"name":"Columbia University , Department of Biomedical Engineering, , New York, NY 10027 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Walker","sequence":"additional","affiliation":[{"name":"Division of Endocrinology , Department of Medicine, , New York, NY 10032 , United States"},{"name":"Columbia University Irving Medical Center , Department of Medicine, , New York, NY 10032 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"issue":"10397","key":"2024070710252250800_ref1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"402","author":"Ong","year":"2023","journal-title":"Lancet"},{"issue":"5","key":"2024070710252250800_ref2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrendo.2011.233","article-title":"Bone, sweet bone\u2014osteoporotic fractures in diabetes mellitus","volume":"8","author":"Hamann","year":"2012","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"2024070710252250800_ref3","doi-asserted-by":"crossref","first-page":"F188","DOI":"10.1152\/ajprenal.00518.2013","article-title":"Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia","volume":"306","author":"Rieg","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"issue":"10","key":"2024070710252250800_ref4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41574-020-0392-2","article-title":"Sodium\u2013glucose cotransporter type 2 inhibitors for the treatment of type 2 diabetes mellitus","volume":"16","author":"Scheen","year":"2020","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"2024070710252250800_ref5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2337\/dc19-0925","article-title":"Vertebral fractures in individuals with type 2 diabetes: more than skeletal complications alone","volume":"43","author":"Koromani","year":"2020","journal-title":"Diabetes Care"},{"issue":"4","key":"2024070710252250800_ref6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00198-006-0253-4","article-title":"Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes\u2014a meta-analysis","volume":"18","author":"Vestergaard","year":"2007","journal-title":"Osteoporos Int"},{"issue":"21","key":"2024070710252250800_ref7","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1001\/jama.2011.715","article-title":"Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes","volume":"305","author":"Schwartz","year":"2011","journal-title":"JAMA"},{"issue":"11","key":"2024070710252250800_ref8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41574-021-00555-5","article-title":"Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus","volume":"17","author":"Khosla","year":"2021","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"2024070710252250800_ref9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.4239\/wjd.v6.i5.673","article-title":"Update on type 2 diabetes-related osteoporosis","volume":"6","author":"Wongdee","year":"2015","journal-title":"World J Diabetes"},{"issue":"11","key":"2024070710252250800_ref10","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1210\/jc.2010-0226","article-title":"High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus","volume":"95","author":"Burghardt","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024070710252250800_ref11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.1763","article-title":"Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures","volume":"28","author":"Patsch","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024070710252250800_ref12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00198-014-2927-7","article-title":"Defects in cortical microarchitecture among African-American women with type 2 diabetes","volume":"26","author":"Yu","year":"2015","journal-title":"Osteoporos Int"},{"issue":"5","key":"2024070710252250800_ref13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00223-015-0100-8","article-title":"Bone microarchitecture in men and women with diabetes: the importance of cortical porosity","volume":"98","author":"Paccou","year":"2016","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"2024070710252250800_ref14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1530\/EJE-15-0860","article-title":"Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease","volume":"174","author":"Shanbhogue","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"2024070710252250800_ref15","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1007\/s00198-018-4678-3","article-title":"The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomography\u2014the Maastricht study","volume":"29","author":"De Waard","year":"2018","journal-title":"Osteoporos Int"},{"issue":"1","key":"2024070710252250800_ref16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/jbmr.3240","article-title":"Diabetes and deficits in cortical bone density, microarchitecture, and bone size: Framingham HR-pQCT study","volume":"33","author":"Samelson","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024070710252250800_ref17","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00198-011-1595-0","article-title":"Bone structure and turnover in type 2 diabetes mellitus","volume":"23","author":"Shu","year":"2011","journal-title":"Osteoporos Int"},{"issue":"4","key":"2024070710252250800_ref18","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jbmr.2106","article-title":"In vivo assessment of bone quality in postmenopausal women with type 2 diabetes","volume":"29","author":"Farr","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2024070710252250800_ref19","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1210\/jc.2016-1437","article-title":"Advanced glycation endproducts and bone material strength in type 2 diabetes","volume":"101","author":"Furst","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024070710252250800_ref20","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/jbmr.3057","article-title":"Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: a population-based study","volume":"32","author":"Nilsson","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024070710252250800_ref21","doi-asserted-by":"crossref","first-page":"e0174664","DOI":"10.1371\/journal.pone.0174664","article-title":"Similarities in trabecular hypertrophy with site-specific differences in cortical morphology between men and women with type 2 diabetes mellitus","volume":"12","author":"Patsch","year":"2017","journal-title":"PLoS One"},{"issue":"9","key":"2024070710252250800_ref22","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/jbmr.3465","article-title":"Robust trabecular microstructure in type 2 diabetes revealed by individual trabecula segmentation analysis of HR-pQCT images","volume":"33","author":"Starr","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"9","key":"2024070710252250800_ref23","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/jbmr.2498","article-title":"Distinct tissue mineral density in plate-and rod-like trabeculae of human trabecular bone","volume":"30","author":"Wang","year":"2015","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2024070710252250800_ref24","doi-asserted-by":"crossref","first-page":"e1072","DOI":"10.1002\/jbm4.10725","article-title":"Skeletal microstructure in Caribbean Hispanic women","volume":"7","author":"Agarwal","year":"2023","journal-title":"JBMR Plus"},{"issue":"12","key":"2024070710252250800_ref25","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/alz.12154","article-title":"Dietary fatty acids and risk of Alzheimer's disease and related dementias: observations from the Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP)","volume":"16","author":"Gustafson","year":"2020","journal-title":"Alzheimers Dement"},{"issue":"4","key":"2024070710252250800_ref26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bone.2007.07.007","article-title":"Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis","volume":"41","author":"Buie","year":"2007","journal-title":"Bone"},{"issue":"6","key":"2024070710252250800_ref27","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S8756-3282(02)00736-6","article-title":"Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images","volume":"30","author":"Pistoia","year":"2002","journal-title":"Bone"},{"issue":"2","key":"2024070710252250800_ref28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1359\/jbmr.071009","article-title":"Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone","volume":"23","author":"Liu","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2024070710252250800_ref29","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0031-3203(97)00016-2","article-title":"A new shape preserving parallel thinning algorithm for 3D digital images","volume":"30","author":"Saha","year":"1997","journal-title":"Pattern Recogn"},{"issue":"3","key":"2024070710252250800_ref30","doi-asserted-by":"crossref","DOI":"10.1093\/jbmrpl\/ziae007","article-title":"Individual trabecula segmentation validation in first- and second-generation high-resolution peripheral computed tomography compared to micro-computed tomography in the distal radius and tibia","volume":"8","author":"Dinescu","year":"2024","journal-title":"JBMR Plus"},{"key":"2024070710252250800_ref31","volume-title":"Individual Trabecular Mineralization by HR-pQCT Images","author":"Wang","year":"2021"},{"issue":"3","key":"2024070710252250800_ref32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00008486-199406000-00013","article-title":"A dietary calcium rapid assessment method (RAM)","volume":"9","author":"Hertzler","year":"1994","journal-title":"Top Clin Nutr"},{"issue":"10","key":"2024070710252250800_ref33","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1007\/s00198-016-3621-8","article-title":"In vivo assessment of bone structure and estimated bone strength by first- and second-generation HR-pQCT","volume":"27","author":"Agarwal","year":"2016","journal-title":"Osteoporos Int"},{"issue":"1","key":"2024070710252250800_ref34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S2213-8587(18)30308-5","article-title":"Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study","volume":"7","author":"Samelson","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2024070710252250800_ref35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1210\/jc.2015-3167","article-title":"Effects of canagliflozin on fracture risk in patients with type 2 diabetes mellitus","volume":"101","author":"Watts","year":"2016","journal-title":"J Clin Endocrinol"},{"issue":"7","key":"2024070710252250800_ref36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N Engl J Med"},{"issue":"10","key":"2024070710252250800_ref37","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1007\/s00125-019-4955-5","article-title":"Canagliflozin and fracture risk in individuals with type 2 diabetes: results from the CANVAS program","volume":"62","author":"Zhou","year":"2019","journal-title":"Diabetologia"},{"issue":"8","key":"2024070710252250800_ref38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41581-018-0028-0","article-title":"Adverse effects of SGLT2 inhibitors on bone health","volume":"14","author":"Blau","year":"2018","journal-title":"Nat Rev Nephrol"},{"issue":"12","key":"2024070710252250800_ref39","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00198-023-06908-2","article-title":"Effect of SGLT2 inhibitors on fractures, BMD, and bone metabolism markers in patients with type 2 diabetes mellitus: a systematic review and meta-analysis","volume":"34","author":"Wang","year":"2023","journal-title":"Osteoporos Int"},{"issue":"1","key":"2024070710252250800_ref40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1210\/jc.2015-1860","article-title":"Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin","volume":"101","author":"Bilezikian","year":"2016","journal-title":"J Clin Endocrinol"},{"key":"2024070710252250800_ref41","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01517","article-title":"Effect of sodium-glucose co-transporter 2 inhibitors on bone metabolism and fracture risk","volume":"9","author":"Ye","year":"2019","journal-title":"Front Pharmacol"},{"issue":"4","key":"2024070710252250800_ref42","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1463-1326.2010.01355.x","article-title":"Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes","volume":"13","author":"Bunck","year":"2011","journal-title":"Diabetes Obes Metab"},{"issue":"4","key":"2024070710252250800_ref43","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4158\/EP15758.OR","article-title":"Comparison of the long-term effects of liraglutide and glimepiride monotherapy on bone mineral density in patients with type 2 diabetes","volume":"22","author":"Gilbert","year":"2016","journal-title":"Endocr Pract"},{"issue":"1","key":"2024070710252250800_ref44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12020-014-0361-4","article-title":"Risk of bone fractures associated with glucagon-like peptide-1 receptor agonists\u2019 treatment: a meta-analysis of randomized controlled trials","volume":"48","author":"Su","year":"2015","journal-title":"Endocrine"},{"issue":"3","key":"2024070710252250800_ref45","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/1753-0407.12102","article-title":"Use of glucagon-like peptide-1 receptor agonists and bone fractures: a meta-analysis of randomized clinical trials","volume":"6","author":"Mabilleau","year":"2014","journal-title":"J Diabetes"},{"issue":"2","key":"2024070710252250800_ref46","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1210\/en.2007-1292","article-title":"The murine glucagon-like peptide-1 receptor is essential for control of bone resorption","volume":"149","author":"Yamada","year":"2008","journal-title":"Endocrinology"},{"issue":"1","key":"2024070710252250800_ref47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/JOE-13-0146","article-title":"Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptor","volume":"219","author":"Mabilleau","year":"2013","journal-title":"J Endocrinol"},{"issue":"2","key":"2024070710252250800_ref48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1530\/JOE-11-0015","article-title":"Glp-1 and exendin-4 can reverse hyperlipidic-related osteopenia","volume":"209","author":"Nuche-Berenguer","year":"2011","journal-title":"J Endocrinol"},{"issue":"4","key":"2024070710252250800_ref49","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/1753-0407.12282","article-title":"Liraglutide, the glucagon-like peptide-1 receptor agonist, has anabolic bone effects in diabetic Goto-Kakizaki rats","volume":"7","author":"Sun","year":"2015","journal-title":"J Diabetes"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbmr\/advance-article-pdf\/doi\/10.1093\/jbmr\/zjae091\/58463517\/zjae091.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/advance-article-pdf\/doi\/10.1093\/jbmr\/zjae091\/58463517\/zjae091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T10:25:50Z","timestamp":1720347950000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/advance-article\/doi\/10.1093\/jbmr\/zjae091\/7691180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":49,"URL":"https:\/\/doi.org\/10.1093\/jbmr\/zjae091","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]},"article-number":"zjae091"}}