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Friedman Chair in Women's Genetic Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bruck syndrome is an autosomal recessive form of osteogenesis imperfecta caused by biallelic variants in PLOD2 or FKBP10 and is characterized by joint contractures, bone fragility, short stature, and scoliosis. PLOD2 encodes LH2, which hydroxylates type I collagen telopeptide lysines, a critical step for collagen crosslinking. The Plod2 global knockout mouse model is limited by early embryonic lethality, and thus, the role of PLOD2 in skeletogenesis is not well understood. We generated a novel Plod2 mouse line modeling a variant identified in two unrelated individuals with Bruck syndrome: PLOD2 c.1559dupC, predicting a frameshift and loss of the long isoform LH2b. In the mouse, the duplication led to loss of LH2b mRNA as well as significantly reduced total LH2 protein. This model, Plod2fs\/fs, survived up to E18.5 although in non-Mendelian genotype frequencies. The homozygous frameshift model recapitulated the joint contractures seen in Bruck syndrome and had indications of absent type I collagen telopeptide lysine hydroxylation in bone. Genetically labeling tendons with Scleraxis-GFP in Plod2fs\/fs mice revealed the loss of extensor tendons in the forelimb by E18.5, and developmental studies showed extensor tendons developed through E14.5 but were absent starting at E16.5. Second harmonic generation showed abnormal tendon type I collagen fiber organization, suggesting structurally abnormal tendons. Characterization of the skeleton by \u03bcCT and Raman spectroscopy showed normal bone mineralization levels. This work highlights the importance of properly crosslinked type I collagen in tendon and bone, providing a promising new mouse model to further our understanding of Bruck syndrome.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae124","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T08:41:48Z","timestamp":1722501708000},"page":"1240-1252","source":"Crossref","is-referenced-by-count":7,"title":["Loss of the long form of <i>Plod2<\/i> phenocopies contractures of Bruck syndrome\u2014osteogenesis imperfecta"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2355-0630","authenticated-orcid":false,"given":"Alexander","family":"Kot","sequence":"first","affiliation":[{"name":"Orthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles , Los Angeles, CA 90095, United States"},{"name":"Human Genetics, David Geffen School of Medicine at University of California at Los Angeles , Los Angeles, CA 90095, 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Medicine, University of Washington , Seattle, WA 98195, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaryAnn","family":"Weis","sequence":"additional","affiliation":[{"name":"Orthopaedics and Sports Medicine, University of Washington , Seattle, WA 98195, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Marks","sequence":"additional","affiliation":[{"name":"California NanoSystems Institute, University of California at Los Angeles , Los Angeles, CA 90095, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering, University of California at Los Angeles , Los Angeles, CA 90095, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Eyre","sequence":"additional","affiliation":[{"name":"Orthopaedics and Sports Medicine, University of 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