{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:33:56Z","timestamp":1793572436319,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01-AG-1-2100"],"award-info":[{"award-number":["N01-AG-1-2100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Icelandic Parliament"},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR064140"],"award-info":[{"award-number":["R01AR064140"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR077924"],"award-info":[{"award-number":["R01AR077924"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR068456"],"award-info":[{"award-number":["R01AR068456"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR080423"],"award-info":[{"award-number":["R01AR080423"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A better understanding of how age-related bone loss affects the fracture-prone regions of the proximal femur could lead to more informed fracture-prevention strategies. Therefore, the aim of this work was to assess the spatio-temporal distribution of bone deterioration in older men and women with aging. A subset of 305 men (74.87\u2009\u00b1\u20094.76\u00a0years; mean\u2009\u00b1\u2009SD) and 371 age-matched women (74.84\u2009\u00b1\u20094.71\u00a0years) with no history of fracture was randomly selected from the Age, Gene\/Environment Susceptibility-Reykjavik study. Quantitative computed tomography (QCT) scans of the left proximal femur obtained at baseline and at 5.2\u2009\u00b1\u20090.4\u00a0years follow-up were processed to assess local changes in volumetric bone mineral density (vBMD), cortical bone thickness (Ct.Th), and internal bone structure using voxel-based morphometry (VBM), surface-based statistical parametric mapping (surf-SPM), and tensor-based morphometry (TBM). Local parametric changes within each sex and sex differences in these changes were statistically assessed using linear mixed effects models allowing for baseline and time-varying covariates, yielding Student\u2019s t-test and p-value statistical maps of the proximal femur. The statistical maps indicated regions with significant parametric changes in each sex and with significant different parametric changes between older men and older women with aging. Older women manifested significantly larger losses in vBMD, (Ct.Th), and structure than older men, and they did so in regions where deficiency in these parameters has been associated with incident hip fracture. Using longitudinal QCT scans of the proximal femur and Computational Anatomy, we provided new insights into the higher fracture rates of the proximal femur in older women compared with men of similar age providing new information on the pathophysiology of osteoporosis.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae132","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T14:23:54Z","timestamp":1723818234000},"page":"1443-1453","source":"Crossref","is-referenced-by-count":7,"title":["Male\u2013female spatio-temporal differences of age-related bone changes show faster bone deterioration in older women at femoral regions associated with incident hip fracture"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-7182","authenticated-orcid":false,"given":"Julio","family":"Carballido-Gamio","sequence":"first","affiliation":[{"name":"Department of Radiology , School of Medicine, , Aurora, CO 80045,","place":["United 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201, K\u00f3pavogur,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Jensen","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Unit , Department of Medicine, , Stanford, CA 94304,","place":["United States"]},{"name":"Stanford University , Department of Medicine, , Stanford, CA 94304,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association Research Institute , Holtasm\u00e1ri 1, 201, K\u00f3pavogur,","place":["Iceland"]},{"name":"University of Iceland , S\u00e6mundargata 2, 102, Reykjavik,","place":["Iceland"]},{"name":"Landspitalinn University Hospital , Skaftahl\u00ed\u00f0 24 skrifstofur, 105, Reykjavik,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Aspelund","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association Research Institute , Holtasm\u00e1ri 1, 201, K\u00f3pavogur,","place":["Iceland"]},{"name":"Centre of Public Health Sciences, University of Iceland , Sturlugata 8, 102, Reykjavik,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association Research Institute , Holtasm\u00e1ri 1, 201, K\u00f3pavogur,","place":["Iceland"]},{"name":"University of Iceland , S\u00e6mundargata 2, 102, Reykjavik,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California , San Francisco, CA 94143,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B","family":"Harris","sequence":"additional","affiliation":[{"name":"Intramural Research Program , Laboratory of Epidemiology and Population Sciences, , Gateway Building, Suite 2N300, Bethesda, MD 20892,","place":["United States"]},{"name":"National Institute on Aging , Laboratory of Epidemiology and Population Sciences, , Gateway Building, Suite 2N300, Bethesda, MD 20892,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"2024092612154349100_ref1","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/S0140-6736(02)08761-5","article-title":"Diagnosis of osteoporosis and assessment of fracture 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