{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:32:44Z","timestamp":1793748764137,"version":"4.6.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","award":["50564"],"award-info":[{"award-number":["50564"]}],"id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Abondement ANVAR","award":["E1482.042"],"award-info":[{"award-number":["E1482.042"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-BLAN-1137"],"award-info":[{"award-number":["ANR-10-BLAN-1137"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-07-PHYSIO-023"],"award-info":[{"award-number":["ANR-07-PHYSIO-023"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG065299"],"award-info":[{"award-number":["R01AG065299"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Heart, Lung, and Blood Institute Framingham Heart Study","award":["HHSN268201500001I"],"award-info":[{"award-number":["HHSN268201500001I"]}]},{"name":"National Heart, Lung, and Blood Institute Framingham Heart Study","award":["N01-HC-25195"],"award-info":[{"award-number":["N01-HC-25195"]}]},{"name":"National Institute of Arthritis Musculoskeletal and Skin Diseases of the National Institutes of Health","award":["AR027065"],"award-info":[{"award-number":["AR027065"]}]},{"name":"National Institute of Arthritis Musculoskeletal and Skin Diseases of the National Institutes of Health","award":["R01AR061445"],"award-info":[{"award-number":["R01AR061445"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Identifying individuals at risk for short-term fracture is essential to offer prompt beneficial treatment, especially since many fractures occur in those without osteoporosis by DXA-aBMD. We evaluated whether deficits in bone microarchitecture and density predict short-term fracture risk independent of the clinical predictors, DXA-BMD and FRAX. We combined data from eight cohorts to conduct a prospective study of bone microarchitecture at the distal radius and tibia (by HR-pQCT) and 2-year incidence of fracture (non-traumatic and traumatic) in 7327 individuals (4824 women, 2503 men, mean 69\u2009\u00b1\u20099\u00a0years). We estimated sex-specific hazard ratios (HR) for associations between bone measures and 2-year fracture incidence, adjusted for age, cohort, height, and weight, and then additionally adjusted for FN aBMD or FRAX for major osteoporotic fracture. Only 7% of study participants had FN T-score\u2009\u2264\u2009\u22122.5, whereas 53% had T-scores between \u22121.0 and \u22122.5 and 37% had T-scores \u2265\u22121.0. Two-year cumulative fracture incidence was 4% (296\/7327). Each SD decrease in radius cortical bone measures increased fracture risk by 38%-76% for women and men. After additional adjustment for FN-aBMD, risks remained increased by 28%-61%. Radius trabecular measures were also associated with 2-year fracture risk independently of FN-aBMD in women (HRs range: 1.21 per SD for trabecular separation to 1.55 for total vBMD). Decreased failure load (FL) was associated with increased fracture risk in both women and men (FN-aBMD ranges of adjusted HR\u2009=\u20091.47-2.42). Tibia measurement results were similar to radius results. Findings were also similar when models were adjusted for FRAX. In older adults, FL and HR-pQCT measures of cortical and trabecular bone microarchitecture and density with strong associations to short-term fractures improved fracture prediction beyond aBMD and FRAX. Thus, HR-pQCT may be a useful adjunct to traditional assessment of short-term fracture risk in older adults, including those with T-scores above the osteoporosis range.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae143","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T21:29:16Z","timestamp":1725571756000},"page":"1574-1583","source":"Crossref","is-referenced-by-count":24,"title":["Short-term risk of fracture is increased by deficits in cortical and trabecular bone microarchitecture independent of DXA BMD and FRAX: Bone Microarchitecture International Consortium (BoMIC) prospective cohorts"],"prefix":"10.1093","volume":"39","author":[{"given":"Marine","family":"Sarfati","sequence":"first","affiliation":[{"name":"INSERM UMR1033, Universit\u00e9 de Lyon, H\u00f4pital Edouard Herriot , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"INSERM UMR1033, Universit\u00e9 de Lyon, H\u00f4pital Edouard Herriot , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa B","family":"Dufour","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, and the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sornay-Rendu","sequence":"additional","affiliation":[{"name":"INSERM UMR1033, Universit\u00e9 de Lyon, H\u00f4pital Edouard Herriot , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Merle","sequence":"additional","affiliation":[{"name":"INSERM UMR1033, Universit\u00e9 de Lyon, H\u00f4pital Edouard Herriot , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-5997","authenticated-orcid":false,"given":"Steven K","family":"Boyd","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary , Calgary AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-551X","authenticated-orcid":false,"given":"Danielle E","family":"Whittier","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary , Calgary AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-3742","authenticated-orcid":false,"given":"David A","family":"Hanley","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary , Calgary AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goltzman","sequence":"additional","affiliation":[{"name":"Departments of Medicine, McGill University and McGill University Health Centre , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Szulc","sequence":"additional","affiliation":[{"name":"INSERM UMR1033, Universit\u00e9 de Lyon, H\u00f4pital Edouard Herriot , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8540-8854","authenticated-orcid":false,"given":"Andy Kin On","family":"Wong","sequence":"additional","affiliation":[{"name":"Toronto General Hospital and University Health Network and Department of Epidemiology , Dalla Lana School of Public Health, , Toronto, ON,","place":["Canada"]},{"name":"University of Toronto , Dalla Lana School of Public Health, , Toronto, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-8518","authenticated-orcid":false,"given":"Eric","family":"Lespessailles","sequence":"additional","affiliation":[{"name":"Regional University Hospital of Orl\u00e9ans, PRIMMO , Orl\u00e9ans,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Kogod Center on Aging, Mayo Clinic , Rochester, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Biver","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre , Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, , Gothenburg,","place":["Sweden"]},{"name":"University of Gothenburg , Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-1431","authenticated-orcid":false,"given":"Mattias","family":"Lorentzon","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre , Department of Internal Medicine and Clinical Nutrition, , Gothenburg,","place":["Sweden"]},{"name":"Institute of Medicine, University of Gothenburg , Department of Internal Medicine and Clinical Nutrition, , Gothenburg,","place":["Sweden"]},{"name":"Region V\u00e4stra G\u00f6taland , Department of Geriatric Medicine, , M\u00f6lndal,","place":["Sweden"]},{"name":"Sahlgrenska University Hospital , Department of Geriatric Medicine, , M\u00f6lndal,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre , Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, , Gothenburg,","place":["Sweden"]},{"name":"University of Gothenburg , Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nethander","sequence":"additional","affiliation":[{"name":"Sahlgrenska Osteoporosis Centre , Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, , Gothenburg,","place":["Sweden"]},{"name":"University of Gothenburg , Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, , Gothenburg,","place":["Sweden"]},{"name":"Bioinformatics and Data Center , Sahlgrenska Academy, , Gothenburg,","place":["Sweden"]},{"name":"University of Gothenburg , Sahlgrenska Academy, , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Samelson","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, and the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8474-0310","authenticated-orcid":false,"given":"Douglas P","family":"Kiel","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, and the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-6928","authenticated-orcid":false,"given":"Marian T","family":"Hannan","sequence":"additional","affiliation":[{"name":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, and the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L","family":"Bouxsein","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery , Harvard Medical School, , Boston, MA,","place":["United States"]},{"name":"Center for Advanced Orthopedic Studies, BIDMC , Harvard Medical School, , Boston, MA,","place":["United 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