{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:24:17Z","timestamp":1793381057776,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypophosphatasia (HPP) is a rare disorder of the bone metabolism, characterized by genetically determined low alkaline phosphatase (ALP) activity. Low ALP may also be observed in some common causes of bone fragility, such as in osteoporosis treated with antiresorptive drugs. This study aimed to verify whether differences in bone turnover markers (BTMs) could help differentiate adult patients with HPP from those with osteoporosis undergoing antiresorptive treatment. In this multicenter study, we enrolled 23 adult patients with a diagnosis of HPP and compared them with 46 osteoporotic subjects previously treated with zoledronic acid or denosumab. BTMs such as CTX, N-terminal propeptide of type I procollagen (P1NP), total ALP, and bone ALP (bALP) were measured, and ratios between BTMs were also calculated. Considering that the control group included only females, in the primary analysis we compared their characteristics with that of the 16 female patients with HPP. Both individual BTMs (CTX and P1NP) and 4 BTM ratios (ALP\/P1NP, bALP\/P1NP, ALP\/CTX, and bALP\/CTX) showed satisfactory discriminatory power, outperforming ALP alone. P1NP, in particular, had an area under the curve (AUC) of 0.962 with a cut-off of 32\u00a0\u03bcg\/L, while as for the BTMs ratios, the ALP\/P1NP ratio had an AUC of 0.964 with a cut-off of 1.114. Similar results were confirmed when including male HPP patients, when adjusting for age and sex, and finally when performing a sensitivity analysis only in patients with ALP less than or equal to 32\u00a0U\/L (ie, the median of the distribution of the entire population). In cases of low ALP and bone fragility, BTM and their ratios could help distinguish HPP patients from osteoporotic individuals treated with antiresorptive drugs, aiding in accurate diagnosis and reducing the risk of inappropriate treatment.<\/jats:p>","DOI":"10.1093\/jbmr\/zjae177","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:17:28Z","timestamp":1730333848000},"page":"79-86","source":"Crossref","is-referenced-by-count":12,"title":["Possible role of bone turnover markers in the diagnosis of adult hypophosphatasia"],"prefix":"10.1093","volume":"40","author":[{"given":"Francesco","family":"Bertoldo","sequence":"first","affiliation":[{"name":"Bone Metabolism and Osteoncology Unit, University of Verona , 37129 Verona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Tripepi","sequence":"additional","affiliation":[{"name":"National Research Council (CNR), Institute of Clinical Physiology (IFC), Clinical Epidemiology of Renal Diseases and Hypertension, Ospedali Riuniti , 89124 Reggio Calabria ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Zaninotto","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Unit , Department of Medicine, , 35128 Padova ,","place":["Italy"]},{"name":"University of Padua , Department of Medicine, , 35128 Padova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Plebani","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Unit , Department of Medicine, , 35128 Padova ,","place":["Italy"]},{"name":"University of Padua , Department of Medicine, , 35128 Padova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Scillitani","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetology, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS , 71013 San Giovanni Rotondo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Varenna","sequence":"additional","affiliation":[{"name":"Bone Diseases Unit , Department of Rheumatology and Medical Sciences, , 20122 Milan ,","place":["Italy"]},{"name":"ASST-G. Pini-CTO , Department of Rheumatology and Medical Sciences, , 20122 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Crotti","sequence":"additional","affiliation":[{"name":"Bone Diseases Unit , Department of Rheumatology and Medical Sciences, , 20122 Milan ,","place":["Italy"]},{"name":"ASST-G. Pini-CTO , Department of Rheumatology and Medical Sciences, , 20122 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-1202","authenticated-orcid":false,"given":"Cristiana","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Department of Clinical , Internal, Anaesthesiology, and Cardiovascular Sciences, , 00161 Rome ,","place":["Italy"]},{"name":"Sapienza University of Rome , Internal, Anaesthesiology, and Cardiovascular Sciences, , 00161 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Pepe","sequence":"additional","affiliation":[{"name":"Department of Clinical , Internal, Anaesthesiology, and Cardiovascular Sciences, , 00161 Rome ,","place":["Italy"]},{"name":"Sapienza University of Rome , Internal, Anaesthesiology, and Cardiovascular Sciences, , 00161 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Minisola","sequence":"additional","affiliation":[{"name":"Department of Clinical , Internal, Anaesthesiology, and Cardiovascular Sciences, , 00161 Rome ,","place":["Italy"]},{"name":"Sapienza University of Rome , Internal, Anaesthesiology, and Cardiovascular Sciences, , 00161 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetology, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS , 71013 San Giovanni Rotondo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS , 71013 San Giovanni Rotondo 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,","place":["Italy"]},{"name":"University of Padua, European Reference Network on Rare Bone Diseases (ERN BOND) , Department of Medicine, , 35128 Padova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fusaro","sequence":"additional","affiliation":[{"name":"National Research Council (CNR), Institute of Clinical Physiology (IFC) , 56124 Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Rossini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit , Department of Medicine, , 37129 Verona ,","place":["Italy"]},{"name":"University of Verona , Department of Medicine, , 37129 Verona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[{"name":"FIRMO Foundation (Italian Foundation for the Research on Bone Diseases) , 50129 Florence 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