{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:36Z","timestamp":1787009076803,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR056837"],"award-info":[{"award-number":["AR056837"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR072713"],"award-info":[{"award-number":["AR072713"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pediatric Orthopaedic Society of North America (POSNA) Angela S.M. Kuo Memorial Award","award":["823038"],"award-info":[{"award-number":["823038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Growth-plate (GP) injures in limbs and other sites can impair GP function and cause deceleration of bone growth, leading to progressive bone lengthening imbalance, deformities and\/or physical discomfort, decreased motion and pain. At present, surgical interventions are the only means available to correct these conditions by suppressing the GP activity in the unaffected limb and\/or other bones in the ipsilateral region. Here, we aimed to develop a pharmacologic treatment of GP growth imbalance that involves local application of nanoparticles (NP)-based controlled release of a selective retinoic acid nuclear receptor gamma (RAR\u03b3) agonist drug. When RAR\u03b3 agonist-loaded NP were implanted near the medial and lateral sides of proximal tibial growth plate in juvenile C57BL\/6J mice, the GP underwent involution and closure. Overall tibia length was shortened compared to the contralateral element implanted with drug-free control NP. Importantly, when the RAR\u03b3 agonist NP were implanted on the lateral side only, the adjacent epiphysis tilted toward the lateral side, leading to apical angulation of the tibia. In contrast to the local selectivity of these responses, systemic administration of RAR\u03b3 agonists led to GP closure at many sites, inhibiting skeletal growth over time. Agonists for RAR\u03b1 and RAR\u03b2 elicited no obvious responses over parallel regimens. Our findings provide novel evidence that RAR\u03b3 agonist-loaded NP can control activity, function and directionality of a targeted GP, offering a potential and clinically-relevant alternative or supplementation to surgical correction of limb length discrepancy and angular deformities.<\/jats:p>","DOI":"10.1093\/jbmr\/zjaf018","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T23:14:15Z","timestamp":1737846855000},"page":"535-547","source":"Crossref","is-referenced-by-count":2,"title":["Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice"],"prefix":"10.1093","volume":"40","author":[{"given":"Masatake","family":"Matsuoka","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, University of Maryland School of Medicine , Baltimore, MD ,","place":["United States"]},{"name":"Department of Orthopaedic Surgery, Graduate School of Medicine, Hokkaido University , 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