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Here we use single-cell RNA sequencing and lineage tracing to show that all these osteoblast precursors, even postnatally, derives from Sox9-expressing progenitors. We also characterize a distinct group of chondrocytes located between the perichondrium and the columns of growth plate chondrocytes that contribute to the osteoblast lineage.<\/jats:p>","DOI":"10.1093\/jbmr\/zjaf043","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T22:09:27Z","timestamp":1743286167000},"page":"799-812","source":"Crossref","is-referenced-by-count":7,"title":["Single cell RNA sequencing shows that cells expressing Sox9 postnatally populate most skeletal lineages in mouse bone"],"prefix":"10.1093","volume":"40","author":[{"given":"Neal P","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital , Boston, MA 02114 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Janton","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Massachusetts General Hospital 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